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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins20 (35.09 %)
The number (and %) of the tumor suppressors2 (3.51 %)
Total number of binary PPIs (saturation %)229 (14.35 %)
The number (and %) of affected PPIs57 (24.89 %)
The number of possible different fusions16
PPI diameter2
PPI radius1
The average degree of PPI7.158
Assortativity coefficient-0.2803
The network average Clustering coefficient0.492
The number (and %) of a zero Clustering coefficients8 (14.04 %)
The number (and %) of a zero Betweenness Centrality15 (26.32 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PFKM All fusions
Proteins found in more fusions PFKL (see 2 fusions); EGFR/PTPRF (see 1 fusions); PFKM (see 1 fusions); APEH (see 1 fusions); CTH (see 3 fusions); CUL3 (see 1 fusions); KIF11 (see 1 fusions); PCNA (see 1 fusions); SIAH1 (see 4 fusions); TRIM25 (see 2 fusions); SFPQ (see 6 fusions); MAPK1 (see 1 fusions); EEF1A1 (see 1 fusions); EGFR (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PFKMparental protein570.0962137.167PFK (PF00365, IPR000023): Phosphofructokinase
2 APEHoncoprotein60.6001.869Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 ARFIP1interactor50.6002.900Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
4 ARFIP2interactor60.6003.333Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ARHGDIAinteractor80.5716.452Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
6 ATP6V0A4interactor100V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
7 AURKAoncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
8 CAPZA2interactor50.4005.000F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
9 CAV3interactor30.6670.333Caveolin (PF01146, IPR001612): Caveolin
10 CDC5Linteractor120.50914.419OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
11 CKAP5interactor70.6002.452HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
12 COMMD4interactor40.6671.333COMM_domain (PF07258): COMM domain
13 CPPED1interactor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
14 CTHprotein found in more fusions200Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
15 CUL3protein found in more fusions140.44923.007Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
16 DCP1Ainteractor50.4004.667DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
17 DCP2interactor21.0000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
18 EEF1A1suppressor160.40042.662GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
19 EGFRoncoprotein160.31449.571Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 ELAC2oncoprotein60.6003.233Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
21 ELMSAN1interactor100ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
22 FAM98Ainteractor50.7000.936DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465)
23 FBXO6interactor100.46711.405FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
24 FERMT2interactor60.6004.333FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
25 FHL2oncoprotein60.5004.167LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
26 HGSinteractor70.4766.569FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
27 HPF1interactor21.0000DUF2228 (PF10228, IPR019361): Uncharacterised conserved protein (DUF2228)
28 KIF11protein found in more fusions60.7000.886Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
29 LSM7interactor100LSM (PF01423, IPR001163): LSM domain
30 MAPK1oncoprotein90.42912.000Pkinase (PF00069, IPR000719): Protein kinase domain
31 MAPK3oncoprotein50.6671.167Pkinase (PF00069, IPR000719): Protein kinase domain
32 MCFD2interactor21.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
33 MOV10interactor90.41713.200AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
34 NDUFB2interactor100NADH_B2 (PF14813): NADH dehydrogenase 1 beta subcomplex subunit 2
35 NTRK1oncoprotein280.242196.812I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36 NXF1interactor100.36112.767NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
37 PCBP1oncoprotein90.50010.805Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
38 PCNAoncoprotein90.6075.352PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
39 PFKLprotein found in more fusions110.46717.021PFK (PF00365, IPR000023): Phosphofructokinase
40 PFKPinteractor170.36062.845PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
41 PICALMoncoprotein110.38226.717ANTH (PF07651, IPR011417): ANTH domain
42 PKMoncoprotein90.6117.905PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
43 PRRC1interactor30.6671.000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
44 PSMD5interactor21.0000Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
45 PSMG1interactor60.5004.333PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
46 PTPRFprotein found in more fusions50.8000.900Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
47 SARSinteractor80.35714.467NOD (PF06816, IPR010660): NOTCH protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
48 SFPQoncoprotein100.44412.119GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
49 SIAH1suppressor200Sina (PF03145, IPR018121): Seven in absentia protein family
50 SNW1protein found in more fusions170.35847.921SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
51 SUMO2interactor31.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
52 SUMO3interactor40.5001.452Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
53 TRIM25protein found in more fusions70.4675.400Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
54 TUBB2Ainteractor50.5001.971Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
55 UBTD1interactor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
UBD (PF16455, IPR032752): Ubiquitin-binding domain
56 XPO6interactor40.5001.150IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
57 YOD1interactor100OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain

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