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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PFKL (from a repository: Thu Nov 17 18:35:36 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins17 (33.33 %)
The number (and %) of the tumor suppressors2 (3.92 %)
Total number of binary PPIs (saturation %)210 (16.47 %)
The number (and %) of affected PPIs51 (24.29 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI7.098
Assortativity coefficient-0.3268
The network average Clustering coefficient0.498
The number (and %) of a zero Clustering coefficients7 (13.73 %)
The number (and %) of a zero Betweenness Centrality12 (23.53 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: PFKL All fusions
: BI024780; BI060191;
Proteins found in more fusions PFKL (see 2 fusions); CUL7 (see 2 fusions); ATN1 (see 1 fusions); PFKM (see 1 fusions); APEH (see 1 fusions); PYGB (see 1 fusions); APP (see 4 fusions); FUS/PKM (see 1 fusions); STAU1 (see 2 fusions); PRPF40A (see 2 fusions); EGFR (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PFKLparental protein510.1071743.455PFK (PF00365, IPR000023): Phosphofructokinase
2 ABCE1interactor70.4004.622ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ADSSinteractor100Adenylsucc_synt (PF00709, IPR001114, SM00788): Adenylosuccinate synthetase
4 APEHoncoprotein41.0000Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
5 APPprotein found in more fusions110.28926.089APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ASS1suppressor60.6003.500Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
7 ATG101interactor100ATG101 (PF07855, IPR012445): Autophagy-related protein 101
8 ATN1protein found in more fusions40.6671.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
9 CCDC8interactor90.6792.991Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CEP162interactor100DivIC (PF04977, IPR007060): Septum formation initiator
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553)
DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
11 COPS6interactor60.7001.056DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
12 CUL7protein found in more fusions140.44922.891ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
13 DMWDinteractor30.6671.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 EGFRoncoprotein120.45514.161Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
15 FAF2interactor80.6193.883DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
16 FBXO6interactor110.40019.497FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
17 FN1oncoprotein100.46715.244fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
18 FOXP4interactor200TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
19 FUSsuppressor110.58211.108Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
20 GTPBP3interactor200TrmE_N (PF10396, IPR018948): GTP-binding protein TrmE N-terminus
MnmE_helical (PF12631, IPR025867): MnmE helical domain
21 HDAC6oncoprotein70.6674.222Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
22 ITGA4interactor90.5007.717FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
23 KRTAP10-7interactor40.6671.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
24 KRTAP4-12interactor40.6671.000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
25 KRTAP5-9interactor30.6671.000Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
26 MTHFD1interactor90.5287.808FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
27 MYD88oncoprotein31.0000Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
28 NTRK1oncoprotein190.31470.147I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
29 PCBP3interactor100KH_1 (PF00013, IPR004088, SM00322): KH domain
30 PFKMprotein found in more fusions110.46714.911PFK (PF00365, IPR000023): Phosphofructokinase
31 PFKPinteractor180.35365.549PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
32 PKMoncoprotein150.43832.297PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
33 PRDX3interactor60.5003.333AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
34 PRPF40Aprotein found in more fusions80.4769.267FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
35 PSMD2oncoprotein120.33329.386PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
36 PSMD5interactor60.4005.633Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
37 PSMD9interactor40.6671.667Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
38 PSMG1interactor50.8330.333PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
39 PYGBprotein found in more fusions40.6670.500Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
40 PYGLinteractor60.4004.333Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
41 RAD21oncoprotein50.8000.900Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
42 RNF2interactor80.3818.333zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
43 SNW1protein found in more fusions120.47316.683SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
44 STAU1protein found in more fusions120.47317.586dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
45 TAF10interactor21.0000TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
46 TAF13interactor21.0000TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
47 TERF2interactor60.4005.667Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
48 TESK1interactor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
49 TSNAXinteractor30.6671.000Translin (PF01997, IPR002848): Translin family
50 YWHAQinteractor100.5787.23014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
51 ZC3HC1interactor21.0000Rsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADSSinteractorAdenylsucc_synt (PF00709, IPR001114, SM00788): Adenylosuccinate synthetaseBI024780, BI060191
2 APEHoncoproteinPeptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase familyBI024780, BI060191
3 ATN1interactorAtrophin-1 (PF03154, IPR002951): Atrophin-1 familyBI024780, BI060191
4 KRTAP4-12interactorKeratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 proteinBI024780, BI060191
5 PFKLparental proteinPFK (PF00365, IPR000023): PhosphofructokinaseBI024780, BI060191
6 TAF13interactorTFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunitBI024780, BI060191
7 TESK1interactorPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinaseBI024780, BI060191
8 TSNAXinteractorTranslin (PF01997, IPR002848): Translin familyBI024780, BI060191

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