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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins3 (20.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)34 (32.38 %)
The number (and %) of affected PPIs15 (44.12 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.600
Assortativity coefficient-0.2571
The network average Clustering coefficient0.552
The number (and %) of a zero Clustering coefficients4 (26.67 %)
The number (and %) of a zero Betweenness Centrality8 (53.33 %)


List of the fusions

PPI for parental proteins: PEX10 All fusions
: BF913228;
Proteins found in more fusions HNRNPD (see 1 fusions); PEX14 (see 1 fusions); PEX10 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PEX10parental protein150.143144.333Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 CGRRF1interactor100zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
3 CLCN2interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
4 HDAC1suppressor50.6672.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
5 HNRNPDoncoprotein41.0000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
7 MKRN3oncoprotein40.6671.000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
8 PCGF6interactor31.0000DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
9 PEX12interactor40.8330.667Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 PEX14protein found in more fusions60.7002.333HemX (PF04375, IPR007470): HemX, putative uroporphyrinogen-III C-methyltransferase
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
11 PEX19interactor31.0000Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
12 PEX2interactor31.0000C1_2 (PF03107, IPR004146): C1 domain
Pex2_Pex12 (PF04757, IPR006845): Pex2 / Pex12 amino terminal region
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
13 PEX5interactor50.6003.667TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
14 PHKG2interactor100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
15 UBE2Iinteractor50.6672.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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