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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PBLD (from a repository: Sun Dec 4 15:18:57 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins2 (18.18 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)17 (30.91 %)
The number (and %) of affected PPIs11 (64.71 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.182
Assortativity coefficient-0.4472
The network average Clustering coefficient0.368
The number (and %) of a zero Clustering coefficients6 (54.55 %)
The number (and %) of a zero Betweenness Centrality10 (90.91 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions PBLD (see 1 fusions); STRAP (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PBLDparental protein110.04486.000PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
2 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
3 CCDC184interactor100DUF4677 (PF15726, IPR031458): Domain of unknown function (DUF4677)
4 EFHC2interactor100DUF1126 (PF06565, IPR010554): Repeat of unknown function (DUF1126)
EF-hand_6 (PF13405, IPR002048): EF-hand domain
5 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
6 MATN3interactor21.0000VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Matrilin_ccoil (PF10393, IPR019466): Trimeric coiled-coil oligomerisation domain of matrilin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
7 STRAPprotein found in more fusions200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 TCF4suppressor21.0000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
9 TRIP13interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
10 TRMT61Ainteractor100GCD14 (PF08704, IPR014816): tRNA methyltransferase complex GCD14 subunit
GCD14_N (PF14801): tRNA methyltransferase complex GCD14 subunit N-term
11 ZRANB1interactor100Copper-fist (PF00649, IPR001083, SM01090): Copper fist DNA binding domain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others

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