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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NTNG1, PI3 (from a repository: Mon Jan 1 08:00:46 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins1 (16.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)9 (60.00 %)
The number (and %) of affected PPIs4 (44.44 %)
The number of possible different fusions2
PPI diameter1
PPI radiusinf
The average degree of PPI2.333
Assortativity coefficient1.0000
The network average Clustering coefficient0.667
The number (and %) of a zero Clustering coefficients2 (33.33 %)
The number (and %) of a zero Betweenness Centrality6 (100.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PI3,NTNG1 All fusions
Proteins found in more fusions CSTA (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PI3parental protein31.0000WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core'
Cementoin (PF10511, IPR019541): Trappin protein transglutaminase binding domain
2 NTNG1parental protein100EGF_2 (PF07974, IPR013111): EGF-like domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
3 CSTAoncoprotein41.0000Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
4 KRT1interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
5 LORinteractor41.0000Loricrin (PF15847, IPR031700): Major keratinocyte cell envelope protein
6 LRRC4Cinteractor100I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR)
Podoplanin (PF05808, IPR008783): Podoplanin
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat

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