Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OSTM1, PROSC (from a repository: Thu Nov 10 14:59:26 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins18 (25.00 %)
The number (and %) of the tumor suppressors1 (1.39 %)
Total number of binary PPIs (saturation %)269 (10.52 %)
The number (and %) of affected PPIs70 (26.02 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI6.972
Assortativity coefficient-0.3026
The network average Clustering coefficient0.436
The number (and %) of a zero Clustering coefficients21 (29.17 %)
The number (and %) of a zero Betweenness Centrality26 (36.11 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OSTM1,PROSC All fusions
: DB502399; DB495307;
Proteins found in more fusions NDUFS3 (see 1 fusions); LGALS3 (see 2 fusions); MCM2 (see 1 fusions); NAGK (see 1 fusions); DDX17 (see 3 fusions); RPA1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OSTM1parental protein120.0151123.861OSTMP1 (PF09777, IPR019172): Osteopetrosis-associated transmembrane protein 1 precursor
2 PROSCparental protein580.0972925.101Ala_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
3 ADI1interactor100ARD (PF03079, IPR004313): ARD/ARD' family
4 AHSA1interactor70.42913.009Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
6 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
7 ASB6interactor50.60024.423Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
8 ASNSoncoprotein140.63726.489Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
9 ATIConcoprotein120.60614.631AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
10 ATP6AP2interactor200Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
11 BIRC7interactor200BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
12 CAPN2interactor170.39763.003Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
13 CAPNS1interactor110.8912.344EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
14 CARSoncoprotein30.6671.067tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
15 CDK5R1oncoprotein100CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
16 CHORDC1interactor70.4676.833CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
17 DDX17protein found in more fusions80.61952.388CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 EIF4Eoncoprotein21.0000IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
19 ELAVL1oncoprotein160.152878.587RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 ENSAinteractor100Endosulfine (PF04667, IPR006760): cAMP-regulated phosphoprotein/endosulfine conserved region
21 FAM177A1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Connexin (PF00029, IPR013092, SM00037): Connexin
FAM177 (PF14774, IPR028260): FAM177 family
22 FCGR2Ainteractor2074.578DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
23 GPSM1interactor200GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_12 (PF13424): Tetratricopeptide repeat
24 GRK2interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
25 GSRinteractor50.50030.478Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
26 GTF3C4interactor41.0000TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
27 HEXBinteractor60.7002.175Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
28 HK1interactor80.500103.377Hexokinase_1 (PF00349, IPR022672): Hexokinase
Hexokinase_2 (PF03727, IPR022673): Hexokinase
29 HNRNPA1interactor150.275220.609RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
30 HNRNPA3oncoprotein60.8670.900IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
31 ISOC1interactor150.64851.420Isochorismatase (PF00857, IPR000868): Isochorismatase family
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
32 LGALS3oncoprotein50.167152.370Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
33 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
34 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
35 LIG4interactor40225.726APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
36 MCM2oncoprotein140.34645.371AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
37 MCTS1interactor120.59114.387DUF1947 (PF09183, IPR015266): Domain of unknown function (DUF1947)
PUA (PF01472, IPR002478, SM00359): PUA domain
38 MYEF2interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 MYO1Einteractor120.576153.786IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
40 NAE1interactor90.6115.858ThiF (PF00899, IPR000594): ThiF family
41 NAGKprotein found in more fusions41.0000BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
42 NDUFS3protein found in more fusions200Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
43 NME4interactor200NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
44 OGFOD1interactor160.57597.384Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term
2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
45 OXNAD1interactor100NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
46 PAFAH1B2oncoprotein70.5717.176Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
47 PAPOLAinteractor40.50039.257PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
48 PARD6Binteractor21.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
49 PCK2interactor100PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
50 PDIA4interactor190.497133.274Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
51 PHGDHinteractor40.6670.9002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
52 PHPT1interactor100Ocnus (PF05005, IPR007702): Janus/Ocnus family (Ocnus)
53 PPP1R2interactor90.52855.617IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
54 PRCPinteractor50.9000.582Peptidase_S28 (PF05577, IPR008758): Serine carboxypeptidase S28
55 PTMAoncoprotein140.68152.071Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
56 RGS17interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
57 RGS19oncoprotein100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
58 RGS20interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
59 RPA1suppressor90.53644.864Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
60 SBDSoncoprotein30.6670.667SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
61 SLC25A32interactor2017.090Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
62 SMSinteractor40.50058.423Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
63 SOX2oncoprotein40.6671.000HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
64 STK26interactor170.66760.445DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
65 SUMO3interactor100Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
66 TATDN1interactor100.46719.035TatD_DNase (PF01026, IPR001130): TatD related DNase
67 TBCBinteractor120.80332.907CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
68 TUFMinteractor110.43622.798GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
69 TWF2interactor110.6917.800Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
70 UBXN1interactor110.55611.817Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UBX (PF00789, IPR001012, SM00166): UBX domain
71 YARSinteractor30.6671.000tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
72 YWHAEoncoprotein190.46855.12314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑