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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OXA1L (from a repository: Mon Nov 14 12:18:21 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins2 (7.41 %)
The number (and %) of the tumor suppressors2 (7.41 %)
Total number of binary PPIs (saturation %)81 (23.08 %)
The number (and %) of affected PPIs27 (33.33 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.333
Assortativity coefficient-0.4415
The network average Clustering coefficient0.537
The number (and %) of a zero Clustering coefficients4 (14.81 %)
The number (and %) of a zero Betweenness Centrality8 (29.63 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: OXA1L All fusions
: BG763334;
Proteins found in more fusions GAN (see 1 fusions); OXA1L (see 1 fusions); ILK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OXA1Lparental protein270.142458.06760KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
2 ABCC2interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805)
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
3 ATP5Binteractor50.4004.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
4 CBLConcoprotein100Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
5 CHCHD10interactor31.0000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
6 COQ9interactor70.4008.667COQ9 (PF08511, IPR013718): COQ9
7 FAF2interactor40.6670.667DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
8 FRMD3interactor100FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
9 GANprotein found in more fusions200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
10 IKBIPinteractor100Fez1 (PF06818): Fez1
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
11 ILKsuppressor70.3338.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
12 MOV10interactor60.4676.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
13 MRPL13interactor60.8001.667Ribosomal_L13 (PF00572, IPR005822): Ribosomal protein L13
14 MRPL20interactor50.7002.167Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
15 MRPL23interactor80.53612.000Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
16 MRPL28interactor70.7622.400Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
17 MRPL48interactor40.6671.167Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
18 MRPL49interactor60.6004.667Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
19 MRPL50interactor90.5838.567Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
20 MRPL51interactor41.0000MRP-L51 (PF10244, IPR019373): Mitochondrial ribosomal subunit
21 MRPL58interactor110.45521.233RF-1 (PF00472, IPR000352): RF-1 domain
22 NDUFA4interactor50.6671.667B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
23 NXF1interactor40.6670.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 PTPMT1interactor31.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
25 RHOT2interactor30.6670.667EF_assoc_1 (PF08355, IPR013566): EF hand associated
EF_assoc_2 (PF08356, IPR013567): EF hand associated
Ras (PF00071, IPR001806, SM00173): Ras family
SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region
AAA_16 (PF13191): AAA ATPase domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
26 SDHBsuppressor70.38110.833Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
27 TOMM40interactor50.6003.333Porin_3 (PF01459, IPR027246): Eukaryotic porin

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MRPL48interactorRibosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20eBG763334
2 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunitBG763334
3 OXA1Lparental protein60KD_IMP (PF02096, IPR001708): 60Kd inner membrane proteinBG763334

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