1 |
PINK1 | parental protein | 61 | 0.098 | 2349.959 | Pkinase (PF00069, IPR000719): Protein kinase domain |
2 |
AKT1 | oncoprotein | 17 | 0.333 | 59.944 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
3 |
APPL2 | interactor | 1 | 0 | 0 | PH (PF00169, IPR001849, SM00233): PH domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) BAR_3 (PF16746): BAR domain of APPL family |
4 |
BAG2 | protein found in more fusions | 8 | 0.714 | 2.417 | IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH |
5 |
BCL2L1 | oncoprotein | 7 | 0.533 | 3.817 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
6 |
BCL2L2 | oncoprotein | 2 | 1.000 | 0 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator |
7 |
CDC37 | protein found in more fusions | 10 | 0.611 | 8.986 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
8 |
COPS8 | interactor | 4 | 0.667 | 1.000 | CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family |
9 |
CRLS1 | interactor | 1 | 0 | 0 | CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162) |
10 |
DNM1L | interactor | 3 | 1.000 | 0 | Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain |
11 |
FBXO7 | interactor | 3 | 1.000 | 0 | Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal F-box-like (PF12937, IPR001810): F-box-like |
12 |
HSD17B10 | interactor | 7 | 0.619 | 4.856 | adh_short (PF00106, IPR002198): short chain dehydrogenase |
13 |
HSH2D | interactor | 1 | 0 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
14 |
HSP90AA1 | oncoprotein | 22 | 0.348 | 91.079 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
15 |
HSP90AB1 | oncoprotein | 14 | 0.577 | 15.012 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
16 |
HSPA1A | interactor | 11 | 0.509 | 18.052 | HSP70 (PF00012, IPR013126): Hsp70 protein |
17 |
HSPA1B | interactor | 4 | 0.500 | 2.333 | HSP70 (PF00012, IPR013126): Hsp70 protein |
18 |
HSPA4 | interactor | 15 | 0.429 | 32.978 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
19 |
HTRA2 | suppressor | 7 | 0.667 | 3.167 | Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32 PDZ_2 (PF13180, IPR001478): PDZ domain Trypsin_2 (PF13365): Trypsin-like peptidase domain |
20 |
IMMT | protein found in more fusions | 5 | 0.667 | 1.000 | Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein |
21 |
IRAK1 | interactor | 15 | 0.363 | 40.689 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
IRS4 | interactor | 5 | 0.800 | 0.571 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain |
23 |
KIF11 | protein found in more fusions | 2 | 0 | 0 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding |
24 |
KRAS | oncoprotein | 7 | 0.467 | 8.000 | Ras (PF00071, IPR001806, SM00173): Ras family |
25 |
MAP1B | interactor | 4 | 0.833 | 0.667 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
26 |
MAP1LC3A | interactor | 7 | 0.571 | 6.119 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
27 |
MAP3K7 | oncoprotein | 7 | 0.800 | 1.222 | Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
28 |
MAPKAP1 | interactor | 3 | 1.000 | 0 | SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1) CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology |
29 |
MARK2 | protein found in more fusions | 3 | 1.000 | 0 | DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
30 |
MCL1 | oncoprotein | 7 | 0.600 | 2.741 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family |
31 |
NAE1 | interactor | 3 | 1.000 | 0 | ThiF (PF00899, IPR000594): ThiF family |
32 |
PARK2 | suppressor | 31 | 0.186 | 303.057 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
33 |
PARK7 | suppressor | 9 | 0.500 | 7.610 | DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family |
34 |
PARL | interactor | 1 | 0 | 0 | Rhomboid (PF01694, IPR022764): Rhomboid family |
35 |
PGAM5 | interactor | 4 | 0.667 | 1.667 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) |
36 |
PRKDC | protein found in more fusions | 5 | 1.000 | 0 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
37 |
PSMC6 | interactor | 6 | 0.900 | 0.500 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain |
38 |
PSMD1 | interactor | 9 | 0.611 | 7.594 | PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats |
39 |
PSMD2 | oncoprotein | 4 | 1.000 | 0 | PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats |
40 |
PTEN | suppressor | 10 | 0.556 | 8.721 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
41 |
RB1CC1 | suppressor | 2 | 1.000 | 0 | Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain |
42 |
RHOT1 | interactor | 3 | 0.667 | 0.333 | EF_assoc_1 (PF08355, IPR013566): EF hand associated EF_assoc_2 (PF08356, IPR013567): EF hand associated Ras (PF00071, IPR001806, SM00173): Ras family EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
43 |
RHOT2 | interactor | 2 | 1.000 | 0 | EF_assoc_1 (PF08355, IPR013566): EF hand associated EF_assoc_2 (PF08356, IPR013567): EF hand associated Ras (PF00071, IPR001806, SM00173): Ras family SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region AAA_16 (PF13191): AAA ATPase domain EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
44 |
RICTOR | interactor | 5 | 0.600 | 2.286 | RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5 |
45 |
SARM1 | interactor | 4 | 0.833 | 0.500 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Carb_kinase (PF01256, IPR000631): Carbohydrate kinase SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) HEAT_2 (PF13646): HEAT repeats TIR_2 (PF13676, IPR000157): TIR domain |
46 |
SNCA | interactor | 14 | 0.474 | 23.468 | Synuclein (PF01387, IPR001058): Synuclein |
47 |
SNCAIP | protein found in more fusions | 4 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain |
48 |
SOCS4 | interactor | 1 | 0 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling SOCS_box (PF07525, IPR001496): SOCS box |
49 |
STAT3 | suppressor | 6 | 0.900 | 0.222 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
50 |
TGM2 | protein found in more fusions | 4 | 0.667 | 0.667 | Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily |
51 |
TOLLIP | interactor | 6 | 0.700 | 2.000 | C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain |
52 |
TOMM20 | interactor | 8 | 0.571 | 8.400 | RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate MAS20 (PF02064, IPR002056): MAS20 protein import receptor |
53 |
TOMM22 | interactor | 6 | 0.867 | 0.733 | Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22 |
54 |
TOMM40 | interactor | 10 | 0.533 | 13.967 | Porin_3 (PF01459, IPR027246): Eukaryotic porin |
55 |
TOMM70 | interactor | 8 | 0.607 | 5.078 | PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2 |
56 |
TRAF6 | protein found in more fusions | 18 | 0.272 | 72.700 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
57 |
TUBA1A | oncoprotein | 11 | 0.545 | 14.719 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
58 |
TUBB | interactor | 13 | 0.577 | 16.112 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
59 |
UBC | protein found in more fusions | 15 | 0.341 | 43.141 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
60 |
UBE2M | interactor | 5 | 0.667 | 2.000 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
61 |
VIM | suppressor | 6 | 0.500 | 3.917 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region |