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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins29 (42.03 %)
The number (and %) of the tumor suppressors6 (8.70 %)
Total number of binary PPIs (saturation %)252 (10.74 %)
The number (and %) of affected PPIs69 (27.38 %)
The number of possible different fusions15
PPI diameter2
PPI radius1
The average degree of PPI6.261
Assortativity coefficient-0.3287
The network average Clustering coefficient0.518
The number (and %) of a zero Clustering coefficients14 (20.29 %)
The number (and %) of a zero Betweenness Centrality29 (42.03 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PAK1 All fusions
Proteins found in more fusions APP (see 4 fusions); PAK2 (see 2 fusions); RAC1 (see 1 fusions); TGM2 (see 4 fusions); YWHAG (see 1 fusions); ELF3 (see 2 fusions); MYO6 (see 3 fusions); SH3KBP1 (see 1 fusions); HSP90AA1 (see 3 fusions); MAP3K1 (see 1 fusions); LYN (see 2 fusions); YWHAZ (see 1 fusions); LIMK1 (see 1 fusions); EGFR (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PAK1parental protein690.0653602.605PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
2 ABI3interactor41.0000Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
SH3_9 (PF14604, IPR001452): Variant SH3 domain
3 AKT1oncoprotein130.43927.138PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 APPprotein found in more fusions160.34350.438APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ARHGEF2oncoprotein70.4298.186IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 ARHGEF6oncoprotein100.47215.633CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
7 ARHGEF7interactor80.6434.633Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
8 ARPC1Binteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
9 BADoncoprotein60.8001.400Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
10 BAIAP2interactor80.4295.986IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
11 BMXinteractor50.9000.400BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_8 (PF15409): Pleckstrin homology domain
12 BRSK1suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
13 C5orf42interactor100Joubert (PF15392, IPR028236): Joubert syndrome-associated
14 CDC42oncoprotein90.46410.400Ras (PF00071, IPR001806, SM00173): Ras family
15 CDK11Aoncoprotein21.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
16 CDK5oncoprotein51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 CHORDC1interactor31.0000CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
18 CRIPAKinteractor21.0000AnfO_nitrog (PF09582, IPR014287): Iron only nitrogenase protein AnfO (AnfO_nitrog)
Phage_Coat_B (PF05356, IPR008020): Phage Coat protein B
SEC-C (PF02810, IPR004027): SEC-C motif
zf-HIT (PF04438, IPR007529): HIT zinc finger
KAAG1 (PF15354, IPR029407): Kidney-associated antigen 1
19 DYNLL1interactor40.6671.000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
20 DYNLL2interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
21 DYRK1Boncoprotein50.5002.667Pkinase (PF00069, IPR000719): Protein kinase domain
22 EGFRoncoprotein210.279103.186Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23 ELF3oncoprotein40.6670.667AT_hook (PF02178, IPR017956, SM00384): AT hook motif
Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
24 ERBB2oncoprotein100.44414.567Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
25 ESR1suppressor110.37825.300Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
26 FBXO28interactor40.6671.333Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
F-box (PF00646, IPR001810, SM00256): F-box domain
FAM76 (PF16046, IPR032017): FAM76 protein
27 GIT1interactor90.6077.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
28 GIT2interactor51.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Sen15 (PF09631, IPR018593): Sen15 protein
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
29 GNB1interactor31.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
30 H2AFXsuppressor70.6196.119Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
31 HGSinteractor60.4675.733FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
32 HIST1H3Ainteractor70.6004.233Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
33 HIST1H4Ainteractor41.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
34 HSP90AA1oncoprotein200.234110.167HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
35 ILKAPinteractor30.6670.500PP2C (PF00481, IPR001932): Protein phosphatase 2C
36 LIMK1oncoprotein60.7001.186LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
37 LYNoncoprotein70.5335.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
38 MAP3K1oncoprotein60.5003.833zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
39 MYLKinteractor100Amelogenin (PF02948, IPR004116, SM00818): Amelogenin
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
40 MYNNinteractor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
41 MYO6protein found in more fusions50.6672.000BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
42 NCK1oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
43 NCK2interactor120.40024.567SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
44 PAK1IP1interactor100eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
45 PAK2protein found in more fusions190.216106.433PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
46 PKLRinteractor21.0000PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
47 PLCG1oncoprotein60.5334.300C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
48 PPATinteractor100Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
49 PYCARDsuppressor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
50 RAC1oncoprotein90.42910.233Ras (PF00071, IPR001806, SM00173): Ras family
51 RAF1oncoprotein100.5569.238Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
52 RELAoncoprotein40.6670.667DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
53 RHOJinteractor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
54 RHOUinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
55 SH3KBP1protein found in more fusions90.39310.233Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
56 SLC25A41interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
57 SNW1protein found in more fusions40.6670.667SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
58 SORBS3interactor40.6670.400Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
59 TAS2R41interactor100TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
60 TGFBR1oncoprotein60.6672.833Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
61 TGFBR2suppressor80.5008.800ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
62 TGM2protein found in more fusions61.0000Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
63 YWHAGprotein found in more fusions130.42424.20014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
64 YWHAZprotein found in more fusions150.41835.11914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
65 ZBTB18suppressor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
zinc_ribbon_15 (PF17032, IPR031493): zinc-ribbon family
66 ZC3H7Ainteractor100SapA (PF02199, IPR003119, SM00162): Saposin A-type domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
67 ZNF418interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Fer4_10 (PF13237, IPR017896): 4Fe-4S dicluster domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
68 ZNF823interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
69 ZNF83interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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