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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OXCT1 (from a repository: Wed Feb 6 19:08:08 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)63
The number (and %) of the onco-proteins11 (17.46 %)
The number (and %) of the tumor suppressors9 (14.29 %)
Total number of binary PPIs (saturation %)237 (12.14 %)
The number (and %) of affected PPIs63 (26.58 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI6.825
Assortativity coefficient-0.2402
The network average Clustering coefficient0.571
The number (and %) of a zero Clustering coefficients2 (3.17 %)
The number (and %) of a zero Betweenness Centrality10 (15.87 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OXCT1 All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); NDUFS3 (see 1 fusions); PTPN11 (see 1 fusions); AHNAK (see 2 fusions); OXCT1 (see 1 fusions); HINT1 (see 3 fusions); PRDX6 (see 1 fusions); MAPK14 (see 1 fusions); NCL (see 3 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OXCT1parental protein630.0812890.356CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
2 ADSSinteractor90.7504.289Adenylsucc_synt (PF00709, IPR001114, SM00788): Adenylosuccinate synthetase
3 AHNAKsuppressor31.0000DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
4 ATIConcoprotein40.6671.333AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
5 C11orf58interactor40.6671.000DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
6 C12orf10interactor60.6003.900UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
7 C1QBPinteractor100.28930.167MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
8 CBX3interactor80.9520.222Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
9 CTTNoncoprotein50.6671.500FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
10 FHsuppressor50.5003.500Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
11 FMC1interactor30.6670.500Complex1_LYR_2 (PF13233): Complex1_LYR-like
12 HINT1suppressor40.6671.000HIT (PF01230, IPR001310): HIT domain
13 HSPB1oncoprotein90.35714.300HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
14 HSPD1suppressor80.39311.700Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
15 IDH1suppressor100.6227.667Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
16 IQCB1interactor80.32112.967DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
17 LYPLA1interactor31.0000Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase
18 MAPK14oncoprotein70.4675.167Pkinase (PF00069, IPR000719): Protein kinase domain
19 MDH1interactor60.5333.400Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
20 MTPNinteractor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
21 NCLprotein found in more fusions31.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
22 NDUFS3protein found in more fusions80.6194.333Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
23 NDUFV1interactor120.24241.833Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
24 NME1suppressor80.5716.789NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
25 NTRK1oncoprotein240.158190.756I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
26 OXCT2interactor31.0000CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
27 PAK5interactor50.6671.000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
28 PGK1interactor50.7001.500PGK (PF00162, IPR001576): Phosphoglycerate kinase
29 PLAURoncoprotein60.4677.667Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
30 PRDX6protein found in more fusions120.27333.800AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
31 PRSS35interactor31.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
32 PSEN1oncoprotein200Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
33 PSME1interactor200PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
34 PTMSinteractor90.7503.789Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
35 PTPMT1interactor60.7001.833DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
36 PTPN11suppressor60.4004.833SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
37 RAE1interactor30.6671.000Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38 RBBP7suppressor80.7503.022WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
39 S100A16interactor90.25022.833S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
40 SCAF4interactor70.38112.667CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
41 SDHAsuppressor100.42220.067FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
42 SDHAF2oncoprotein60.4676.667Sdh5 (PF03937, IPR005631): Flavinator of succinate dehydrogenase
Peroxidase_2 (PF01328, IPR000028): Peroxidase, family 2
Reovirus_cap (PF00979, IPR000153): Reovirus outer capsid protein, Sigma 3
43 SEPT11interactor60.3337.667Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
44 SGSHinteractor40.5003.000Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
45 SOD1interactor40.6671.000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
46 SUCLA2interactor50.7001.733ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
47 SUCLG1interactor50.6003.067CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
CoA_binding_2 (PF13380, IPR003781): CoA binding domain
48 SVILinteractor21.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
49 TALDO1interactor80.8571.356TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
50 TCOF1interactor50.4003.467CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase
Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
51 THOP1interactor130.52622.456Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
52 TIMM9interactor50.5003.500zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
53 TMEM177interactor30.6670.400NA
54 TMEM189interactor50.4004.067MARVEL (PF01284, IPR008253): Membrane-associating domain
TMEM189_B_dmain (PF10520, IPR019547): B domain of TMEM189, localisation domain
55 TMEM9interactor40.5002.400Tmemb_9 (PF05434, IPR008853): TMEM9
56 TOR1AIP1interactor40.5001.400LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Pap_E4 (PF02711, IPR003861): E4 protein
57 TPI1interactor80.4765.900TIM (PF00121, IPR000652): Triosephosphate isomerase
58 UBXN7interactor30.6670.500UBX (PF00789, IPR001012, SM00166): UBX domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
59 UQCRFS1interactor110.34528.567Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
60 UQCRFS1P1interactor21.0000NA
61 VAPBinteractor50.5003.733ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
62 VMA21interactor40.6672.000VMA21 (PF09446, IPR019013): VMA21-like domain
63 WDR1interactor120.48522.433eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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