Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	56
The number (and %) of the onco-proteins	30 (53.57 %)
The number (and %) of the tumor suppressors	1 (1.79 %)
Total number of binary PPIs (saturation %)	180 (11.69 %)
The number (and %) of affected PPIs	56 (31.11 %)
The number of possible different fusions	15
PPI diameter	2
PPI radius	1
The average degree of PPI	5.536
Assortativity coefficient	-0.3186
The network average Clustering coefficient	0.588
The number (and %) of a zero Clustering coefficients	8 (14.29 %)
The number (and %) of a zero Betweenness Centrality	25 (44.64 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: NLK	All fusions : BM450424; CN280773;
Proteins found in more fusions	CREBBP (see 5 fusions); MYBL2 (see 4 fusions); KPNB1 (see 2 fusions); TAB2 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); CUL1 (see 3 fusions); ATXN1 (see 3 fusions); SMAD4 (see 2 fusions); FOXO1 (see 1 fusions); RANGAP1 (see 2 fusions); TP53 (see 3 fusions); SKI (see 1 fusions); HIPK2 (see 1 fusions);

List of the fusions

PPI for parental proteins: NLK

All fusions

: BM450424; CN280773;

Proteins found in more fusions

CREBBP (see 5 fusions); MYBL2 (see 4 fusions); KPNB1 (see 2 fusions); TAB2 (see 1 fusions); NLK (see 4 fusions); MAP3K7 (see 7 fusions); CUL1 (see 3 fusions); ATXN1 (see 3 fusions); SMAD4 (see 2 fusions); FOXO1 (see 1 fusions); RANGAP1 (see 2 fusions); TP53 (see 3 fusions); SKI (see 1 fusions); HIPK2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	NLK	parental protein	56	0.067	2469.200	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
2	ASGR1	interactor	1	0	0	Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
3	ATXN1	protein found in more fusions	5	0.500	3.000	AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH) Spt20 (PF12090, IPR021950): Spt20 family ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
4	BACH1	interactor	3	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
5	CCP110	interactor	3	0.667	1.000	DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20 CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus CALM_bind (PF16025): Calcium-dependent calmodulin binding
6	CEP97	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif LRR_8 (PF13855, IPR001611): Leucine rich repeat LRR_9 (PF14580): Leucine-rich repeat
7	CNOT11	interactor	3	0.667	0.667	DUF2363 (PF10155, IPR019312): Uncharacterized conserved protein (DUF2363) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
8	CNOT2	interactor	5	0.500	4.667	NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family
9	CNOT3	suppressor	2	1.000	0	NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family Not3 (PF04065, IPR007207): Not1 N-terminal domain, CCR4-Not complex component Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
10	CREBBP	oncoprotein	15	0.363	42.967	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
11	CTNNB1	oncoprotein	11	0.418	23.267	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
12	CUL1	oncoprotein	11	0.311	25.433	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
13	ELAVL1	oncoprotein	14	0.282	48.333	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14	FAM222A	interactor	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1992 (PF09350, IPR018961): Domain of unknown function (DUF1992) FAM222A (PF15258, IPR029340): Protein family of FAM222A
15	FAM222B	interactor	1	0	0	FAM222A (PF15258, IPR029340): Protein family of FAM222A
16	FBXW4	oncoprotein	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
17	FBXW5	interactor	5	0.400	5.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like
18	FOXO1	oncoprotein	7	0.733	1.900	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
19	FOXO3	oncoprotein	8	0.643	4.233	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
20	FOXO4	oncoprotein	6	0.800	1.300	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
21	GRN	oncoprotein	2	1.000	0	Granulin (PF00396, IPR000118, SM00277): Granulin Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
22	HIPK2	oncoprotein	11	0.400	20.367	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
23	KPNB1	protein found in more fusions	7	0.533	4.467	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
24	KRTAP10-3	interactor	6	0.700	3.000	Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
25	KRTAP4-2	interactor	4	1.000	0	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
26	KRTAP5-6	interactor	4	1.000	0	NA
27	KRTAP5-9	interactor	4	1.000	0	Ery_res_leader2 (PF08057, IPR012559): Erythromycin resistance leader peptide
28	LEF1	oncoprotein	6	0.533	5.833	CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
29	MAP3K7	oncoprotein	6	0.400	5.500	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
30	MDM2	oncoprotein	11	0.444	18.167	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
31	MYB	oncoprotein	7	0.429	10.067	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
32	MYBL1	oncoprotein	3	1.000	0	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
33	MYBL2	oncoprotein	5	0.667	1.000	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
34	PASK	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain PAS_8 (PF13188, IPR000014): PAS domain PAS_9 (PF13426, IPR000014): PAS domain
35	PKM	oncoprotein	3	1.000	0	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
36	QRICH1	interactor	3	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1 DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504) RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
37	RANBP2	oncoprotein	7	0.533	4.633	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693) IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1 TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
38	RANGAP1	protein found in more fusions	4	1.000	0	RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
39	RCHY1	oncoprotein	4	1.000	0	C1_2 (PF03107, IPR004146): C1 domain zf-CHY (PF05495, IPR008913): CHY zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zinc_ribbon_6 (PF14599): Zinc-ribbon
40	RNF219	interactor	4	0.667	1.667	CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
41	SDR16C5	interactor	1	0	0	adh_short (PF00106, IPR002198): short chain dehydrogenase
42	SHANK2	interactor	1	0	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH3_2 (PF07653, IPR011511): Variant SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) FERM_f0 (PF16511, IPR032425): N-terminal or F0 domain of Talin-head FERM
43	SKI	oncoprotein	6	0.600	2.067	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
44	SKP2	oncoprotein	7	0.476	6.467	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
45	SMAD4	oncoprotein	11	0.422	18.100	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
46	STAT5A	oncoprotein	4	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
47	TAB2	oncoprotein	3	1.000	0	CUE (PF02845, IPR003892, SM00546): CUE domain DivIC (PF04977, IPR007060): Septum formation initiator Mnd1 (PF03962, IPR005647): Mnd1 family zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
48	TCF7L2	oncoprotein	6	0.533	5.333	CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
49	TLE3	interactor	5	0.500	2.500	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
50	TNKS1BP1	interactor	3	1.000	0	Tankyrase_bdg_C (PF15327, IPR032764): Tankyrase binding protein C terminal domain
51	TP53	oncoprotein	12	0.382	26.867	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
52	TRPS1	interactor	1	0	0	Rubredoxin (PF00301, IPR024935): Rubredoxin zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type GATA (PF00320, IPR000679, SM00401): GATA zinc finger zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_7 (PF15269): Zinc-finger
53	UBAP2L	interactor	3	0.667	1.000	CUE (PF02845, IPR003892, SM00546): CUE domain DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2 UBA_4 (PF14555): UBA-like domain Comm (PF15957, IPR031878): Commissureless
54	USP4	oncoprotein	5	0.667	2.000	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
55	WDCP	interactor	1	0	0	DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
56	ZHX3	interactor	3	1.000	0	NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain TerB_C (PF15615, IPR028932): TerB-C domain

B a c k t o T o p ⇑

Fusion ID: Protein names:	NLK
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors