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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)145
The number (and %) of the onco-proteins92 (63.45 %)
The number (and %) of the tumor suppressors2 (1.38 %)
Total number of binary PPIs (saturation %)1014 (9.71 %)
The number (and %) of affected PPIs145 (14.30 %)
The number of possible different fusions37
PPI diameter2
PPI radius1
The average degree of PPI13.145
Assortativity coefficient-0.2515
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients14 (9.66 %)
The number (and %) of a zero Betweenness Centrality32 (22.07 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIK3R1 All fusions
: BU742563;
Proteins found in more fusions PTPN11 (see 1 fusions); SYK (see 1 fusions); YWHAG (see 1 fusions); GAB2 (see 2 fusions); ZDHHC17 (see 2 fusions); CBL (see 1 fusions); NPM1 (see 1 fusions); JAK2 (see 3 fusions); CUL3 (see 1 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); LCK (see 1 fusions); FYN (see 1 fusions); FER (see 1 fusions); TNFRSF1A (see 2 fusions); ERBB3 (see 1 fusions); STAT3 (see 2 fusions); SYN1 (see 1 fusions); SELPLG (see 2 fusions); CD40 (see 1 fusions); KHDRBS1 (see 1 fusions); EZR (see 2 fusions); SH3KBP1 (see 1 fusions); PDE4D (see 2 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); HTT (see 1 fusions); RXRA (see 2 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); EP300 (see 1 fusions); MAP3K5 (see 1 fusions); FGFR1 (see 1 fusions); FGFR2 (see 3 fusions); CBLB (see 3 fusions); NCL (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIK3R1parental protein1450.07912813.777RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
2 ABI1oncoprotein51.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 ABL1oncoprotein330.371135.086Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ADAM12interactor100Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
5 ADAMTS2interactor100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
6 AGAP2interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ras (PF00071, IPR001806, SM00173): Ras family
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
7 ALKoncoprotein130.43615.216MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
8 ALOX5oncoprotein21.0000Lipoxygenase (PF00305, IPR013819): Lipoxygenase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
9 APPL1interactor140.37228.384ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
10 ARAFoncoprotein30.6671.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 ARHGAP1interactor50.6671.333RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
12 ARHGAP17interactor80.7501.036BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
13 ARHGAP32oncoprotein130.6674.777PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
14 AXLoncoprotein70.6193.893fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2627 (PF11118, IPR020138): Protein of unknown function (DUF2627)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
15 BCAR1oncoprotein200.47931.527Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
16 BRCA1oncoprotein100.4179.259BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
17 CBLoncoprotein560.253584.302Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
18 CBLBoncoprotein250.50039.348Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
19 CCL14interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
20 CD244interactor21.0000Receptor_2B4 (PF11465, IPR024303): Natural killer cell receptor 2B4
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
21 CD28interactor60.7331.282V-set_2 (PF15910, IPR013106): ICOS V-set domain
22 CD3Einteractor80.5005.619ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif
P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter
Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
23 CD40protein found in more fusions41.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
24 CD7interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
25 CHAF1Ainteractor40.6670.500CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
26 CLNKinteractor60.8670.619SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
27 CMIPinteractor100PH (PF00169, IPR001849, SM00233): PH domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
Microtub_bd (PF16796, IPR031852): Microtubule binding
28 CRKoncoprotein420.279265.041SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
29 CRKLoncoprotein290.41964.024SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 CSF1Roncoprotein90.6941.626ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
31 CSF2RAinteractor21.0000IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
32 CTNNB1oncoprotein200.29577.257Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
33 CUL3protein found in more fusions130.53012.098Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
34 CXCL2interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
35 CYP4A11interactor100p450 (PF00067, IPR001128): Cytochrome P450
36 DAB2IPoncoprotein50.4003.267C2 (PF00168, IPR000008, SM00239): C2 domain
PH_2 (PF08458, IPR013666): Plant pleckstrin homology-like region
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
37 DLX2interactor200Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
38 DOK1suppressor150.6159.427IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
39 EFNB2interactor50.6002.000Ephrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
40 EGFRoncoprotein580.246599.170Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
41 EP300oncoprotein130.39424.785Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
42 EPHA2oncoprotein110.6449.454fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
43 EPN1interactor60.5333.440ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
44 EPORoncoprotein130.6156.874EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
45 ERBB2oncoprotein340.390138.570Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
46 ERBB3oncoprotein240.44355.396Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
47 ESR1oncoprotein230.32080.412Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
48 EZRprotein found in more fusions90.5365.421DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
49 FASLGinteractor110.41814.247PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
50 FBXL2interactor21.0000Ste50p-SAM (PF09235, IPR015316): Ste50p, sterile alpha motif
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
51 FCGR2Ainteractor50.8000.375DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
52 FERprotein found in more fusions70.8670.536DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain
PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Med29 (PF11568, IPR021018): Mediator complex subunit 29
53 FESoncoprotein41.0000FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
54 FGFR1oncoprotein130.40912.488I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
55 FGFR2oncoprotein51.0000Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
56 FLT3oncoprotein50.8330.118I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
57 FYNoncoprotein340.242185.349Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
58 GAB1oncoprotein100.8890.579PH (PF00169, IPR001849, SM00233): PH domain
59 GAB2oncoprotein180.47818.125PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
60 GNAQoncoprotein21.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
61 GRB10oncoprotein110.45512.136BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
62 GRB2oncoprotein690.211955.284SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
63 GSPT1oncoprotein21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
64 HCSTinteractor100DAP10 (PF07213, IPR009861): DAP10 membrane protein
65 HDAC3oncoprotein100.50010.324Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
66 HOXA1interactor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
67 HRASoncoprotein70.4766.036Ras (PF00071, IPR001806, SM00173): Ras family
68 HTTprotein found in more fusions80.3818.552HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
69 IFNAR1oncoprotein30.6670.200Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
70 IGF1Roncoprotein160.55814.968fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
71 IL1R1interactor100TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
72 IL6SToncoprotein100.7332.001fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
73 INPP5Dinteractor150.49525.195Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
74 INPPL1oncoprotein130.6928.547Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
75 IRS1interactor210.45239.604CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
76 IRS2oncoprotein140.46221.931CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
77 IRS4interactor130.48718.769CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
78 ITSN1interactor100.4727.834C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
79 JAK2oncoprotein250.42859.663FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
80 KHDRBS1protein found in more fusions180.35325.089KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
81 KIToncoprotein200.42646.742ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
82 LATinteractor150.54316.882LAT (PF15234, IPR008359): Linker for activation of T-cells
83 LCKoncoprotein250.23693.595Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
84 LCP2interactor130.6925.915SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SDA1 (PF05285, IPR007949): SDA1
SH2 (PF00017, IPR000980, SM00252): SH2 domain
85 LTKinteractor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
86 MAP3K5protein found in more fusions80.5246.550Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
87 MED28interactor60.8000.191cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
88 NCK1oncoprotein240.31269.016SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
89 NCLprotein found in more fusions80.6673.562DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
90 NFKBIAoncoprotein50.6003.667Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
91 NPM1oncoprotein120.49115.662Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
92 NTRK1oncoprotein400.270290.381I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
93 NTRK2oncoprotein50.5001.820I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
94 NYAP2interactor100NYAP_N (PF15439): Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
TMEM247 (PF15444, IPR029200): Transmembrane protein 247
NYAP_C (PF15452, IPR029353): Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
95 PCBP1oncoprotein50.7001.033Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
96 PDE4Doncoprotein80.4764.890Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
97 PDGFRAoncoprotein120.6554.779Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
98 PDGFRBoncoprotein150.6046.540I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
99 PECAM1oncoprotein90.4643.913C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
100 PIK3CAoncoprotein220.277102.536PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
101 PIK3CBoncoprotein160.40039.401PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
102 PIK3CDoncoprotein50.5003.833PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
103 PIK3R2oncoprotein400.262338.207RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
104 PLCG2interactor110.6363.599C2 (PF00168, IPR000008, SM00239): C2 domain
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
105 PRMT2interactor40.5001.667PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
106 PTGER3interactor40.8330.2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
107 PTK2protein found in more fusions250.50739.329FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
108 PTPN11oncoprotein350.358137.854SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
109 PTPN6oncoprotein180.47723.782SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
110 PXKinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PX (PF00787, IPR001683, SM00312): PX domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
MNR (PF15718, IPR031447): Protein moonraker
111 PXNoncoprotein140.6047.517LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
112 RAB5Aoncoprotein50.5002.119Ras (PF00071, IPR001806, SM00173): Ras family
113 RRAS2oncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
114 RXRAoncoprotein60.7001.015zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
115 SELPLGprotein found in more fusions31.0000EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF4689 (PF15755, IPR031499): Domain of unknown function (DUF4689)
116 SH2D2Ainteractor90.7782.275SH2 (PF00017, IPR000980, SM00252): SH2 domain
117 SH3KBP1protein found in more fusions260.39086.206Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
118 SHBinteractor100.6893.824Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
119 SHC1oncoprotein350.339142.423PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
120 SIRT1oncoprotein90.6073.874DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
121 SOCS1oncoprotein220.36462.616SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
122 SOCS6interactor80.6793.268SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
123 SOS1oncoprotein220.41148.421Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
124 SQSTM1oncoprotein120.32726.208PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
125 SRConcoprotein460.229407.086Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
126 STAT3oncoprotein290.310136.521SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
127 SYKoncoprotein300.372116.346Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
128 SYN1protein found in more fusions51.0000Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
129 SYNMsuppressor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
130 TGFBR1oncoprotein70.4295.650Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
131 TGFBR2oncoprotein100.4679.731ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
132 TLR3interactor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
133 TMEM17interactor80.25013.133Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
134 TNFRSF1Aoncoprotein160.50520.263Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
135 TNIP1interactor50.5003.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
136 TNS4interactor40.8330.111PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
137 TTRinteractor200Transthyretin (PF00576, IPR023416, SM00095): HIUase/Transthyretin family
138 TUBA1Binteractor50.8000.500Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
139 TYRO3oncoprotein40.6672.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
140 VAV1oncoprotein250.41060.755PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
141 VSIG4interactor31.0000EMP70 (PF02990, IPR004240): Endomembrane protein 70
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
142 WASoncoprotein120.5766.352CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
143 YWHAGprotein found in more fusions120.41820.63414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
144 ZAP70interactor200.52029.706Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
145 ZDHHC17protein found in more fusions60.4003.733zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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