Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PIAS1 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 98 The number (and %) of the onco-proteins 51 (52.04 %) The number (and %) of the tumor suppressors 7 (7.14 %) Total number of binary PPIs (saturation %) 523 (11.00 %) The number (and %) of affected PPIs 98 (18.74 %) The number of possible different fusions 26 PPI diameter 2 PPI radius 1 The average degree of PPI 9.592 Assortativity coefficient -0.3610 The network average Clustering coefficient 0.583 The number (and %) of a zero Clustering coefficients 6 (6.12 %) The number (and %) of a zero Betweenness Centrality 22 (22.45 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PIAS1	All fusions : AA287842; CR933617;
Proteins found in more fusions	ZMYND11 (see 1 fusions); SMAD4 (see 2 fusions); TRIM27/MDM2 (see 1 fusions); GSK3B (see 1 fusions); ATXN1 (see 3 fusions); SIAH1 (see 1 fusions); CREB1 (see 2 fusions); GLUL (see 4 fusions); PIAS2 (see 2 fusions); SREBF2 (see 2 fusions); PSME3 (see 2 fusions); PIAS1 (see 2 fusions); YWHAZ (see 1 fusions); SRSF1 (see 1 fusions); HTT (see 1 fusions); CSNK2A1 (see 1 fusions); SIAH2 (see 1 fusions); PTK2 (see 2 fusions); DDX5 (see 1 fusions); PML (see 4 fusions); PRPF40A (see 2 fusions); ZNF451 (see 1 fusions); STAT1 (see 1 fusions); CBS (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PIAS1	parental protein	98	0.080	5869.835	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
2	AKT1	oncoprotein	17	0.358	32.571	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3	AR	oncoprotein	22	0.329	83.818	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	ATXN1	protein found in more fusions	9	0.536	8.875	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
5	ATXN7	interactor	6	0.667	1.505	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) SCA7 (PF08313, IPR013243): SCA7, zinc-binding domain Macoilin (PF09726, IPR019130): Transmembrane protein DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505) IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
6	BARD1	oncoprotein	10	0.556	9.450	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7	BRCA1	oncoprotein	23	0.329	85.837	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
8	CASP8AP2	interactor	9	0.571	5.800	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
9	CBS	protein found in more fusions	3	1.000	0	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
10	CEBPA	oncoprotein	8	0.619	3.654	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
11	CEBPE	interactor	6	0.700	1.667	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
12	CEP250	interactor	2	1.000	0	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13	CHUK	suppressor	12	0.564	8.619	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
14	CREB1	oncoprotein	16	0.381	37.383	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function
15	CSNK2A1	oncoprotein	14	0.397	22.934	Pkinase (PF00069, IPR000719): Protein kinase domain
16	CSRP2	interactor	3	0.667	0.500	LIM (PF00412, IPR001781, SM00132): LIM domain
17	DCLRE1A	interactor	1	0	0	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase Glyco_hydro_45 (PF02015, IPR000334): Glycosyl hydrolase family 45 Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
18	DDX5	oncoprotein	10	0.556	10.567	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
19	DNM1	interactor	4	1.000	0	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
20	DNMT3A	oncoprotein	4	0.833	0.500	DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase PWWP (PF00855, IPR000313, SM00293): PWWP domain
21	DNMT3B	suppressor	5	0.700	1.452	DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase PWWP (PF00855, IPR000313, SM00293): PWWP domain
22	ERP44	interactor	3	0.667	1.000	Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
23	ESR1	oncoprotein	27	0.280	138.482	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
24	FLI1	oncoprotein	5	0.800	0.700	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
25	FOXA1	oncoprotein	4	0.500	1.182	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region HNF_C (PF09354, IPR018533): HNF3 C-terminal domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
26	FRAT1	oncoprotein	2	1.000	0	GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding
27	GLUL	protein found in more fusions	7	0.600	2.686	Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
28	GSK3B	oncoprotein	14	0.449	24.522	Pkinase (PF00069, IPR000719): Protein kinase domain
29	HECTD2	interactor	1	0	0	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
30	HIC1	oncoprotein	4	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
31	HIF1A	suppressor	7	0.905	0.315	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
32	HTT	protein found in more fusions	11	0.422	14.276	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
33	ID1	interactor	2	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
34	JUN	oncoprotein	22	0.381	60.510	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
35	KLC1	interactor	2	1.000	0	Gly_radical (PF01228, IPR001150): Glycine radical SOGA (PF11365, IPR027881): Protein SOGA TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
36	L3MBTL2	interactor	2	1.000	0	MBT (PF02820, IPR004092, SM00561): mbt repeat
37	MAML1	interactor	1	0	0	MamL-1 (PF09596, IPR019082): MamL-1 domain Kri1 (PF05178, IPR018034): KRI1-like family PRIMA1 (PF16101): Proline-rich membrane anchor 1
38	MBD1	interactor	4	0.500	1.400	MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
39	MDC1	oncoprotein	13	0.410	28.034	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
40	MDM2	oncoprotein	20	0.404	46.977	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
41	MITF	oncoprotein	4	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
42	MX1	interactor	6	0.800	0.786	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
43	MYB	oncoprotein	8	0.607	5.322	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
44	NCOA3	oncoprotein	14	0.374	31.545	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
45	NCOR1	oncoprotein	25	0.290	130.694	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
46	NFATC1	oncoprotein	6	0.867	0.419	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
47	NR1H2	oncoprotein	5	0.600	1.700	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
48	NR1H3	interactor	4	0.667	0.800	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
49	PAXIP1	interactor	8	0.357	9.067	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
50	PIAS2	protein found in more fusions	28	0.225	178.888	SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
51	PLAG1	oncoprotein	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
52	PML	oncoprotein	26	0.303	110.995	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
53	POLK	interactor	1	0	0	ATP-cone (PF03477, IPR005144): ATP cone domain IMS (PF00817, IPR001126): impB/mucB/samB family IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
54	PPARG	oncoprotein	13	0.409	22.163	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
55	PPARGC1A	interactor	7	0.667	2.094	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
56	PPARGC1B	interactor	4	0.500	1.050	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein Mak16 (PF04874, IPR006958): Mak16 protein C-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
57	PPP1CA	oncoprotein	14	0.560	14.733	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
58	PPP1CC	oncoprotein	9	0.500	9.567	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
59	PRDM1	oncoprotein	3	1.000	0	SET (PF00856, IPR001214, SM00317): SET domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
60	PRPF40A	protein found in more fusions	12	0.291	27.239	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
61	PSME3	protein found in more fusions	9	0.536	9.219	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
62	PTK2	protein found in more fusions	8	0.571	7.067	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
63	RAD54L2	interactor	8	0.500	5.271	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain FAM176 (PF14851): FAM176 family ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
64	RBBP6	oncoprotein	6	0.800	1.567	DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936) DWNN (PF08783, IPR014891): DWNN domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region U-box (PF04564, IPR003613, SM00504): U-box domain SBF2 (PF12335, IPR022096): Myotubularin protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 PRIMA1 (PF16101): Proline-rich membrane anchor 1
65	SAFB	suppressor	6	0.667	2.622	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
66	SATB1	oncoprotein	6	0.733	3.000	CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
67	SERBP1	interactor	6	0.800	0.472	HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
68	SGTA	interactor	1	0	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
69	SHFM1	interactor	5	0.800	0.900	CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
70	SIAH1	suppressor	13	0.424	22.108	Sina (PF03145, IPR018121): Seven in absentia protein family
71	SIAH2	oncoprotein	8	0.667	3.217	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
72	SKIL	oncoprotein	9	0.571	5.858	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
73	SMAD1	interactor	9	0.500	9.950	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
74	SMAD4	oncoprotein	14	0.449	22.372	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
75	SMAD7	interactor	5	0.700	0.783	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
76	SOX2	oncoprotein	5	0.667	0.722	HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box SOXp (PF12336, IPR022097): SOX transcription factor
77	SP3	interactor	4	1.000	0	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
78	SPOP	oncoprotein	5	0.833	0.154	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain MATH (PF00917, IPR002083, SM00061): MATH domain
79	SREBF2	protein found in more fusions	7	0.600	2.538	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
80	SRSF1	protein found in more fusions	12	0.527	14.183	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
81	STAB2	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Fasciclin (PF02469, IPR000782, SM00554): Fasciclin domain Xlink (PF00193, IPR000538, SM00445): Extracellular link domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
82	STAT1	suppressor	9	0.536	8.150	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
83	SUMO1	interactor	23	0.260	105.358	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
84	SUMO2	interactor	14	0.372	27.088	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
85	SUMO3	interactor	4	1.000	0	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
86	TERF2	interactor	6	0.700	1.400	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
87	TP53	oncoprotein	38	0.231	319.852	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
88	TRIM27	oncoprotein	12	0.509	16.438	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
89	TRIM5	interactor	3	1.000	0	Baculo_IE-1 (PF05290, IPR007954): Baculovirus immediate-early protein (IE-0) Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
90	TRIM55	interactor	8	0.571	5.067	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein NABP (PF07990, IPR012940): Nucleic acid binding protein NABP zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
91	TRIM63	interactor	6	0.900	0.500	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) KIP1 (PF07765, IPR011684): KIP1-like protein RED_C (PF07807, IPR012492): RED-like protein C-terminal region zf-HIT (PF04438, IPR007529): HIT zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
92	UBE2I	interactor	55	0.156	887.542	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
93	VPS16	interactor	3	0.667	1.000	Vps16_C (PF04840, IPR006925): Vps16, C-terminal region Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
94	YWHAZ	protein found in more fusions	11	0.400	21.315	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
95	ZMIZ2	interactor	3	1.000	0	zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
96	ZMYND11	suppressor	7	0.800	1.400	DUF1002 (PF06207, IPR009343): Protein of unknown function (DUF1002) DUF1353 (PF07087, IPR010767): Protein of unknown function (DUF1353) PWWP (PF00855, IPR000313, SM00293): PWWP domain zf-MYND (PF01753, IPR002893): MYND finger zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
97	ZNF451	protein found in more fusions	10	0.528	6.775	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type EPL1 (PF10513, IPR019542): Enhancer of polycomb-like zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-met (PF12874): Zinc-finger of C2H2 type zf-C2H2_4 (PF13894): C2H2-type zinc finger Cys_rich_KTR (PF14205, IPR025957): Cysteine-rich KTR FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
98	ZNF76	interactor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type CopK (PF11525, IPR021604): Copper resistance protein K DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain DUF4376 (PF14301, IPR025484): Domain of unknown function (DUF4376)

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