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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins6 (46.15 %)
The number (and %) of the tumor suppressors2 (15.38 %)
Total number of binary PPIs (saturation %)21 (26.92 %)
The number (and %) of affected PPIs13 (61.90 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5270
The network average Clustering coefficient0.155
The number (and %) of a zero Clustering coefficients10 (76.92 %)
The number (and %) of a zero Betweenness Centrality12 (92.31 %)


List of the fusions

PPI for parental proteins: PDLIM2 All fusions
: BG419413;
Proteins found in more fusions PDLIM2 (see 1 fusions); FGFR2 (see 3 fusions); UBE2E2 (see 1 fusions); APC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 PDLIM2parental protein130.015130.000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
2 ACDinteractor21.0000TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
3 APCsuppressor200APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 AURKAoncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
5 BAG4interactor100BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
6 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
7 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
8 FGFR4oncoprotein200APH (PF01636, IPR002575): Phosphotransferase enzyme family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
9 POT1interactor31.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
10 RAF1oncoprotein200Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 STAT4interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
12 TGFB1suppressor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
13 UBE2E2protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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