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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NECTIN3 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins3 (10.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)71 (16.32 %)
The number (and %) of affected PPIs30 (42.25 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.933
Assortativity coefficient-0.5420
The network average Clustering coefficient0.417
The number (and %) of a zero Clustering coefficients14 (46.67 %)
The number (and %) of a zero Betweenness Centrality18 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NECTIN3 All fusions
Proteins found in more fusions NECTIN3 (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NECTIN3parental protein300.074727.233Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 AFDNoncoprotein30.6671.000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
3 ASPHinteractor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
Asp_Arg_Hydrox (PF05118, IPR007803): Aspartyl/Asparaginyl beta-hydroxylase
LUC7 (PF03194, IPR004882): LUC7 N_terminus
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
4 BAG3oncoprotein200BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
5 CHMP4Binteractor200Snf7 (PF03357, IPR005024): Snf7
6 COL14A1interactor100CBM_4_9 (PF02018, IPR003305): Carbohydrate binding domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
7 ERO1Binteractor21.0000ERO1 (PF04137, IPR007266): Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
8 FBXO2interactor21.0000FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain
9 FBXO7interactor100Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
PI31_Prot_N (PF11566, IPR021625): PI31 proteasome regulator N-terminal
F-box-like (PF12937, IPR001810): F-box-like
10 FBXW7oncoprotein200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
11 INPP5Kinteractor100CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
12 KRTAP10-3interactor90.8212.233Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
13 KRTAP10-7interactor90.8212.233Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
14 KRTAP10-8interactor80.9520.333Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
15 KRTAP10-9interactor80.9520.333Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
16 KRTAP4-2interactor70.7625.000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
17 LGALS8interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
18 MAKinteractor200Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
19 NECTIN1interactor40.6671.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
20 NECTIN2interactor70.5336.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
21 NLRP3interactor100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
22 NOTCH2NLinteractor80.8212.233EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
23 NPTX1interactor100IncA (PF04156, IPR007285): IncA protein
MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
24 PARD3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
25 PDK1interactor200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
26 PPP4R3Ainteractor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
27 PVRinteractor70.7624.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
CD34_antigen (PF06365, IPR013836): CD34/Podocalyxin family
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
28 RGS20interactor21.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
29 SDF2interactor100MIR (PF02815, IPR016093, SM00472): MIR domain
30 TIGITinteractor30.6670.400Cpta_toxin (PF07254, IPR009883): Membrane-bound toxin component of toxin-antitoxin system
NMN_transporter (PF04973, IPR006419): Nicotinamide mononucleotide transporter
V-set (PF07686, IPR013106): Immunoglobulin V-set domain

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