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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NFE2L1 (from a repository: Sat Dec 3 15:37:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins8 (42.11 %)
The number (and %) of the tumor suppressors2 (10.53 %)
Total number of binary PPIs (saturation %)49 (28.65 %)
The number (and %) of affected PPIs19 (38.78 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.895
Assortativity coefficient-0.4677
The network average Clustering coefficient0.535
The number (and %) of a zero Clustering coefficients6 (31.58 %)
The number (and %) of a zero Betweenness Centrality12 (63.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NFE2L1 All fusions
: AA633217;
Proteins found in more fusions HCFC1 (see 2 fusions); CREBZF (see 1 fusions); GSK3B (see 1 fusions); NFE2L1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NFE2L1parental protein190.124248.667bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
2 BACH2oncoprotein41.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
3 BRD9interactor100TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3512 (PF12024, IPR021900): Domain of unknown function (DUF3512)
4 BTRConcoprotein60.7002.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
6 CAPN1interactor100Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
7 CD6oncoprotein100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
TMEM154 (PF15102, IPR028064): TMEM154 protein family
8 CREBZFprotein found in more fusions31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
9 FBXW11interactor60.7002.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
10 FBXW7suppressor50.8330.667Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
11 GSK3Bsuppressor70.5336.667Pkinase (PF00069, IPR000719): Protein kinase domain
12 HCFC1protein found in more fusions50.6672.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
13 JUNoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
14 KEAP1oncoprotein41.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
15 MAFFinteractor51.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
16 MAFGoncoprotein51.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
ThrE_2 (PF12821, IPR024528): Threonine/Serine exporter, ThrE
17 NFE2L3interactor70.6006.000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
18 RUSC2interactor100RUN (PF02759, IPR004012, SM00593): RUN domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
19 WDFY3interactor100Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)

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