Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins OS9 (from a repository: Sat Nov 12 09:27:39 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 61 The number (and %) of the onco-proteins 15 (24.59 %) The number (and %) of the tumor suppressors 6 (9.84 %) Total number of binary PPIs (saturation %) 221 (12.08 %) The number (and %) of affected PPIs 61 (27.60 %) The number of possible different fusions 8 PPI diameter 2 PPI radius 1 The average degree of PPI 6.721 Assortativity coefficient -0.4533 The network average Clustering coefficient 0.575 The number (and %) of a zero Clustering coefficients 13 (21.31 %) The number (and %) of a zero Betweenness Centrality 26 (42.62 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: OS9	All fusions : BI012638; AA037271;
Proteins found in more fusions	PLOD2 (see 1 fusions); OS9/MYH9 (see 1 fusions); OS9 (see 2 fusions); VCP (see 4 fusions); EGLN1 (see 1 fusions); EGFR (see 2 fusions); SREBF2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	OS9	parental protein	61	0.082	2654.025	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87 PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
2	ACVR1B	oncoprotein	2	1.000	0	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3	AMFR	oncoprotein	12	0.673	6.870	CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4	ASGR2	interactor	4	0.833	0.200	UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5	AUP1	interactor	8	0.821	1.287	CUE (PF02845, IPR003892, SM00546): CUE domain
6	BSG	interactor	5	0.800	0.382	Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7	CALR3	interactor	2	1.000	0	Calreticulin (PF00262, IPR001580): Calreticulin family
8	CERCAM	interactor	4	0.667	2.000	Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
9	CLN5	interactor	7	0.571	6.917	CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
10	COLGALT1	interactor	4	0.833	0.143	Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
11	CREB3	interactor	3	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
12	DCSTAMP	interactor	1	0	0	DC_STAMP (PF07782, IPR012858): DC-STAMP-like protein PrgI (PF12666, IPR024414): PrgI family protein
13	DERL2	interactor	10	0.689	6.168	DER1 (PF04511, IPR007599): Der1-like family
14	DNAJB11	interactor	7	0.762	1.614	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
15	DPEP2	interactor	1	0	0	Peptidase_M19 (PF01244, IPR008257): Membrane dipeptidase (Peptidase family M19)
16	EGFR	oncoprotein	12	0.527	19.986	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17	EGLN1	suppressor	4	1.000	0	zf-MYND (PF01753, IPR002893): MYND finger 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
18	EGLN3	suppressor	4	1.000	0	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
19	ERLEC1	interactor	14	0.418	30.012	PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
20	FAF2	interactor	16	0.524	27.094	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
21	FAM8A1	interactor	4	1.000	0	RDD (PF06271, IPR010432): RDD family
22	FBXO15	interactor	1	0	0	F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
23	FBXO6	interactor	26	0.218	196.537	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
24	FOXM1	oncoprotein	1	0	0	EspF (PF04806, IPR006891): EspF protein repeat Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
25	FOXRED2	interactor	5	0.900	0.250	Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
26	FUT9	interactor	1	0	0	Glyco_transf_10 (PF00852, IPR001503): Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N (PF17039, IPR031481): Fucosyltransferase, N-terminal
27	GABRA1	interactor	4	0.833	0.250	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
28	GGH	oncoprotein	4	1.000	0	Peptidase_C26 (PF07722, IPR011697): Peptidase C26
29	HIF1A	suppressor	6	0.467	7.333	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
30	HSP90B1	suppressor	12	0.606	11.384	CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
31	HSPA5	oncoprotein	19	0.392	57.452	HSP70 (PF00012, IPR013126): Hsp70 protein
32	HYOU1	interactor	7	0.810	0.995	HSP70 (PF00012, IPR013126): Hsp70 protein AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
33	KLK5	oncoprotein	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
34	LONP2	interactor	1	0	0	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain Phage_CP76 (PF06892, IPR009679): Phage regulatory protein CII (CP76) Sld5 (PF05916, IPR021151): GINS complex protein TIP49 (PF06068, IPR010339): TIP49 C-terminus
35	MYH9	suppressor	5	0.900	0.167	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
36	NAAA	interactor	4	0.667	0.700	CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
37	NUP210	interactor	3	0.667	0.143	Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2)
38	PLOD2	protein found in more fusions	5	0.833	0.143	2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
39	PPIB	interactor	5	0.900	0.143	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
40	RBX1	oncoprotein	4	0.667	0.500	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
41	RPN1	oncoprotein	11	0.582	10.229	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
42	SARAF	interactor	6	1.000	0	SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
43	SEL1L	oncoprotein	20	0.368	70.321	fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
44	SERPINA1	oncoprotein	5	0.800	0.536	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
45	SERPINC1	interactor	1	0	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
46	SERPINH1	interactor	5	0.800	0.543	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
47	SERPINI1	interactor	1	0	0	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
48	SMAD2	suppressor	3	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
49	SMPD1	interactor	1	0	0	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
50	SNRPD2	interactor	2	1.000	0	LSM (PF01423, IPR001163): LSM domain
51	SREBF2	protein found in more fusions	3	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
52	SYVN1	interactor	18	0.397	50.406	Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
53	TCTN1	interactor	14	0.319	36.183	DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
54	TRPV1	oncoprotein	3	1.000	0	Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
55	TRPV4	interactor	1	0	0	Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
56	UBE2J1	interactor	9	0.667	8.368	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
57	UGGT2	interactor	3	0.667	0.143	Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8 UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
58	UGT1A10	interactor	1	0	0	UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
59	VCP	protein found in more fusions	17	0.417	40.579	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
60	ZNF512B	interactor	1	0	0	YTV (PF07639, IPR011521): YTV zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
61	ZPBP2	interactor	1	0	0	Sp38 (PF07354, IPR010857): Zona-pellucida-binding protein (Sp38)

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