Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins NELFB (from a repository: Sun Dec 4 11:57:18 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 48 The number (and %) of the onco-proteins 16 (33.33 %) The number (and %) of the tumor suppressors 3 (6.25 %) Total number of binary PPIs (saturation %) 280 (24.82 %) The number (and %) of affected PPIs 48 (17.14 %) The number of possible different fusions 6 PPI diameter 2 PPI radius 1 The average degree of PPI 11.042 Assortativity coefficient -0.1555 The network average Clustering coefficient 0.669 The number (and %) of a zero Clustering coefficients 4 (8.33 %) The number (and %) of a zero Betweenness Centrality 12 (25.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: NELFB	All fusions : BG827779;
Proteins found in more fusions	PTBP1 (see 1 fusions); NELFB (see 1 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); MSH2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	NELFB	parental protein	48	0.202	1131.291	COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
2	ABCF1	interactor	17	0.824	5.199	ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037) ABC_tran_Xtn (PF12848, IPR032781): ABC transporter AAA_18 (PF13238): AAA domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
3	ALDH3A2	interactor	1	0	0	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4	ATP1A1	interactor	6	0.733	2.667	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase Tetraspannin (PF00335, IPR018499): Tetraspanin family Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5	BRCA1	suppressor	13	0.439	20.569	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6	CCT8	interactor	4	1.000	0	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7	CEBPE	interactor	4	1.000	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
8	DDX1	oncoprotein	17	0.787	7.368	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9	DENR	oncoprotein	1	0	0	SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
10	DHX9	oncoprotein	18	0.627	27.394	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11	DIMT1	interactor	15	0.733	8.281	RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
12	EDC4	interactor	12	0.939	0.630	DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
13	EIF2B2	interactor	17	0.794	6.336	IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
14	EIF2B3	interactor	16	0.800	9.308	NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase NAGPA (PF09992, IPR018711): Phosphodiester glycosidase DUF4954 (PF16314, IPR032533): Domain of unknown function (DUF4954)
15	EIF3C	oncoprotein	5	0.600	3.154	eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI (PF01399, IPR000717, SM00088): PCI domain
16	ELP6	interactor	1	0	0	ELP6 (PF09807, IPR018627): Elongation complex protein 6
17	ESR1	suppressor	18	0.331	61.167	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
18	FKBP3	interactor	15	0.819	5.317	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
19	FOS	oncoprotein	5	0.833	0.667	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
20	HNRNPU	interactor	23	0.530	57.237	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
21	HSPA9	oncoprotein	4	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
22	IGF2BP3	interactor	18	0.758	9.968	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
23	ILF2	interactor	22	0.615	33.731	DZF (PF07528, IPR006561, SM00572): DZF domain
24	JUN	oncoprotein	7	0.667	4.000	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
25	KHDRBS3	interactor	3	1.000	0	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
26	MAPK6	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
27	MGST1	interactor	1	0	0	MAPEG (PF01124, IPR001129): MAPEG family
28	MRE11A	oncoprotein	16	0.771	11.514	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
29	MSH2	suppressor	8	0.619	3.802	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III AAA_27 (PF13514): AAA domain
30	NCBP1	interactor	5	1.000	0	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain MIF4G_like (PF09088, IPR015172): MIF4G like MIF4G_like_2 (PF09090, IPR015174): MIF4G like SlyX (PF04102, IPR007236): SlyX
31	NELFA	interactor	10	0.578	11.300	CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
32	NELFCD	oncoprotein	7	0.762	2.500	TH1 (PF04858, IPR006942): TH1 protein
33	NELFE	interactor	7	0.810	1.733	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
34	NMT1	oncoprotein	19	0.737	11.750	NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein NST1 (PF13945, IPR025279): Salt tolerance down-regulator
35	NTRK1	oncoprotein	30	0.298	213.002	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36	PA2G4	interactor	9	0.722	2.420	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
37	POLR2A	protein found in more fusions	11	0.578	9.617	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
38	POLR2C	interactor	9	0.643	6.133	RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
39	PTBP1	oncoprotein	11	0.733	4.641	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40	RAD51	interactor	5	1.000	0	Rad51 (PF08423, IPR013632): Rad51 HHH_5 (PF14520): Helix-hairpin-helix domain
41	RFC4	interactor	17	0.794	9.022	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
42	RPL23A	interactor	10	0.756	3.142	Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23 Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
43	RPN1	oncoprotein	7	0.619	5.067	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
44	SUPT5H	interactor	8	0.607	5.002	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
45	SYNCRIP	interactor	10	0.622	11.100	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
46	YBX1	oncoprotein	15	0.600	15.152	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
47	YBX3	interactor	14	0.824	4.817	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
48	YWHAB	interactor	3	1.000	0	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor

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