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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PACSIN2 (from a repository: Sat Nov 12 09:37:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins11 (23.91 %)
The number (and %) of the tumor suppressors4 (8.70 %)
Total number of binary PPIs (saturation %)134 (12.95 %)
The number (and %) of affected PPIs46 (34.33 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.087
Assortativity coefficient-0.5043
The network average Clustering coefficient0.669
The number (and %) of a zero Clustering coefficients6 (13.04 %)
The number (and %) of a zero Betweenness Centrality24 (52.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PACSIN2 All fusions
Proteins found in more fusions UGP2 (see 1 fusions); FTL (see 3 fusions); TERF2IP (see 1 fusions); EWSR1 (see 2 fusions); PLOD2 (see 1 fusions); KHDRBS1 (see 1 fusions); PACSIN2 (see 1 fusions); HSPA8/HSPD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PACSIN2parental protein460.0731543.800DegS (PF05384, IPR008595): Sensor protein DegS
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3BP5 (PF05276, IPR007940): SH3 domain-binding protein 5 (SH3BP5)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
2 ANKS1Ainteractor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
3 APBB1IPinteractor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
MLANA (PF14991, IPR029242): Protein melan-A
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
4 ASAP1interactor31.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
BAR_3 (PF16746): BAR domain of APPL family
5 CARSoncoprotein31.0000tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
6 COBLinteractor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Cobl (PF09469, IPR019025): Cordon-bleu ubiquitin-like domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
7 COBLL1interactor31.0000Cobl (PF09469, IPR019025): Cordon-bleu ubiquitin-like domain
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
8 COL4A3BPinteractor40.6671.000Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
9 CYFIP2interactor31.0000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
10 DNM1interactor51.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
11 DNM2interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
12 ERP44interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
13 EWSR1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
14 FASLGinteractor100PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
15 FTLprotein found in more fusions40.6671.000Ferritin (PF00210, IPR008331): Ferritin-like domain
16 HSPA1Ainteractor70.6674.567HSP70 (PF00012, IPR013126): Hsp70 protein
17 HSPA8oncoprotein60.8001.500HSP70 (PF00012, IPR013126): Hsp70 protein
18 HSPD1suppressor70.42912.000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 KHDRBS1protein found in more fusions60.6003.400KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
20 MEOX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
21 MICALL1interactor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
FAM70 (PF14967, IPR028014): FAM70 protein
22 MOV10interactor21.0000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
23 MPRIPinteractor100Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Fez1 (PF06818): Fez1
FliT (PF05400, IPR008622): Flagellar protein FliT
HalX (PF08663, IPR013971): HalX domain
Mnd1 (PF03962, IPR005647): Mnd1 family
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
YlqD (PF11068, IPR021297): YlqD protein
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
24 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 PACSIN1interactor200.23490.967FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
26 PACSIN3interactor230.195144.400FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
GrpE (PF01025, IPR000740): GrpE
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 PLOD2protein found in more fusions70.5336.6672OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
28 POT1interactor70.5335.500POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
29 PPP2R5Csuppressor40.5002.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
DUF1616 (PF07760, IPR011674): Protein of unknown function (DUF1616)
30 PTGES3interactor31.0000CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
31 PTPN12suppressor50.7003.000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
PTPlike_phytase (PF14566): Inositol hexakisphosphate
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
32 SBK1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
33 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
34 ST13suppressor41.0000Hox9_act (PF04617, IPR006711): Hox9 activation region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
35 SWAP70oncoprotein30.6670.667DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
GrpE (PF01025, IPR000740): GrpE
PH (PF00169, IPR001849, SM00233): PH domain
CotJB (PF12652, IPR024207): CotJB protein
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
36 SYNJ1interactor31.0000DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
YppG (PF14179, IPR025555): YppG-like protein
37 TERF1interactor60.5005.000TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
38 TERF2IPprotein found in more fusions50.6671.400BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
39 THG1Linteractor31.0000Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
40 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
41 UGP2protein found in more fusions60.7002.667UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
42 VASNinteractor41.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TraW_N (PF12477, IPR025864): Sex factor F TraW protein N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
43 WASoncoprotein50.7002.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
44 WASLinteractor50.7002.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
45 WIPF1interactor50.9000.400CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GRP (PF07172, IPR010800): Glycine rich protein family
WH2 (PF02205, IPR003124, SM00246): WH2 motif
46 WIPF2interactor30.6670.400CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
WH2 (PF02205, IPR003124, SM00246): WH2 motif
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins

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