Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins PCNA (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 274 The number (and %) of the onco-proteins 116 (42.34 %) The number (and %) of the tumor suppressors 13 (4.74 %) Total number of binary PPIs (saturation %) 2245 (6.00 %) The number (and %) of affected PPIs 274 (12.20 %) The number of possible different fusions 49 PPI diameter 2 PPI radius 1 The average degree of PPI 15.606 Assortativity coefficient -0.2103 The network average Clustering coefficient 0.458 The number (and %) of a zero Clustering coefficients 16 (5.84 %) The number (and %) of a zero Betweenness Centrality 40 (14.60 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: PCNA	All fusions : BM462208;
Proteins found in more fusions	U2AF2 (see 2 fusions); WHSC1 (see 1 fusions); CUL1 (see 3 fusions); FANCL (see 2 fusions); LAMP2 (see 1 fusions); TNFAIP1 (see 1 fusions); EWSR1 (see 2 fusions); PRKDC (see 3 fusions); APC (see 1 fusions); FANCA (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); PCNA (see 1 fusions); MSH2 (see 1 fusions); PRDX6 (see 1 fusions); RPA1 (see 1 fusions); FAN1 (see 1 fusions); MCL1 (see 2 fusions); CUL4A (see 4 fusions); MAGED1 (see 1 fusions); HUWE1 (see 2 fusions); RBBP8 (see 1 fusions); LDHA/SKI (see 3 fusions); USP1 (see 1 fusions); CALR (see 6 fusions); REV1 (see 1 fusions); POLR2A (see 2 fusions); DDB1 (see 2 fusions); GAPDH (see 2 fusions); MME (see 1 fusions); TRIM25 (see 2 fusions); L3MBTL1 (see 1 fusions); CUL7 (see 2 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); KDM5C (see 1 fusions); GAPDH/CDKN1A (see 1 fusions); MDH2 (see 1 fusions); SKI (see 1 fusions); PARP1 (see 1 fusions); CCND1 (see 1 fusions); TP53 (see 3 fusions); MCM7 (see 2 fusions); CREBBP (see 5 fusions); EGFR (see 2 fusions); USP10 (see 1 fusions); KAT5 (see 3 fusions); PFKM (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	PCNA	parental protein	274	0.050	50200.197	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
2	ABL1	oncoprotein	18	0.419	27.169	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ACOT1	interactor	2	1.000	0	BAAT_C (PF08840, IPR014940): BAAT / Acyl-CoA thioester hydrolase C terminal Bile_Hydr_Trans (PF04775, IPR006862): Acyl-CoA thioester hydrolase/BAAT N-terminal region
4	AICDA	interactor	8	0.429	4.766	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
5	AIRE	interactor	12	0.436	7.829	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
6	AKR7A2	interactor	7	0.400	4.471	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7	ALDOA	interactor	20	0.491	27.776	Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8	ANK3	interactor	1	0	0	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain DUF3008 (PF11450, IPR021553): Protein of unknwon function (DUF3008) DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
9	ANXA2	interactor	19	0.333	29.027	Annexin (PF00191, IPR018502, SM00335): Annexin
10	APC	oncoprotein	7	0.400	8.000	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
11	APEX1	interactor	20	0.332	53.811	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
12	APEX2	interactor	1	0	0	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family zf-GRF (PF06839, IPR010666): GRF zinc finger
13	ARHGDIA	interactor	12	0.582	7.900	Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
14	ASB8	interactor	3	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
15	ATAD5	interactor	5	0.500	4.067	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) AAA_16 (PF13191): AAA ATPase domain
16	ATF2	oncoprotein	21	0.284	64.350	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
17	B4GALT7	interactor	1	0	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
18	BABAM1	interactor	2	1.000	0	VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
19	BAZ1B	interactor	7	0.476	7.686	D5_N (PF08706, IPR014818, SM00885): D5 N terminal like DDT (PF02791, IPR004022, SM00571): DDT domain DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PHD (PF00628, IPR019787, SM00249): PHD-finger YL1 (PF05764, IPR008895): YL1 nuclear protein DDRGK (PF09756, IPR019153, SM01128): DDRGK domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3635 (PF12330, IPR024604): Domain of unknown function (DUF3635) Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 FAM176 (PF14851): FAM176 family WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
20	BRCA1	oncoprotein	62	0.165	901.612	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
21	BRCA2	oncoprotein	18	0.294	69.267	BRCA-2_helical (PF09169, IPR015252): BRCA2, helical BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA2 (PF00634, IPR002093): BRCA2 repeat Tower (PF09121, IPR015205): Tower
22	CA2	interactor	6	0.733	0.629	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
23	CALR	oncoprotein	19	0.477	22.312	Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain
24	CALU	interactor	13	0.474	16.191	EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
25	CBX1	interactor	10	0.500	5.721	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
26	CCAR1	oncoprotein	6	0.533	1.364	Cucumo_2B (PF03263, IPR004946): Cucumovirus protein 2B DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) IncA (PF04156, IPR007285): IncA protein Presenilin (PF01080, IPR001108): Presenilin SAP (PF02037, IPR003034, SM00513): SAP domain FimP (PF09766, IPR019163): Fms-interacting protein DBC1 (PF14443, IPR025954, SM01122): DBC1 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) S1-like (PF14444, IPR025223): S1-like DUF4481 (PF14800, IPR028054): Domain of unknown function (DUF4481) FAM176 (PF14851): FAM176 family
27	CCL2	interactor	5	0.833	0.286	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
28	CCNA2	oncoprotein	22	0.376	53.755	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
29	CCNB1	oncoprotein	26	0.237	133.729	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
30	CCND1	oncoprotein	20	0.386	44.960	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
31	CCND3	oncoprotein	9	0.472	7.363	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
32	CCNE1	oncoprotein	15	0.390	20.461	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
33	CCNE2	interactor	4	0.833	0.333	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
34	CCNO	interactor	2	1.000	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
35	CDC20	oncoprotein	18	0.375	40.628	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
36	CDC25C	oncoprotein	6	0.600	1.498	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
37	CDC27	oncoprotein	11	0.422	12.028	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat
38	CDC45	interactor	16	0.283	43.384	CDC45 (PF02724, IPR003874): CDC45-like protein
39	CDC6	oncoprotein	14	0.462	22.145	Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain AAA_22 (PF13401, IPR003593): AAA domain ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
40	CDK2	oncoprotein	72	0.154	1232.459	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
41	CDK4	oncoprotein	19	0.339	49.896	Pkinase (PF00069, IPR000719): Protein kinase domain
42	CDK5	oncoprotein	13	0.333	24.253	Pkinase (PF00069, IPR000719): Protein kinase domain
43	CDKN1A	oncoprotein	37	0.246	273.377	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
44	CDKN1C	oncoprotein	6	0.600	2.319	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family TonB_N (PF16031): TonB N-terminal region
45	CDKN2A	oncoprotein	21	0.305	66.669	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
46	CDT1	oncoprotein	18	0.359	46.453	CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
47	CHAF1A	interactor	17	0.358	48.433	CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A CAF1-p150_C2 (PF15539, IPR029105): CAF1 complex subunit p150, region binding to CAF1-p60 at C-term CAF1-p150_N (PF15557, IPR029091): CAF1 complex subunit p150, region binding to PCNA
48	CHAF1B	interactor	6	0.600	3.117	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain CAF-1_p60_C (PF15512, IPR029129): Chromatin assembly factor complex 1 subunit p60, C-terminal
49	CHEK1	suppressor	23	0.292	98.019	Pkinase (PF00069, IPR000719): Protein kinase domain
50	CHFR	oncoprotein	8	0.381	6.467	FHA (PF00498, IPR000253, SM00240): FHA domain Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92 zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) LAX (PF15681, IPR031393): Lymphocyte activation family X
51	CHTF18	interactor	13	0.667	13.915	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein AAA_19 (PF13245): Part of AAA domain
52	CLSPN	interactor	8	0.500	8.441	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
53	CREBBP	oncoprotein	33	0.288	179.278	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
54	CUL1	oncoprotein	47	0.255	351.819	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
55	CUL2	suppressor	25	0.390	63.628	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
56	CUL3	protein found in more fusions	56	0.201	667.540	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
57	CUL4A	protein found in more fusions	25	0.424	55.390	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
58	CUL4B	oncoprotein	33	0.331	140.734	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
59	CUL5	suppressor	27	0.399	93.010	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
60	CUL7	protein found in more fusions	49	0.226	320.944	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
61	CYFIP1	interactor	4	0.500	1.500	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
62	DCLRE1A	interactor	1	0	0	DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase Glyco_hydro_45 (PF02015, IPR000334): Glycosyl hydrolase family 45 Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
63	DCTPP1	interactor	7	0.533	3.633	MazG-like (PF12643, IPR025984): MazG-like family
64	DDB1	protein found in more fusions	38	0.272	206.109	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
65	DDX11	interactor	4	0.667	1.400	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DEAD_2 (PF06733, IPR010614): DEAD_2 HBB (PF06777, IPR010643): Helical and beta-bridge domain Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
66	DHX15	interactor	21	0.457	18.914	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
67	DHX9	oncoprotein	36	0.360	114.192	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
68	DMAP1	interactor	8	0.536	6.083	DMAP1 (PF05499, IPR008468): DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like (PF16282, IPR032563): SANT/Myb-like domain of DAMP1
69	DNMT1	oncoprotein	19	0.353	50.670	BAH (PF01426, IPR001025, SM00439): BAH domain DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
70	DNTT	interactor	3	0.667	0.154	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
71	DSN1	interactor	4	0.500	1.733	MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
72	DTL	interactor	19	0.298	80.969	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
73	E2F3	oncoprotein	6	0.467	2.237	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
74	EEA1	interactor	3	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like Filament (PF00038, IPR001664): Intermediate filament protein FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger IncA (PF04156, IPR007285): IncA protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
75	EEF1A1	oncoprotein	44	0.256	311.049	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
76	EGFR	oncoprotein	37	0.279	231.021	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
77	ELMO3	interactor	2	1.000	0	ELMO_CED12 (PF04727, IPR006816): ELMO/CED-12 family DnaB_bind (PF10410, IPR019475): DnaB-helicase binding domain of primase DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) PH_12 (PF16457, IPR001849): Pleckstrin homology domain
78	ELP3	interactor	5	0.600	2.500	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family Radical_SAM (PF04055, IPR007197): Radical SAM superfamily Radical_SAM_C (PF16199, IPR032432): Radical_SAM C-terminal domain
79	ENO1	oncoprotein	33	0.369	107.540	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
80	EP300	oncoprotein	45	0.234	371.729	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
81	ERCC5	oncoprotein	6	0.467	3.438	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain IZUMO (PF15005, IPR029389): Izumo sperm-egg fusion, Ig domain-associated Codanin-1_C (PF15296, IPR028171): Codanin-1 C-terminus EF-G-binding_N (PF07299): Elongation factor G-binding protein, N-terminal
82	ERCC6	oncoprotein	16	0.467	27.372	Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
83	ERCC8	oncoprotein	12	0.621	5.610	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
84	EWSR1	oncoprotein	54	0.247	498.094	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
85	EXO1	interactor	6	0.733	2.067	XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
86	FAM13A	interactor	1	0	0	DUF573 (PF04504, IPR007592): Protein of unknown function, DUF573 RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DBP (PF12361, IPR021015): Duffy-antigen binding protein Helo_like_N (PF17111, IPR031348): Fungal N-terminal domain of STAND proteins
87	FAN1	protein found in more fusions	9	0.357	13.067	VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TPR_12 (PF13424): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
88	FANCA	oncoprotein	11	0.311	18.882	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
89	FANCD2	oncoprotein	18	0.275	74.096	FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
90	FANCE	oncoprotein	6	0.500	2.067	FA_FANCE (PF11510, IPR021025): Fanconi Anaemia group E protein FANCE DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
91	FANCL	protein found in more fusions	4	0.667	0.333	WD-3 (PF09765, IPR019162): WD-repeat region FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
92	FBXO18	interactor	7	0.667	2.288	F-box-like (PF12937, IPR001810): F-box-like AAA_19 (PF13245): Part of AAA domain UvrD_C (PF13361, IPR014017): UvrD-like helicase C-terminal domain AAA_30 (PF13604): AAA domain
93	FBXO6	interactor	25	0.277	77.896	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
94	FEN1	oncoprotein	17	0.287	51.709	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
95	FIBP	interactor	2	1.000	0	FIBP (PF05427, IPR008614): Acidic fibroblast growth factor binding (FIBP)
96	FN1	oncoprotein	37	0.212	206.402	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
97	FOXO3	oncoprotein	10	0.467	9.651	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
98	FUS	oncoprotein	34	0.398	109.630	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
99	GADD45A	oncoprotein	11	0.600	6.885	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
100	GADD45G	oncoprotein	6	0.667	1.339	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
101	GAPDH	oncoprotein	38	0.345	143.929	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
102	GCK	interactor	1	0	0	Hexokinase_1 (PF00349, IPR022672): Hexokinase Hexokinase_2 (PF03727, IPR022673): Hexokinase
103	GNPDA1	interactor	7	0.619	3.533	Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
104	GOLGA1	interactor	1	0	0	GRIP (PF01465, IPR000237, SM00755): GRIP domain Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
105	GPI	interactor	12	0.606	5.626	PGI (PF00342, IPR001672): Phosphoglucose isomerase
106	H2AFV	interactor	11	0.400	19.799	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
107	HDAC1	suppressor	41	0.203	370.549	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
108	HDAC5	protein found in more fusions	27	0.243	62.970	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
109	HDAC6	oncoprotein	21	0.221	81.193	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
110	HERC4	interactor	9	0.536	6.956	RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
111	HEXA	interactor	9	0.333	19.567	Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
112	HIST1H3E	interactor	16	0.308	35.096	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
113	HIST2H3C	interactor	14	0.242	41.510	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
114	HK1	interactor	11	0.327	22.465	Hexokinase_1 (PF00349, IPR022672): Hexokinase Hexokinase_2 (PF03727, IPR022673): Hexokinase
115	HLTF	oncoprotein	14	0.397	23.962	HIRAN (PF08797, IPR014905, SM00910): HIRAN domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
116	HSP90B1	oncoprotein	26	0.345	63.230	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
117	HUS1	oncoprotein	9	0.694	2.451	Hus1 (PF04005, IPR007150): Hus1-like protein
118	HUWE1	oncoprotein	41	0.205	324.579	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
119	ING1	suppressor	9	0.500	8.256	PHD (PF00628, IPR019787, SM00249): PHD-finger NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
120	ING2	oncoprotein	4	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger S1FA (PF04689, IPR006779): DNA binding protein S1FA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
121	ITCH	interactor	12	0.382	13.904	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
122	KAT5	oncoprotein	22	0.352	62.313	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
123	KCTD10	interactor	4	1.000	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain
124	KCTD13	interactor	7	0.600	5.067	BTB_2 (PF02214, IPR003131): BTB/POZ domain
125	KDM5C	oncoprotein	4	0.667	1.000	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase JmjN (PF02375, IPR003349, SM00545): jmjN domain PHD (PF00628, IPR019787, SM00249): PHD-finger PLU-1 (PF08429, IPR013637): PLU-1-like protein FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
126	KIAA0101	interactor	4	0.667	0.650	PAF (PF15715, IPR031444): PCNA-associated factor
127	KIAA1522	interactor	1	0	0	OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain NHS (PF15273, IPR024845): NHS-like
128	KIN	interactor	4	0.667	0.750	KOW (PF00467, IPR005824, SM00739): KOW motif SecM (PF06558, IPR009502): Secretion monitor precursor protein (SecM) Kin17_mid (PF10357, IPR019447): Domain of Kin17 curved DNA-binding protein zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
129	KMT5A	interactor	6	0.600	3.067	ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain ERp29 (PF07749, IPR011679): Endoplasmic reticulum protein ERp29, C-terminal domain SET (PF00856, IPR001214, SM00317): SET domain
130	KRT7	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
131	L3MBTL1	protein found in more fusions	7	0.600	3.389	MBT (PF02820, IPR004092, SM00561): mbt repeat zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
132	LAMP2	protein found in more fusions	7	0.333	4.088	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
133	LDHA	protein found in more fusions	25	0.388	50.013	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
134	LIG1	interactor	5	0.700	1.133	DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Presenilin (PF01080, IPR001108): Presenilin
135	MAGED1	protein found in more fusions	8	0.381	5.432	MAGE (PF01454, IPR002190): MAGE family
136	MAPK15	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
137	MBD1	interactor	3	1.000	0	MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
138	MCL1	oncoprotein	6	0.600	1.000	Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
139	MCM4	interactor	17	0.333	37.372	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
140	MCM7	protein found in more fusions	28	0.197	163.254	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
141	MDH2	protein found in more fusions	15	0.330	15.467	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
142	MDM2	oncoprotein	46	0.181	469.598	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
143	MGMT	interactor	15	0.400	21.836	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
144	MLH1	oncoprotein	19	0.357	58.572	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
145	MME	oncoprotein	6	0.500	2.909	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
146	MRPL4	interactor	2	1.000	0	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
147	MRPS25	interactor	3	0.667	0.667	L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
148	MSH2	oncoprotein	40	0.255	287.837	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III AAA_27 (PF13514): AAA domain
149	MSH3	oncoprotein	15	0.505	17.880	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III
150	MSH6	oncoprotein	32	0.268	182.496	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II PWWP (PF00855, IPR000313, SM00293): PWWP domain MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III UPF0524 (PF15823, IPR029670): UPF0524 of C3orf70
151	MUTYH	oncoprotein	6	0.533	1.524	HhH-GPD (PF00730, IPR003265): HhH-GPD superfamily base excision DNA repair protein EndIII_4Fe-2S (PF10576, IPR003651): Iron-sulfur binding domain of endonuclease III NUDIX_4 (PF14815, IPR029119): NUDIX domain
152	MYBBP1A	oncoprotein	12	0.409	17.546	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
153	NACA2	interactor	5	0.900	0.333	NAC (PF01849, IPR002715): NAC domain
154	NOS1AP	interactor	1	0	0	Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
155	NTRK1	oncoprotein	101	0.121	2784.734	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
156	OBSCN	oncoprotein	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain TOBE_2 (PF08402, IPR013611): TOBE domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
157	OBSL1	interactor	42	0.216	243.067	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
158	OTUB1	interactor	10	0.422	11.783	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
159	P4HB	interactor	22	0.414	43.530	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
160	PABPN1	interactor	9	0.889	0.591	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
161	PACSIN3	interactor	3	1.000	0	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain GrpE (PF01025, IPR000740): GrpE SH3_9 (PF14604, IPR001452): Variant SH3 domain
162	PARK2	suppressor	27	0.188	117.963	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
163	PARP1	suppressor	38	0.320	175.777	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
164	PARP10	interactor	2	1.000	0	PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
165	PDCD10	interactor	6	0.467	6.000	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
166	PDS5B	oncoprotein	8	0.429	7.933	AT_hook (PF02178, IPR017956, SM00384): AT hook motif HEAT (PF02985, IPR000357): HEAT repeat Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain DUF3665 (PF12427, IPR024614): Branched-chain amino acid aminotransferase Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2 PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
167	PFKM	protein found in more fusions	9	0.607	4.328	PFK (PF00365, IPR000023): Phosphofructokinase
168	PGAM1	interactor	8	0.607	5.014	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
169	PGK1	interactor	19	0.485	27.710	PGK (PF00162, IPR001576): Phosphoglycerate kinase
170	PIDD1	interactor	8	0.286	7.561	Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Peptidase_S68 (PF10461, IPR019502): Peptidase S68 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
171	PKLR	interactor	1	0	0	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
172	PLAA	interactor	6	0.733	2.167	PFU (PF09070, IPR015155): PFU (PLAA family ubiquitin binding) PUL (PF08324, IPR013535): PUL domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
173	PMS2	oncoprotein	15	0.381	29.922	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
174	POLA1	interactor	19	0.339	54.005	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-DNA_Pol (PF08996, IPR015088): DNA Polymerase alpha zinc finger DNA_pol_alpha_N (PF12254, IPR024647): DNA polymerase alpha subunit p180 N terminal
175	POLB	interactor	8	0.464	4.982	DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda HHH_2 (PF12826): Helix-hairpin-helix motif HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm
176	POLD1	interactor	22	0.290	104.439	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
177	POLD2	interactor	8	0.536	8.333	DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
178	POLD3	interactor	10	0.444	16.674	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
179	POLD4	interactor	7	0.571	8.000	DNA_pol_delta_4 (PF04081, IPR007218): DNA polymerase delta, subunit 4
180	POLDIP2	interactor	7	0.429	7.300	DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525) YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
181	POLE	interactor	5	0.600	2.667	DNA_pol_B (PF00136, IPR006134): DNA polymerase family B DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain DUF1744 (PF08490, IPR013697, SM01159): Domain of unknown function (DUF1744) DNA_pol_B_exo2 (PF10108, IPR019288): Predicted 3'-5' exonuclease related to the exonuclease domain of PolB zf-RRPl_C4 (PF17026, IPR031502): Putative ribonucleoprotein zinc-finger pf C4 type
182	POLH	oncoprotein	14	0.308	47.391	IMS (PF00817, IPR001126): impB/mucB/samB family IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
183	POLI	interactor	4	0.667	1.500	IMS (PF00817, IPR001126): impB/mucB/samB family Cdd1 (PF11731, IPR021725): Pathogenicity locus IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
184	POLK	interactor	12	0.364	22.037	ATP-cone (PF03477, IPR005144): ATP cone domain IMS (PF00817, IPR001126): impB/mucB/samB family IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
185	POLL	interactor	4	0.667	0.591	HHH (PF00633, IPR000445): Helix-hairpin-helix motif DNA_pol_lambd_f (PF10391, IPR018944): Fingers domain of DNA polymerase lambda HHH_5 (PF14520): Helix-hairpin-helix domain HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain DNA_pol_B_thumb (PF14791, IPR029398): DNA polymerase beta thumb DNA_pol_B_palm (PF14792, IPR028207): DNA polymerase beta palm BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
186	POLN	interactor	6	0.533	4.733	DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
187	POLR2A	protein found in more fusions	28	0.359	90.366	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
188	POM121C	interactor	2	1.000	0	T2SSC (PF11356): Type II secretion system protein C Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region POM121 (PF15229): POM121 family
189	PPIA	interactor	19	0.497	26.785	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
190	PPIB	interactor	15	0.505	18.956	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
191	PPME1	protein found in more fusions	12	0.436	11.764	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
192	PPP1CC	oncoprotein	16	0.325	41.847	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
193	PRDX3	interactor	13	0.364	8.383	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
194	PRDX6	protein found in more fusions	12	0.473	6.072	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
195	PRKDC	protein found in more fusions	45	0.254	310.834	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
196	PTMA	oncoprotein	8	0.536	4.002	Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
197	PUS1	interactor	3	1.000	0	PseudoU_synth_1 (PF01416, IPR020097): tRNA pseudouridine synthase
198	RAD18	interactor	19	0.242	84.721	PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47 SAP (PF02037, IPR003034, SM00513): SAP domain zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
199	RAD21	oncoprotein	25	0.323	93.578	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
200	RAD23A	oncoprotein	20	0.287	75.540	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
201	RAD51	interactor	22	0.300	85.222	Rad51 (PF08423, IPR013632): Rad51 HHH_5 (PF14520): Helix-hairpin-helix domain
202	RAD9A	oncoprotein	13	0.397	24.246	Rad9 (PF04139, IPR007268): Rad9
203	RBBP6	oncoprotein	6	0.800	0.409	DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936) DWNN (PF08783, IPR014891): DWNN domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region U-box (PF04564, IPR003613, SM00504): U-box domain SBF2 (PF12335, IPR022096): Myotubularin protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 PRIMA1 (PF16101): Proline-rich membrane anchor 1
204	RBBP8	oncoprotein	9	0.357	9.189	ZapB (PF06005, IPR009252): Cell division protein ZapB Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
205	RBM7	interactor	4	0.500	2.080	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
206	RECQL5	oncoprotein	9	0.500	8.356	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component
207	REV1	protein found in more fusions	12	0.382	22.291	IMS (PF00817, IPR001126): impB/mucB/samB family Cdd1 (PF11731, IPR021725): Pathogenicity locus IMS_HHH (PF11798, IPR024728): IMS family HHH motif IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain REV1_C (PF16727, IPR031991): DNA repair protein REV1 C-terminal domain
208	RFC1	interactor	23	0.411	64.815	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family Nexin_C (PF08628, IPR013937): Sorting nexin C terminal RFC1 (PF08519, IPR013725): Replication factor RFC1 C terminal domain DUF2316 (PF10078, IPR018757): Uncharacterized protein conserved in bacteria (DUF2316)
209	RFC2	interactor	16	0.517	28.335	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_16 (PF13191): AAA ATPase domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
210	RFC3	interactor	16	0.600	16.200	CHB_HEX (PF03173, IPR004866, SM01081): Putative carbohydrate binding domain DNA_pol3_delta (PF06144, IPR010372): DNA polymerase III, delta subunit Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain DNA_pol3_delta2 (PF13177): DNA polymerase III, delta subunit
211	RFC4	interactor	22	0.446	57.951	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
212	RFC5	interactor	18	0.588	19.288	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
213	RNF20	interactor	9	0.393	13.776	Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein Atrophin-1 (PF03154, IPR002951): Atrophin-1 family BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Sox_N (PF12444, IPR022151): Sox developmental protein N terminal DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
214	RNF8	suppressor	9	0.286	12.674	FHA (PF00498, IPR000253, SM00240): FHA domain Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
215	RPA1	suppressor	68	0.205	918.922	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
216	RPA2	oncoprotein	50	0.244	375.184	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
217	RPA3	interactor	42	0.274	187.723	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
218	RPS6KB2	interactor	15	0.324	23.107	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
219	RPSA	interactor	16	0.400	28.194	Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2 40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
220	RUVBL2	oncoprotein	35	0.251	174.172	TIP49 (PF06068, IPR010339): TIP49 C-terminus
221	RYK	oncoprotein	5	0.700	2.000	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
222	SEC22A	interactor	1	0	0	Longin (PF13774, IPR010908): Regulated-SNARE-like domain
223	SETDB1	interactor	9	0.333	19.019	MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537) PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
224	SETMAR	interactor	4	0.667	0.333	Pre-SET (PF05033, IPR007728): Pre-SET motif SET (PF00856, IPR001214, SM00317): SET domain Transposase_1 (PF01359, IPR001888): Transposase (partial DDE domain) HTH_Tnp_Tc3_2 (PF01498, IPR002492): Transposase DDE_3 (PF13358): DDE superfamily endonuclease HTH_32 (PF13565): Homeodomain-like domain
225	SGTA	interactor	5	0.500	2.915	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_17 (PF13431): Tetratricopeptide repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
226	SHPRH	suppressor	5	0.900	0.333	SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
227	SIVA1	interactor	5	0.700	1.071	Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
228	SKI	oncoprotein	5	0.667	0.333	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
229	SLC27A4	interactor	3	1.000	0	AMP-binding (PF00501, IPR000873): AMP-binding enzyme AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
230	SLX4	suppressor	7	0.619	2.215	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Slx4 (PF09494, IPR018574): Slx4 endonuclease zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
231	SMARCAD1	interactor	19	0.386	40.439	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
232	SNU13	interactor	9	0.571	2.246	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
233	SPAG1	interactor	1	0	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597) TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 TPR_19 (PF14559): Tetratricopeptide repeat
234	SPRTN	interactor	17	0.257	65.423	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
235	STK39	interactor	3	1.000	0	BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein) FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) Pkinase (PF00069, IPR000719): Protein kinase domain OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
236	TDG	interactor	5	0.800	0.536	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
237	TFAP4	oncoprotein	8	0.607	2.055	DivIC (PF04977, IPR007060): Septum formation initiator HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
238	TIMELESS	interactor	6	0.533	4.900	Myc_N (PF01056, IPR012682): Myc amino-terminal region TIMELESS (PF04821, IPR006906): Timeless protein TIMELESS_C (PF05029, IPR007725): Timeless protein C terminal region Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
239	TIRAP	interactor	2	0	0	TIR_2 (PF13676, IPR000157): TIR domain
240	TMEM218	interactor	1	0	0	Gram_pos_anchor (PF00746, IPR019948): Gram positive anchor
241	TNFAIP1	oncoprotein	5	1.000	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain
242	TOP1	oncoprotein	19	0.404	29.445	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
243	TP53	oncoprotein	84	0.142	1821.817	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
244	TPI1	interactor	20	0.468	33.339	TIM (PF00121, IPR000652): Triosephosphate isomerase
245	TRAIP	interactor	7	0.333	5.733	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein ORF6C (PF10552, IPR018878): ORF6C domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
246	TRIM25	protein found in more fusions	10	0.361	16.067	Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
247	U2AF2	protein found in more fusions	35	0.323	130.166	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
248	UBE2A	interactor	14	0.372	28.345	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
249	UBE2B	interactor	8	0.667	3.571	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
250	UBE2D3	interactor	17	0.175	69.441	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
251	UHRF1	interactor	14	0.423	23.322	PHD (PF00628, IPR019787, SM00249): PHD-finger SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1 zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
252	UHRF1BP1	interactor	2	1.000	0	Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13 VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
253	UHRF2	oncoprotein	19	0.340	41.830	PHD (PF00628, IPR019787, SM00249): PHD-finger SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1 zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
254	UNG	interactor	6	0.733	1.352	UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily
255	USP1	protein found in more fusions	8	0.429	7.956	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
256	USP10	protein found in more fusions	7	0.600	1.587	PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase YukD (PF08817, IPR024962): WXG100 protein secretion system (Wss), protein YukD
257	USP18	interactor	1	0	0	TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
258	USP2	interactor	7	0.429	6.547	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
259	USP39	oncoprotein	9	0.556	3.490	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
260	USP4	oncoprotein	9	0.464	8.275	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
261	USP5	interactor	11	0.345	27.539	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
262	UTY	interactor	1	0	0	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase Nnf1 (PF03980, IPR007128): Nnf1 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
263	WARS	interactor	11	0.418	19.541	tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
264	WDR48	suppressor	11	0.400	16.698	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
265	WHSC1	oncoprotein	6	0.400	3.002	PHD (PF00628, IPR019787, SM00249): PHD-finger PWWP (PF00855, IPR000313, SM00293): PWWP domain REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein) SET (PF00856, IPR001214, SM00317): SET domain HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
266	WRN	oncoprotein	21	0.400	48.618	DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease DEAD (PF00270, IPR011545): DEAD/DEAH box helicase HRDC (PF00570, IPR002121, SM00341): HRDC domain Laminin_II (PF06009, IPR010307): Laminin Domain II RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HTH_40 (PF14493, IPR029491): Helix-turn-helix domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
267	WRNIP1	interactor	9	0.393	9.776	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
268	XPNPEP1	interactor	11	0.291	31.133	Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
269	XRCC1	interactor	14	0.451	28.174	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain SPX (PF03105, IPR004331): SPX domain XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
270	XRCC5	suppressor	40	0.308	196.349	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
271	XRCC6	oncoprotein	42	0.298	226.191	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
272	YBX1	oncoprotein	25	0.347	69.260	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
273	ZBTB1	interactor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
274	ZRANB3	interactor	2	1.000	0	HNH (PF01844, IPR002711): HNH endonuclease SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain zf-HIT (PF04438, IPR007529): HIT zinc finger Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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