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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NT5C2 (from a repository: Tue Dec 6 16:44:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins2 (7.14 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)61 (16.14 %)
The number (and %) of affected PPIs28 (45.90 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI3.857
Assortativity coefficient-0.4399
The network average Clustering coefficient0.481
The number (and %) of a zero Clustering coefficients11 (39.29 %)
The number (and %) of a zero Betweenness Centrality19 (67.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NT5C2 All fusions
: BE178183; BE936897; BE178418;
Proteins found in more fusions NT5C2 (see 5 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NT5C2parental protein280.077594.3335_nucleotid (PF05761, IPR008380): 5' nucleotidase family
2 ADSLinteractor80.42915.000DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
3 API5interactor40.8330.667API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
4 ASB2interactor200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 ATP5Ointeractor100OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
6 BTF3L4interactor21.0000NAC (PF01849, IPR002715): NAC domain
7 CALM1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
8 CEP19interactor21.0000CEP19 (PF14933, IPR029412): CEP19-like protein
9 DRG2interactor31.0000MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TGS (PF02824, IPR004095): TGS domain
MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain
10 EHD4interactor50.7003.000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
11 FBF1interactor21.0000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
12 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
13 GNPDA1interactor41.0000Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
14 HERC4interactor60.9000.500RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
15 HSPBP1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like
HEAT_EZ (PF13513): HEAT-like repeat
16 MOB1Bsuppressor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
17 MOB3Binteractor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
18 MOB3Cinteractor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
19 NME7interactor100DUF1126 (PF06565, IPR010554): Repeat of unknown function (DUF1126)
NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
20 NOC4Linteractor100CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
21 NTRK1oncoprotein100.41719.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
22 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
23 PTGES3interactor200CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
24 RAD23Aoncoprotein60.9000.500UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
25 SDCBPinteractor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
26 SZRD1interactor21.0000SUZ (PF12752, IPR024771): SUZ domain
SUZ-C (PF12901, IPR024642): SUZ-C motif
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
27 USP5interactor70.6196.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
28 WARSinteractor80.6078.333tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain

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