Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	68
The number (and %) of the onco-proteins	27 (39.71 %)
The number (and %) of the tumor suppressors	6 (8.82 %)
Total number of binary PPIs (saturation %)	246 (10.80 %)
The number (and %) of affected PPIs	68 (27.64 %)
The number of possible different fusions	20
PPI diameter	2
PPI radius	1
The average degree of PPI	6.324
Assortativity coefficient	-0.3279
The network average Clustering coefficient	0.500
The number (and %) of a zero Clustering coefficients	14 (20.59 %)
The number (and %) of a zero Betweenness Centrality	25 (36.76 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: OPTN	All fusions : CB242718;
Proteins found in more fusions	GABARAP (see 2 fusions); OPTN (see 1 fusions); HSPB1 (see 4 fusions); GNAS (see 5 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); SQSTM1 (see 5 fusions); UBC (see 1 fusions); TNF (see 1 fusions); YWHAG (see 1 fusions); TFRC (see 1 fusions); RIPK1 (see 1 fusions); MYO6 (see 3 fusions); EPS15 (see 1 fusions); YWHAZ (see 1 fusions); ZDHHC17 (see 2 fusions); YWHAH (see 2 fusions); TNFRSF1A (see 2 fusions); HTT (see 1 fusions);

List of the fusions

PPI for parental proteins: OPTN

All fusions

: CB242718;

Proteins found in more fusions

GABARAP (see 2 fusions); OPTN (see 1 fusions); HSPB1 (see 4 fusions); GNAS (see 5 fusions); RNF11 (see 1 fusions); DAZAP2 (see 2 fusions); SQSTM1 (see 5 fusions); UBC (see 1 fusions); TNF (see 1 fusions); YWHAG (see 1 fusions); TFRC (see 1 fusions); RIPK1 (see 1 fusions); MYO6 (see 3 fusions); EPS15 (see 1 fusions); YWHAZ (see 1 fusions); ZDHHC17 (see 2 fusions); YWHAH (see 2 fusions); TNFRSF1A (see 2 fusions); HTT (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	OPTN	parental protein	68	0.067	3590.239	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
2	BRE	oncoprotein	3	0.667	0.400	BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
3	CALM1	interactor	6	0.400	7.750	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4	CCDC53	interactor	2	1.000	0	DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
5	CDC23	interactor	3	1.000	0	ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23 DUF772 (PF05598, IPR008490): Transposase domain (DUF772) Menin (PF05053, IPR007747): Menin TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
6	CDKN1A	suppressor	3	0.667	0.500	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
7	CYLD	suppressor	9	0.528	9.671	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase zf-HIT (PF04438, IPR007529): HIT zinc finger CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
8	DAZAP2	protein found in more fusions	5	0.833	0.182	DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
9	EIF5A2	interactor	2	1.000	0	EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
10	EPS15	oncoprotein	5	0.833	0.400	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
11	FAM189A2	interactor	5	0.500	2.900	CD20 (PF04103, IPR007237): CD20-like family
12	GABARAP	suppressor	10	0.528	12.132	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
13	GABARAPL1	interactor	8	0.643	4.001	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
14	GABARAPL2	interactor	9	0.639	6.418	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
15	GNAS	oncoprotein	3	1.000	0	G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
16	GRM1	interactor	3	1.000	0	7tm_3 (PF00003, IPR017978): 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) GluR_Homer-bdg (PF10606, IPR019588): Homer-binding domain of metabotropic glutamate receptor
17	HACE1	suppressor	2	0	0	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
18	HSPB1	oncoprotein	10	0.556	10.883	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19	HTT	protein found in more fusions	7	0.467	7.667	HEAT (PF02985, IPR000357): HEAT repeat SPX (PF03105, IPR004331): SPX domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3652 (PF12372, IPR024613): Huntingtin protein region Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
20	KCTD17	interactor	2	0	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
21	LNX2	interactor	2	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DZR (PF12773, IPR025874): Double zinc ribbon zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
22	MAP1LC3A	interactor	9	0.500	12.569	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
23	MAP1LC3B	interactor	9	0.611	5.901	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
24	MAP1LC3C	interactor	5	0.900	0.182	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
25	MPP1	oncoprotein	1	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
26	MPP6	interactor	1	0	0	L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
27	MYH6	interactor	1	0	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
28	MYO6	protein found in more fusions	7	0.733	1.700	BUD22 (PF09073, IPR015158): BUD22 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Rad9 (PF04139, IPR007268): Rad9 Sec62 (PF03839, IPR004728): Translocation protein Sec62 XhlA (PF10779, IPR019715): Haemolysin XhlA Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
29	NRL	interactor	1	0	0	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region
30	PARK2	suppressor	10	0.389	15.415	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
31	PIAS4	interactor	3	1.000	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
32	RAB10	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
33	RAB11A	oncoprotein	4	0.500	2.667	Ras (PF00071, IPR001806, SM00173): Ras family
34	RAB11B	oncoprotein	4	0.500	2.667	Ras (PF00071, IPR001806, SM00173): Ras family
35	RAB12	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
36	RAB14	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
37	RAB25	suppressor	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
38	RAB3IL1	interactor	4	0.667	0.667	Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
39	RAB8A	oncoprotein	6	0.333	9.667	Ras (PF00071, IPR001806, SM00173): Ras family
40	RIPK1	protein found in more fusions	11	0.511	12.582	Death (PF00531, IPR000488, SM00005): Death domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RHIM (PF12721, IPR025735): RIP homotypic interaction motif
41	RNF11	protein found in more fusions	10	0.500	10.721	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
42	SLF2	interactor	2	1.000	0	FAM178 (PF14816, IPR026161): Family of unknown function, FAM178 MRI (PF15325, IPR028278): Modulator of retrovirus infection
43	SOD1	interactor	3	1.000	0	Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
44	SQSTM1	oncoprotein	18	0.287	67.588	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
45	STX12	interactor	4	0.500	2.500	PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal SNARE (PF05739, IPR000727, SM00397): SNARE domain DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776) Syntaxin_2 (PF14523): Syntaxin-like protein
46	TAX1BP1	interactor	17	0.324	64.021	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 zf-C2H2_4 (PF13894): C2H2-type zinc finger PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
47	TBC1D15	interactor	6	0.400	6.633	Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
48	TBC1D17	interactor	7	0.476	8.917	RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
49	TBK1	interactor	11	0.444	14.968	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
50	TFRC	oncoprotein	5	0.500	2.400	PA (PF02225, IPR003137): PA domain Peptidase_M28 (PF04389, IPR007484): Peptidase family M28 TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
51	TNF	oncoprotein	11	0.467	15.121	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
52	TNFRSF1A	oncoprotein	8	0.571	6.067	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
53	TNIP1	interactor	13	0.439	23.902	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201) FlxA (PF14282, IPR025577): FlxA-like protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
54	TRADD	interactor	5	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain TPR_14 (PF13428): Tetratricopeptide repeat
55	TRAF3	oncoprotein	7	0.667	2.452	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain MPS2 (PF17060, IPR031433): Monopolar spindle protein 2 Spc29 (PF17082, IPR031392): Spindle Pole Component 29
56	UBC	protein found in more fusions	22	0.257	119.568	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
57	UQCRQ	interactor	1	0	0	UcrQ (PF02939, IPR004205): UcrQ family
58	WDR20	interactor	5	0.700	3.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
59	YWHAB	interactor	9	0.639	7.650	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
60	YWHAG	protein found in more fusions	9	0.571	8.983	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
61	YWHAH	protein found in more fusions	9	0.643	6.167	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
62	YWHAQ	interactor	11	0.400	24.067	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
63	YWHAZ	protein found in more fusions	11	0.556	13.117	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
64	ZDHHC17	protein found in more fusions	4	0.667	1.000	zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_4 (PF13637): Ankyrin repeats (many copies)
65	ZNF329	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
66	ZNF384	oncoprotein	1	0	0	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
67	ZNF398	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3669 (PF12417, IPR022137): Zinc finger protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type zinc_ribbon_9 (PF14369): zinc-ribbon
68	ZNF670	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

B a c k t o T o p ⇑

Fusion ID: Protein names:	OPTN
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List of active interactors