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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NR2F2 (from a repository: Sun Dec 4 17:55:18 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins11 (37.93 %)
The number (and %) of the tumor suppressors2 (6.90 %)
Total number of binary PPIs (saturation %)51 (12.56 %)
The number (and %) of affected PPIs29 (56.86 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.966
Assortativity coefficient-0.5194
The network average Clustering coefficient0.346
The number (and %) of a zero Clustering coefficients15 (51.72 %)
The number (and %) of a zero Betweenness Centrality22 (75.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NR2F2 All fusions
: CK725089;
Proteins found in more fusions MYOD1 (see 1 fusions); SETD7 (see 2 fusions); NR3C1 (see 8 fusions); NR2F2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NR2F2parental protein290.040696.500zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
2 BCL11Aoncoprotein40.6670.500BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
3 BIKsuppressor100bcl-2I13 (PF12201, IPR024579): Bcl2-interacting killer, BH3-domain containing
4 ERGIC3oncoprotein100COPIIcoated_ERV (PF07970, IPR012936): Endoplasmic reticulum vesicle transporter
ERGIC_N (PF13850): Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
5 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
6 FCGR3Binteractor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
7 HDAC1suppressor80.33313.000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
8 HIPK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
9 HLA-DQA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
10 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
11 MPPED1interactor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
12 MYOD1oncoprotein50.6672.000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
13 NR2F6oncoprotein60.3339.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
14 NR3C1protein found in more fusions50.5002.500GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15 NSD1oncoprotein21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
16 NT5Einteractor1005_nucleotid_C (PF02872, IPR008334): 5'-nucleotidase, C-terminal domain
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
17 PHB2interactor31.0000DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
18 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
19 POU5F1oncoprotein200Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
20 RBPJinteractor21.0000BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
21 RNF13interactor100DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
22 SCN2Binteractor100DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
23 SETD7protein found in more fusions31.0000MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
24 SLAMF1interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein
25 SMARCAD1interactor21.0000CUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
26 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
27 TFAP4oncoprotein40.5002.500DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
28 TM2D3interactor100TM2 (PF05154, IPR007829): TM2 domain
29 TRIP4interactor100ASCH (PF04266, IPR007374, SM01022): ASCH domain
UxaC (PF02614, IPR003766): Glucuronate isomerase
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type

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