Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NELFB (from a repository: Sun Dec 4 11:57:18 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins16 (33.33 %)
The number (and %) of the tumor suppressors3 (6.25 %)
Total number of binary PPIs (saturation %)280 (24.82 %)
The number (and %) of affected PPIs48 (17.14 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI11.042
Assortativity coefficient-0.1555
The network average Clustering coefficient0.669
The number (and %) of a zero Clustering coefficients4 (8.33 %)
The number (and %) of a zero Betweenness Centrality12 (25.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NELFB All fusions
: BG827779;
Proteins found in more fusions PTBP1 (see 1 fusions); NELFB (see 1 fusions); FOS (see 4 fusions); POLR2A (see 2 fusions); MSH2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NELFBparental protein480.2021131.291COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
2 ABCF1interactor170.8245.199ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_18 (PF13238): AAA domain
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
3 ALDH3A2interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 ATP1A1interactor60.7332.667Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 BRCA1suppressor130.43920.569BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
6 CCT8interactor41.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CEBPEinteractor41.0000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
8 DDX1oncoprotein170.7877.368DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
9 DENRoncoprotein100SUI1 (PF01253, IPR001950): Translation initiation factor SUI1
10 DHX9oncoprotein180.62727.394DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 DIMT1interactor150.7338.281RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
12 EDC4interactor120.9390.630DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
13 EIF2B2interactor170.7946.336IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
14 EIF2B3interactor160.8009.308NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
DUF4954 (PF16314, IPR032533): Domain of unknown function (DUF4954)
15 EIF3Concoprotein50.6003.154eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
PCI (PF01399, IPR000717, SM00088): PCI domain
16 ELP6interactor100ELP6 (PF09807, IPR018627): Elongation complex protein 6
17 ESR1suppressor180.33161.167Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
18 FKBP3interactor150.8195.317FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
19 FOSoncoprotein50.8330.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
20 HNRNPUinteractor230.53057.237CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
21 HSPA9oncoprotein41.0000HSP70 (PF00012, IPR013126): Hsp70 protein
22 IGF2BP3interactor180.7589.968RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
23 ILF2interactor220.61533.731DZF (PF07528, IPR006561, SM00572): DZF domain
24 JUNoncoprotein70.6674.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
25 KHDRBS3interactor31.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
26 MAPK6oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
27 MGST1interactor100MAPEG (PF01124, IPR001129): MAPEG family
28 MRE11Aoncoprotein160.77111.514APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
29 MSH2suppressor80.6193.802MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
30 NCBP1interactor51.0000MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
31 NELFAinteractor100.57811.300CathepsinC_exc (PF08773, IPR014882): Cathepsin C exclusion domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
32 NELFCDoncoprotein70.7622.500TH1 (PF04858, IPR006942): TH1 protein
33 NELFEinteractor70.8101.733DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
FLO_LFY (PF01698, IPR002910): Floricaula / Leafy protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
34 NMT1oncoprotein190.73711.750NMT (PF01233, IPR022676): Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
NMT_C (PF02799, IPR022677): Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
35 NTRK1oncoprotein300.298213.002I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
36 PA2G4interactor90.7222.420Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
37 POLR2Aprotein found in more fusions110.5789.617RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
38 POLR2Cinteractor90.6436.133RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
39 PTBP1oncoprotein110.7334.641RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 RAD51interactor51.0000Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
41 RFC4interactor170.7949.022AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
42 RPL23Ainteractor100.7563.142Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
43 RPN1oncoprotein70.6195.067Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
44 SUPT5Hinteractor80.6075.002KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
45 SYNCRIPinteractor100.62211.100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
46 YBX1oncoprotein150.60015.152CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
47 YBX3interactor140.8244.817CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
48 YWHABinteractor31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

B a c k    t o    T o p ⇑