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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OS9 (from a repository: Sat Nov 12 09:27:39 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins15 (24.59 %)
The number (and %) of the tumor suppressors6 (9.84 %)
Total number of binary PPIs (saturation %)221 (12.08 %)
The number (and %) of affected PPIs61 (27.60 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI6.721
Assortativity coefficient-0.4533
The network average Clustering coefficient0.575
The number (and %) of a zero Clustering coefficients13 (21.31 %)
The number (and %) of a zero Betweenness Centrality26 (42.62 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OS9 All fusions
: BI012638; AA037271;
Proteins found in more fusions PLOD2 (see 1 fusions); OS9/MYH9 (see 1 fusions); OS9 (see 2 fusions); VCP (see 4 fusions); EGLN1 (see 1 fusions); EGFR (see 2 fusions); SREBF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OS9parental protein610.0822654.025DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
2 ACVR1Boncoprotein21.0000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
3 AMFRoncoprotein120.6736.870CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 ASGR2interactor40.8330.200UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
5 AUP1interactor80.8211.287CUE (PF02845, IPR003892, SM00546): CUE domain
6 BSGinteractor50.8000.382Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 CALR3interactor21.0000Calreticulin (PF00262, IPR001580): Calreticulin family
8 CERCAMinteractor40.6672.000Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
9 CLN5interactor70.5716.917CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
10 COLGALT1interactor40.8330.143Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
11 CREB3interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
12 DCSTAMPinteractor100DC_STAMP (PF07782, IPR012858): DC-STAMP-like protein
PrgI (PF12666, IPR024414): PrgI family protein
13 DERL2interactor100.6896.168DER1 (PF04511, IPR007599): Der1-like family
14 DNAJB11interactor70.7621.614DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
15 DPEP2interactor100Peptidase_M19 (PF01244, IPR008257): Membrane dipeptidase (Peptidase family M19)
16 EGFRoncoprotein120.52719.986Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 EGLN1suppressor41.0000zf-MYND (PF01753, IPR002893): MYND finger
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
18 EGLN3suppressor41.00002OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
19 ERLEC1interactor140.41830.012PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
20 FAF2interactor160.52427.094DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
21 FAM8A1interactor41.0000RDD (PF06271, IPR010432): RDD family
22 FBXO15interactor100F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
23 FBXO6interactor260.218196.537FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
24 FOXM1oncoprotein100EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
25 FOXRED2interactor50.9000.250Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
26 FUT9interactor100Glyco_transf_10 (PF00852, IPR001503): Glycosyltransferase family 10 (fucosyltransferase) C-term
Glyco_tran_10_N (PF17039, IPR031481): Fucosyltransferase, N-terminal
27 GABRA1interactor40.8330.250Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
28 GGHoncoprotein41.0000Peptidase_C26 (PF07722, IPR011697): Peptidase C26
29 HIF1Asuppressor60.4677.333Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
30 HSP90B1suppressor120.60611.384CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
31 HSPA5oncoprotein190.39257.452HSP70 (PF00012, IPR013126): Hsp70 protein
32 HYOU1interactor70.8100.995HSP70 (PF00012, IPR013126): Hsp70 protein
AbiEi_3_N (PF17194): Transcriptional regulator, AbiEi antitoxin N-terminal domain
33 KLK5oncoprotein21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
34 LONP2interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
Phage_CP76 (PF06892, IPR009679): Phage regulatory protein CII (CP76)
Sld5 (PF05916, IPR021151): GINS complex protein
TIP49 (PF06068, IPR010339): TIP49 C-terminus
35 MYH9suppressor50.9000.167IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
36 NAAAinteractor40.6670.700CBAH (PF02275, IPR003199): Linear amide C-N hydrolases, choloylglycine hydrolase family
NAAA-beta (PF15508, IPR029130): beta subunit of N-acylethanolamine-hydrolyzing acid amidase
37 NUP210interactor30.6670.143Big_2 (PF02368, IPR003343, SM00635): Bacterial Ig-like domain (group 2)
38 PLOD2protein found in more fusions50.8330.1432OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
39 PPIBinteractor50.9000.143Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
40 RBX1oncoprotein40.6670.500zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
41 RPN1oncoprotein110.58210.229Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
42 SARAFinteractor61.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
43 SEL1Loncoprotein200.36870.321fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
44 SERPINA1oncoprotein50.8000.536Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
45 SERPINC1interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
46 SERPINH1interactor50.8000.543Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
47 SERPINI1interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
48 SMAD2suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
49 SMPD1interactor100Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
50 SNRPD2interactor21.0000LSM (PF01423, IPR001163): LSM domain
51 SREBF2protein found in more fusions31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
52 SYVN1interactor180.39750.406Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
53 TCTN1interactor140.31936.183DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
54 TRPV1oncoprotein31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
55 TRPV4interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
56 UBE2J1interactor90.6678.368UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
ATPase-cat_bd (PF12156, IPR021993): Putative metal-binding domain of cation transport ATPase
57 UGGT2interactor30.6670.143Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
58 UGT1A10interactor100UDPGT (PF00201, IPR002213): UDP-glucoronosyl and UDP-glucosyl transferase
59 VCPprotein found in more fusions170.41740.579AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
60 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger
61 ZPBP2interactor100Sp38 (PF07354, IPR010857): Zona-pellucida-binding protein (Sp38)

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