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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NQO1 (from a repository: Sun Dec 4 08:28:13 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins4 (16.67 %)
The number (and %) of the tumor suppressors5 (20.83 %)
Total number of binary PPIs (saturation %)68 (24.64 %)
The number (and %) of affected PPIs24 (35.29 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.833
Assortativity coefficient-0.3734
The network average Clustering coefficient0.526
The number (and %) of a zero Clustering coefficients5 (20.83 %)
The number (and %) of a zero Betweenness Centrality9 (37.50 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NQO1 All fusions
: BU189113; CB159668;
Proteins found in more fusions FOS (see 4 fusions); NQO1 (see 2 fusions); PARP1 (see 1 fusions); STUB1 (see 1 fusions); TP53 (see 3 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NQO1parental protein240.138374.700Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
2 ADKinteractor21.0000PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
3 BAG3oncoprotein60.8000.800BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 DAZAP1interactor50.7003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
5 FN1oncoprotein60.6673.167fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
6 FOSoncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
7 FUBP3interactor41.0000DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
8 GOT1interactor40.5002.333Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
9 HSPA4interactor60.7331.733Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
10 ING1suppressor21.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
11 ITGA4interactor70.6673.167FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
12 LAMB1interactor100Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
YscO (PF07321, IPR009929): Type III secretion protein YscO
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
Ntox1 (PF15500, IPR029137): Putative RNase-like toxin, toxin_1
13 MOV10interactor70.4767.467AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
14 NDUFS7interactor200Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
15 NFE2L2oncoprotein100bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
16 NME1suppressor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
17 NXF1interactor90.39312.467NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
18 PARP1suppressor80.4299.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
19 POLDIP3interactor30.6670.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 RPS10P5interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
21 RPS19interactor40.6671.333Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
22 STUB1suppressor70.7331.733U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
23 TP53suppressor90.39314.300DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
24 YTHDF1interactor30.6670.400YTH (PF04146, IPR007275): YT521-B-like domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)

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