Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIAS2 (from a repository: Sun Dec 4 03:41:28 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins21 (29.58 %)
The number (and %) of the tumor suppressors15 (21.13 %)
Total number of binary PPIs (saturation %)301 (12.11 %)
The number (and %) of affected PPIs71 (23.59 %)
The number of possible different fusions17
PPI diameter2
PPI radius1
The average degree of PPI7.183
Assortativity coefficient-0.4493
The network average Clustering coefficient0.583
The number (and %) of a zero Clustering coefficients11 (15.49 %)
The number (and %) of a zero Betweenness Centrality28 (39.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIAS2 All fusions
: AA244416; AA244401;
Proteins found in more fusions CTBP1 (see 2 fusions); SMAD4 (see 2 fusions); PIAS1 (see 2 fusions); NR3C1 (see 8 fusions); GFAP (see 3 fusions); SIAH2 (see 1 fusions); HUWE1 (see 2 fusions); SIAH1 (see 4 fusions); PML (see 4 fusions); ZNF451 (see 1 fusions); MYC (see 1 fusions); GLUL (see 4 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); PIAS2 (see 2 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIAS2parental protein710.0773324.994SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
2 ACY3interactor200AstE_AspA (PF04952, IPR007036): Succinylglutamate desuccinylase / Aspartoacylase family
3 ADAinteractor21.0000A_deaminase (PF00962, IPR001365): Adenosine/AMP deaminase
4 AKT1oncoprotein110.40018.601PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 ARoncoprotein130.53013.727Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6 ARNToncoprotein21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_11 (PF14598): PAS domain
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
7 C1QAoncoprotein100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
8 CCHCR1interactor50.5002.167HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
9 CCNDBP1suppressor30.6670.667CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
10 CDCA8interactor31.0000Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
11 CDKN2Asuppressor70.7622.233Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 CDKN2Bsuppressor100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
13 CHMP4Binteractor41.0000Snf7 (PF03357, IPR005024): Snf7
14 CLDN2interactor21.0000PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
DUF4064 (PF13273, IPR025273): Protein of unknown function (DUF4064)
15 CTBP1protein found in more fusions60.6001.6862-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
16 DNMT3Asuppressor40.8330.286DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
17 ESR1suppressor130.39431.875Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
18 ESR2suppressor31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
19 FLI1oncoprotein50.7001.002Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
20 GFAPprotein found in more fusions50.5001.833Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
21 GLULprotein found in more fusions41.0000Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain
Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
22 GOLGA2interactor60.4007.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
23 GTF2Iinteractor41.0000GTF2I (PF02946, IPR004212): GTF2I-like repeat
24 GTF2IRD1interactor100GTF2I (PF02946, IPR004212): GTF2I-like repeat
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
25 HIC1suppressor60.7001.100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
26 HUWE1oncoprotein51.0000BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
27 IFIH1interactor100ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
28 JUNoncoprotein160.41041.984bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
29 LMNB1interactor100Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
30 MAPK8oncoprotein90.5717.387DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
31 MAPKAPK2oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
32 MBD1interactor21.0000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
33 MITFoncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal
MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
34 MSX2interactor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
35 MX2interactor200Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
36 MYConcoprotein130.53017.321HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
37 NAV2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_14 (PF13173): AAA domain
38 NR3C1protein found in more fusions100.55613.621GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
39 PARK7suppressor80.7142.172DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
40 PAXIP1interactor40.5002.167BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
41 PGRsuppressor31.0000Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
42 PHC1interactor60.8000.900GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
FSA_C (PF10479, IPR018863): Fragile site-associated protein C-terminus
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
43 PIAS1suppressor280.225183.116Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
44 PIAS4interactor110.47314.114CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
45 PLAG1oncoprotein40.6670.382zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
46 PLAGL1suppressor50.9000.154zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
47 PMLsuppressor190.38655.308zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
48 PRKAB2interactor40.6670.667AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
49 RUFY1interactor200DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
50 SIAH1suppressor100.6117.633Sina (PF03145, IPR018121): Seven in absentia protein family
51 SIAH2oncoprotein80.6674.250Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
52 SMAD3oncoprotein170.35841.779MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
53 SMAD4suppressor100.7223.163MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
54 SREBF2protein found in more fusions60.6001.021HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
55 STAT4interactor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
56 SUMO1interactor150.46225.239Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
57 SUMO1P1interactor70.6004.333NA
58 SUMO2interactor90.5716.286Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
59 SUMO3interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
60 TICAM2interactor100TIR_2 (PF13676, IPR000157): TIR domain
61 TP53suppressor220.32983.456DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
62 TRAF2interactor80.33312.167MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
63 TRIM23interactor60.8001.167Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
64 TRIM27oncoprotein120.45522.386IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
65 TRIM55interactor60.9000.500Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
66 TRIM63interactor60.9000.500DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
67 TSR2interactor100WGG (PF10273, IPR019398): Pre-rRNA-processing protein TSR2
68 UBE2Iinteractor410.167497.035UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
69 ZBED1interactor41.0000Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
70 ZBTB8Ainteractor50.6671.333BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
71 ZNF451protein found in more fusions70.8000.956zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

B a c k    t o    T o p ⇑