1 |
OPTN | parental protein | 68 | 0.067 | 3590.239 | ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
2 |
BRE | oncoprotein | 3 | 0.667 | 0.400 | BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE) |
3 |
CALM1 | interactor | 6 | 0.400 | 7.750 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
4 |
CCDC53 | interactor | 2 | 1.000 | 0 | DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) |
5 |
CDC23 | interactor | 3 | 1.000 | 0 | ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23 DUF772 (PF05598, IPR008490): Transposase domain (DUF772) Menin (PF05053, IPR007747): Menin TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
6 |
CDKN1A | suppressor | 3 | 0.667 | 0.500 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
7 |
CYLD | suppressor | 9 | 0.528 | 9.671 | CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured |
8 |
DAZAP2 | protein found in more fusions | 5 | 0.833 | 0.182 | DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2) |
9 |
EIF5A2 | interactor | 2 | 1.000 | 0 | EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold |
10 |
EPS15 | oncoprotein | 5 | 0.833 | 0.400 | Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
11 |
FAM189A2 | interactor | 5 | 0.500 | 2.900 | CD20 (PF04103, IPR007237): CD20-like family |
12 |
GABARAP | suppressor | 10 | 0.528 | 12.132 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
13 |
GABARAPL1 | interactor | 8 | 0.643 | 4.001 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III |
14 |
GABARAPL2 | interactor | 9 | 0.639 | 6.418 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
15 |
GNAS | oncoprotein | 3 | 1.000 | 0 | G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit |
16 |
GRM1 | interactor | 3 | 1.000 | 0 | 7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor |
17 |
HACE1 | suppressor | 2 | 0 | 0 | HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) |
18 |
HSPB1 | oncoprotein | 10 | 0.556 | 10.883 | HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family |
19 |
HTT | protein found in more fusions | 7 | 0.467 | 7.667 | HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
20 |
KCTD17 | interactor | 2 | 0 | 0 | BTB_2 (PF02214, IPR003131): BTB/POZ domain SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) |
21 |
LNX2 | interactor | 2 | 0 | 0 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DZR (PF12773, IPR025874): Double zinc ribbon zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
22 |
MAP1LC3A | interactor | 9 | 0.500 | 12.569 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
23 |
MAP1LC3B | interactor | 9 | 0.611 | 5.901 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
24 |
MAP1LC3C | interactor | 5 | 0.900 | 0.182 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
25 |
MPP1 | oncoprotein | 1 | 0 | 0 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase P33MONOX (PF15302, IPR026759): P33 mono-oxygenase |
26 |
MPP6 | interactor | 1 | 0 | 0 | L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
27 |
MYH6 | interactor | 1 | 0 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
28 |
MYO6 | protein found in more fusions | 7 | 0.733 | 1.700 | BUD22 (PF09073, IPR015158): BUD22 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Rad9 (PF04139, IPR007268): Rad9 Sec62 (PF03839, IPR004728): Translocation protein Sec62 XhlA (PF10779, IPR019715): Haemolysin XhlA Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain |
29 |
NRL | interactor | 1 | 0 | 0 | bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region |
30 |
PARK2 | suppressor | 10 | 0.389 | 15.415 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
31 |
PIAS4 | interactor | 3 | 1.000 | 0 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain |
32 |
RAB10 | oncoprotein | 2 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
33 |
RAB11A | oncoprotein | 4 | 0.500 | 2.667 | Ras (PF00071, IPR001806, SM00173): Ras family |
34 |
RAB11B | oncoprotein | 4 | 0.500 | 2.667 | Ras (PF00071, IPR001806, SM00173): Ras family |
35 |
RAB12 | oncoprotein | 1 | 0 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
36 |
RAB14 | oncoprotein | 1 | 0 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
37 |
RAB25 | suppressor | 2 | 1.000 | 0 | Ras (PF00071, IPR001806, SM00173): Ras family |
38 |
RAB3IL1 | interactor | 4 | 0.667 | 0.667 | Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p |
39 |
RAB8A | oncoprotein | 6 | 0.333 | 9.667 | Ras (PF00071, IPR001806, SM00173): Ras family |
40 |
RIPK1 | protein found in more fusions | 11 | 0.511 | 12.582 | Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif |
41 |
RNF11 | protein found in more fusions | 10 | 0.500 | 10.721 | zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger |
42 |
SLF2 | interactor | 2 | 1.000 | 0 | FAM178 (PF14816, IPR026161): Family of unknown function, FAM178 MRI (PF15325, IPR028278): Modulator of retrovirus infection |
43 |
SOD1 | interactor | 3 | 1.000 | 0 | Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC) |
44 |
SQSTM1 | oncoprotein | 18 | 0.287 | 67.588 | PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain |
45 |
STX12 | interactor | 4 | 0.500 | 2.500 | PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal SNARE (PF05739, IPR000727, SM00397): SNARE domain DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776) Syntaxin_2 (PF14523): Syntaxin-like protein |
46 |
TAX1BP1 | interactor | 17 | 0.324 | 64.021 | CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 zf-C2H2_4 (PF13894): C2H2-type zinc finger PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain |
47 |
TBC1D15 | interactor | 6 | 0.400 | 6.633 | Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548) |
48 |
TBC1D17 | interactor | 7 | 0.476 | 8.917 | RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548) |
49 |
TBK1 | interactor | 11 | 0.444 | 14.968 | DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain |
50 |
TFRC | oncoprotein | 5 | 0.500 | 2.400 | PA (PF02225, IPR003137): PA domain Peptidase_M28 (PF04389, IPR007484): Peptidase family M28 TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855) |
51 |
TNF | oncoprotein | 11 | 0.467 | 15.121 | TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family |
52 |
TNFRSF1A | oncoprotein | 8 | 0.571 | 6.067 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
53 |
TNIP1 | interactor | 13 | 0.439 | 23.902 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
54 |
TRADD | interactor | 5 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat |
55 |
TRAF3 | oncoprotein | 7 | 0.667 | 2.452 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29 |
56 |
UBC | protein found in more fusions | 22 | 0.257 | 119.568 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
57 |
UQCRQ | interactor | 1 | 0 | 0 | UcrQ (PF02939, IPR004205): UcrQ family |
58 |
WDR20 | interactor | 5 | 0.700 | 3.000 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
59 |
YWHAB | interactor | 9 | 0.639 | 7.650 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
60 |
YWHAG | protein found in more fusions | 9 | 0.571 | 8.983 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
61 |
YWHAH | protein found in more fusions | 9 | 0.643 | 6.167 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
62 |
YWHAQ | interactor | 11 | 0.400 | 24.067 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
63 |
YWHAZ | protein found in more fusions | 11 | 0.556 | 13.117 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
64 |
ZDHHC17 | protein found in more fusions | 4 | 0.667 | 1.000 | zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies) |
65 |
ZNF329 | interactor | 1 | 0 | 0 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
66 |
ZNF384 | oncoprotein | 1 | 0 | 0 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
67 |
ZNF398 | interactor | 1 | 0 | 0 | KRAB (PF01352, IPR001909, SM00349): KRAB box zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3669 (PF12417, IPR022137): Zinc finger protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type zinc_ribbon_9 (PF14369): zinc-ribbon |
68 |
ZNF670 | interactor | 1 | 0 | 0 | KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |