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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PJA2 (from a repository: Thu Dec 1 20:18:06 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins8 (30.77 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)84 (25.85 %)
The number (and %) of affected PPIs26 (30.95 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.231
Assortativity coefficient-0.4217
The network average Clustering coefficient0.686
The number (and %) of a zero Clustering coefficients2 (7.69 %)
The number (and %) of a zero Betweenness Centrality13 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PJA2 All fusions
: CN307923;
Proteins found in more fusions PJA2 (see 1 fusions); PRKAR1A (see 2 fusions); AP2M1 (see 3 fusions); UBE2D2 (see 2 fusions); UBE2N (see 1 fusions); FAF1 (see 2 fusions); CUL3 (see 1 fusions); UBE2L6 (see 2 fusions); MAGED1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PJA2parental protein260.143386.967zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
2 AP2M1protein found in more fusions40.6670.400Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
3 CEP192interactor21.0000Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like
MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
4 CUL3protein found in more fusions140.33344.233Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
5 ELAVL1oncoprotein110.31129.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
6 FAF1protein found in more fusions51.0000UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
7 FAF2interactor90.5718.900DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
8 FBXL17interactor21.0000TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
9 KIAA0753interactor21.0000MNR (PF15718, IPR031447): Protein moonraker
10 MAGED1protein found in more fusions80.47610.333MAGE (PF01454, IPR002190): MAGE family
11 MAGED2interactor40.6671.400CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
MAGE (PF01454, IPR002190): MAGE family
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
12 PRKAR1Asuppressor50.8330.400RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
13 PRKAR2Ainteractor31.0000RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
14 UBE2D1interactor70.6673.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
15 UBE2D2oncoprotein51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
16 UBE2D3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 UBE2D4interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2J1interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
19 UBE2L6protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 UBE2Nprotein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
21 UBE2Winteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
22 UBXN1interactor80.6195.667Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
23 UBXN7interactor70.7143.400UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
24 UNKinteractor40.5002.400MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
25 USP46interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
26 XPO1interactor80.32117.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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