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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIP4K2B (from a repository: Sun Dec 4 05:20:53 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins3 (15.79 %)
The number (and %) of the tumor suppressors3 (15.79 %)
Total number of binary PPIs (saturation %)34 (19.88 %)
The number (and %) of affected PPIs19 (55.88 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.737
Assortativity coefficient-0.4992
The network average Clustering coefficient0.336
The number (and %) of a zero Clustering coefficients10 (52.63 %)
The number (and %) of a zero Betweenness Centrality13 (68.42 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PIP4K2B All fusions
: BF991438; AA247774; BF849647;
Proteins found in more fusions PRPF8 (see 3 fusions); PIP4K2B (see 3 fusions); TNFRSF1A (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIP4K2Bparental protein190.052283.333PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
2 ARL6IP4interactor40.6670.667SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
3 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
4 CLK1interactor200PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
5 CSNK2A2interactor40.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
6 DDX23interactor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3698 (PF12479, IPR022167): Protein of unknown function (DUF3698)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
7 EAF1suppressor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
8 EPB41L3suppressor40.6671.6674_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
9 HMBOX1interactor200DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
DUF494 (PF04361, IPR007456): Protein of unknown function (DUF494)
HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 LIN7Ainteractor100DUF932 (PF06067, IPR026325): Domain of unknown function (DUF932)
L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
11 MED18interactor21.0000Med18 (PF09637, IPR019095): Med18 protein
12 MED4interactor40.6672.000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
13 MYL9interactor100UPF0154 (PF03672, IPR005359): Uncharacterised protein family (UPF0154)
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14 PRPF8oncoprotein31.0000PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
15 SKP1oncoprotein100Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
16 SPOPsuppressor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
17 TNFRSF1Aoncoprotein200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
18 UBQLN4interactor200CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
19 ZRANB2interactor30.6670.667RRN3 (PF05327, IPR007991): RNA polymerase I specific transcription initiation factor RRN3
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARL6IP4interactorSR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated proteinBF849647
2 CSNK2A2interactorPkinase (PF00069, IPR000719): Protein kinase domainBF849647
3 MED4interactorMed4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4BF849647
4 PIP4K2Bparental proteinPIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-KinaseBF849647

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