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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins27 (39.71 %)
The number (and %) of the tumor suppressors6 (8.82 %)
Total number of binary PPIs (saturation %)246 (10.80 %)
The number (and %) of affected PPIs68 (27.64 %)
The number of possible different fusions20
PPI diameter2
PPI radius1
The average degree of PPI6.324
Assortativity coefficient-0.3279
The network average Clustering coefficient0.500
The number (and %) of a zero Clustering coefficients14 (20.59 %)
The number (and %) of a zero Betweenness Centrality25 (36.76 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OPTN All fusions
: CB242718;
Proteins found in more fusions GABARAP (see 2 fusions); OPTN (see 1 fusions); HSPB1 (see 4 fusions); GNAS (see 5 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); SQSTM1 (see 5 fusions); UBC (see 1 fusions); TNF (see 1 fusions); YWHAG (see 1 fusions); TFRC (see 1 fusions); RIPK1 (see 1 fusions); MYO6 (see 3 fusions); EPS15 (see 1 fusions); YWHAZ (see 1 fusions); ZDHHC17 (see 2 fusions); YWHAH (see 2 fusions); TNFRSF1A (see 2 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OPTNparental protein680.0673590.239ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
2 BREoncoprotein30.6670.400BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
3 CALM1interactor60.4007.750EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 CCDC53interactor21.0000DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
5 CDC23interactor31.0000ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
6 CDKN1Asuppressor30.6670.500CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
7 CYLDsuppressor90.5289.671CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
8 DAZAP2protein found in more fusions50.8330.182DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
9 EIF5A2interactor21.0000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
10 EPS15oncoprotein50.8330.400Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11 FAM189A2interactor50.5002.900CD20 (PF04103, IPR007237): CD20-like family
12 GABARAPsuppressor100.52812.132Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
13 GABARAPL1interactor80.6434.001Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
14 GABARAPL2interactor90.6396.418Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
15 GNASoncoprotein31.0000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
16 GRM1interactor31.00007tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR
ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318)
GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
17 HACE1suppressor200HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
18 HSPB1oncoprotein100.55610.883HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 HTTprotein found in more fusions70.4677.667HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
20 KCTD17interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
21 LNX2interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
22 MAP1LC3Ainteractor90.50012.569Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
23 MAP1LC3Binteractor90.6115.901Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
24 MAP1LC3Cinteractor50.9000.182Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
25 MPP1oncoprotein100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
26 MPP6interactor100L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
27 MYH6interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
28 MYO6protein found in more fusions70.7331.700BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
29 NRLinteractor100bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
Maf_N (PF08383, IPR013592): Maf N-terminal region
30 PARK2suppressor100.38915.415IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31 PIAS4interactor31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
32 RAB10oncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
33 RAB11Aoncoprotein40.5002.667Ras (PF00071, IPR001806, SM00173): Ras family
34 RAB11Boncoprotein40.5002.667Ras (PF00071, IPR001806, SM00173): Ras family
35 RAB12oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
36 RAB14oncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
37 RAB25suppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
38 RAB3IL1interactor40.6670.667Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
39 RAB8Aoncoprotein60.3339.667Ras (PF00071, IPR001806, SM00173): Ras family
40 RIPK1protein found in more fusions110.51112.582Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
41 RNF11protein found in more fusions100.50010.721zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
42 SLF2interactor21.0000FAM178 (PF14816, IPR026161): Family of unknown function, FAM178
MRI (PF15325, IPR028278): Modulator of retrovirus infection
43 SOD1interactor31.0000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
44 SQSTM1oncoprotein180.28767.588PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
45 STX12interactor40.5002.500PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
46 TAX1BP1interactor170.32464.021CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
47 TBC1D15interactor60.4006.633Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
48 TBC1D17interactor70.4768.917RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
49 TBK1interactor110.44414.968DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
50 TFRConcoprotein50.5002.400PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
51 TNFoncoprotein110.46715.121TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
52 TNFRSF1Aoncoprotein80.5716.067Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
53 TNIP1interactor130.43923.902ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
54 TRADDinteractor51.0000Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
55 TRAF3oncoprotein70.6672.452ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
56 UBCprotein found in more fusions220.257119.568ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57 UQCRQinteractor100UcrQ (PF02939, IPR004205): UcrQ family
58 WDR20interactor50.7003.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
59 YWHABinteractor90.6397.65014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
60 YWHAGprotein found in more fusions90.5718.98314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
61 YWHAHprotein found in more fusions90.6436.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
62 YWHAQinteractor110.40024.06714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
63 YWHAZprotein found in more fusions110.55613.11714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
64 ZDHHC17protein found in more fusions40.6671.000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
65 ZNF329interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
66 ZNF384oncoprotein100API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
67 ZNF398interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3669 (PF12417, IPR022137): Zinc finger protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
zinc_ribbon_9 (PF14369): zinc-ribbon
68 ZNF670interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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