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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PAG1 (from a repository: Fri Nov 11 23:12:38 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins8 (44.44 %)
The number (and %) of the tumor suppressors3 (16.67 %)
Total number of binary PPIs (saturation %)69 (45.10 %)
The number (and %) of affected PPIs18 (26.09 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI6.556
Assortativity coefficient-0.3007
The network average Clustering coefficient0.571
The number (and %) of a zero Clustering coefficients2 (11.11 %)
The number (and %) of a zero Betweenness Centrality2 (11.11 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PAG1 All fusions
: AW401639;
Proteins found in more fusions LCK (see 1 fusions); PAG1 (see 1 fusions); FYN (see 1 fusions); SHC1 (see 1 fusions); LYN (see 1 fusions); SYK (see 1 fusions); GRB2 (see 1 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PAG1parental protein180.309118.886PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched
2 ABL1oncoprotein70.8670.733Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 CCR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 CSKinteractor50.8001.067Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 FYNoncoprotein90.35714.452Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
6 GRB2oncoprotein100.6945.186SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
7 HOXB5interactor30.6670.400DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
8 LCKoncoprotein50.8330.286Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 LCP2interactor80.7502.919SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SDA1 (PF05285, IPR007949): SDA1
SH2 (PF00017, IPR000980, SM00252): SH2 domain
10 LYNoncoprotein90.39313.833Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 PTPN6suppressor90.6676.019SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
12 SHC1oncoprotein80.6673.900PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
13 SLC25A41interactor30.6670.400Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
14 SLC9A3R1suppressor200EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
15 SYKsuppressor90.6075.533Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 TMEM185Ainteractor30.6670.400Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
17 VAV1oncoprotein80.7503.186PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
18 ZAP70interactor110.57810.800Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain

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