Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PINK1 (from a repository: Thu Nov 24 19:45:04 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 61 The number (and %) of the onco-proteins 20 (32.79 %) The number (and %) of the tumor suppressors 7 (11.48 %) Total number of binary PPIs (saturation %) 263 (14.37 %) The number (and %) of affected PPIs 61 (23.19 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 7.639 Assortativity coefficient -0.3179 The network average Clustering coefficient 0.597 The number (and %) of a zero Clustering coefficients 6 (9.84 %) The number (and %) of a zero Betweenness Centrality 17 (27.87 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PINK1	All fusions : T08564; CV340510;
Proteins found in more fusions	STAT3 (see 2 fusions); TRAF6 (see 1 fusions); MCL1 (see 2 fusions); KIF11 (see 1 fusions); PRKDC (see 3 fusions); BCL2L1 (see 1 fusions); SNCAIP (see 1 fusions); IMMT (see 4 fusions); HSP90AA1 (see 2 fusions); MAP3K7 (see 7 fusions); HSP90AB1 (see 1 fusions); UBC (see 1 fusions); MARK2 (see 2 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions); PINK1 (see 3 fusions); BAG2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PINK1	parental protein	61	0.098	2349.959	Pkinase (PF00069, IPR000719): Protein kinase domain
2	AKT1	oncoprotein	17	0.333	59.944	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3	APPL2	interactor	1	0	0	PH (PF00169, IPR001849, SM00233): PH domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) BAR_3 (PF16746): BAR domain of APPL family
4	BAG2	protein found in more fusions	8	0.714	2.417	IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
5	BCL2L1	oncoprotein	7	0.533	3.817	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
6	BCL2L2	oncoprotein	2	1.000	0	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
7	CDC37	protein found in more fusions	10	0.611	8.986	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
8	COPS8	interactor	4	0.667	1.000	CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
9	CRLS1	interactor	1	0	0	CDP-OH_P_transf (PF01066, IPR000462): CDP-alcohol phosphatidyltransferase DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
10	DNM1L	interactor	3	1.000	0	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain
11	FBXO7	interactor	3	1.000	0	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal F-box-like (PF12937, IPR001810): F-box-like
12	HSD17B10	interactor	7	0.619	4.856	adh_short (PF00106, IPR002198): short chain dehydrogenase
13	HSH2D	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain
14	HSP90AA1	oncoprotein	22	0.348	91.079	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
15	HSP90AB1	oncoprotein	14	0.577	15.012	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
16	HSPA1A	interactor	11	0.509	18.052	HSP70 (PF00012, IPR013126): Hsp70 protein
17	HSPA1B	interactor	4	0.500	2.333	HSP70 (PF00012, IPR013126): Hsp70 protein
18	HSPA4	interactor	15	0.429	32.978	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
19	HTRA2	suppressor	7	0.667	3.167	Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32 PDZ_2 (PF13180, IPR001478): PDZ domain Trypsin_2 (PF13365): Trypsin-like peptidase domain
20	IMMT	protein found in more fusions	5	0.667	1.000	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
21	IRAK1	interactor	15	0.363	40.689	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
22	IRS4	interactor	5	0.800	0.571	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
23	KIF11	protein found in more fusions	2	0	0	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
24	KRAS	oncoprotein	7	0.467	8.000	Ras (PF00071, IPR001806, SM00173): Ras family
25	MAP1B	interactor	4	0.833	0.667	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
26	MAP1LC3A	interactor	7	0.571	6.119	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
27	MAP3K7	oncoprotein	7	0.800	1.222	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
28	MAPKAP1	interactor	3	1.000	0	SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1) CRIM (PF16978, IPR031567): SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH (PF16979, IPR031313): SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
29	MARK2	protein found in more fusions	3	1.000	0	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) KA1 (PF02149, IPR001772): Kinase associated domain 1 Pkinase (PF00069, IPR000719): Protein kinase domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
30	MCL1	oncoprotein	7	0.600	2.741	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
31	NAE1	interactor	3	1.000	0	ThiF (PF00899, IPR000594): ThiF family
32	PARK2	suppressor	31	0.186	303.057	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33	PARK7	suppressor	9	0.500	7.610	DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
34	PARL	interactor	1	0	0	Rhomboid (PF01694, IPR022764): Rhomboid family
35	PGAM5	interactor	4	0.667	1.667	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
36	PRKDC	protein found in more fusions	5	1.000	0	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
37	PSMC6	interactor	6	0.900	0.500	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
38	PSMD1	interactor	9	0.611	7.594	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
39	PSMD2	oncoprotein	4	1.000	0	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
40	PTEN	suppressor	10	0.556	8.721	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
41	RB1CC1	suppressor	2	1.000	0	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
42	RHOT1	interactor	3	0.667	0.333	EF_assoc_1 (PF08355, IPR013566): EF hand associated EF_assoc_2 (PF08356, IPR013567): EF hand associated Ras (PF00071, IPR001806, SM00173): Ras family EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
43	RHOT2	interactor	2	1.000	0	EF_assoc_1 (PF08355, IPR013566): EF hand associated EF_assoc_2 (PF08356, IPR013567): EF hand associated Ras (PF00071, IPR001806, SM00173): Ras family SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region AAA_16 (PF13191): AAA ATPase domain EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
44	RICTOR	interactor	5	0.600	2.286	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
45	SARM1	interactor	4	0.833	0.500	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Carb_kinase (PF01256, IPR000631): Carbohydrate kinase SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) HEAT_2 (PF13646): HEAT repeats TIR_2 (PF13676, IPR000157): TIR domain
46	SNCA	interactor	14	0.474	23.468	Synuclein (PF01387, IPR001058): Synuclein
47	SNCAIP	protein found in more fusions	4	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
48	SOCS4	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling SOCS_box (PF07525, IPR001496): SOCS box
49	STAT3	suppressor	6	0.900	0.222	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
50	TGM2	protein found in more fusions	4	0.667	0.667	Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
51	TOLLIP	interactor	6	0.700	2.000	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
52	TOMM20	interactor	8	0.571	8.400	RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate MAS20 (PF02064, IPR002056): MAS20 protein import receptor
53	TOMM22	interactor	6	0.867	0.733	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
54	TOMM40	interactor	10	0.533	13.967	Porin_3 (PF01459, IPR027246): Eukaryotic porin
55	TOMM70	interactor	8	0.607	5.078	PBP_GOBP (PF01395, IPR006170, SM00708): PBP/GOBP family TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NRBF2_MIT (PF17169): MIT domain of nuclear receptor-binding factor 2
56	TRAF6	protein found in more fusions	18	0.272	72.700	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
57	TUBA1A	oncoprotein	11	0.545	14.719	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
58	TUBB	interactor	13	0.577	16.112	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
59	UBC	protein found in more fusions	15	0.341	43.141	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
60	UBE2M	interactor	5	0.667	2.000	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61	VIM	suppressor	6	0.500	3.917	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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