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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins OPA3 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins6 (23.08 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)61 (18.77 %)
The number (and %) of affected PPIs26 (42.62 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.077
Assortativity coefficient-0.1594
The network average Clustering coefficient0.651
The number (and %) of a zero Clustering coefficients5 (19.23 %)
The number (and %) of a zero Betweenness Centrality17 (65.38 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: OPA3 All fusions
: BG994363; BG994361;
Proteins found in more fusions APP (see 4 fusions); KDM1A (see 2 fusions); SUV39H1 (see 1 fusions); PHYHIPL (see 1 fusions); OPA3 (see 2 fusions); ATP5A1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 OPA3parental protein260.093467.167IL11 (PF07400, IPR020438): Interleukin 11
OPA3 (PF07047, IPR010754): Optic atrophy 3 protein (OPA3)
2 APPprotein found in more fusions90.42914.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ATP5A1protein found in more fusions140.26953.500ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
4 ATP5C1interactor50.9000.500ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
5 ATP5Jinteractor31.0000ATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
6 ATP5Ointeractor60.7332.500OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
7 C1QBPinteractor30.6670.667MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
8 CLPBinteractor100AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 COX5Ainteractor100COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
10 ECH1interactor40.6671.667ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
11 IDEinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
12 KDM1Aprotein found in more fusions31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
13 LAMC1interactor21.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_I (PF06008, IPR009254): Laminin Domain I
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LOH1CR12 (PF10158, IPR018780): Tumour suppressor protein
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
14 MTCH2interactor41.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
15 NRDCinteractor41.0000Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
16 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
17 NXF1interactor41.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 PHYHIPLprotein found in more fusions50.5002.667fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
19 PRMT6interactor21.0000Methyltransf_25 (PF13649): Methyltransferase domain
20 SCO1interactor100NA
21 SCO2interactor21.0000SCO1-SenC (PF02630, IPR003782): SCO1/SenC
22 STARD7interactor21.0000START (PF01852, IPR002913, SM00234): START domain
23 STOML2oncoprotein31.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
Band_7_C (PF16200, IPR032435): C-terminal region of band_7
24 SUV39H1protein found in more fusions40.6671.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
25 TIMM23interactor100Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
26 YME1L1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41

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