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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins3 (10.34 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)90 (22.17 %)
The number (and %) of affected PPIs29 (32.22 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI5.724
Assortativity coefficient-0.5334
The network average Clustering coefficient0.644
The number (and %) of a zero Clustering coefficients4 (13.79 %)
The number (and %) of a zero Betweenness Centrality14 (48.28 %)


List of the fusions

PPI for parental proteins: NDUFAF8 All fusions
Proteins found in more fusions NDUFS3 (see 1 fusions); NDUFAF8 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 NDUFAF8parental protein290.146457.100ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
2 ATP5C1interactor60.7332.133ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
3 ATP5Einteractor31.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
4 ATP5F1interactor70.7622.467Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
5 ATP5Hinteractor60.8001.400Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
6 ATP5Ointeractor50.9000.400OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
7 C14orf159interactor200DUF1445 (PF07286, IPR009906): Protein of unknown function (DUF1445)
DUF4392 (PF14336, IPR025504): Domain of unknown function (DUF4392)
8 C1QBPinteractor31.0000MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
9 CHCHD2interactor140.37233.600CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
10 CLPBinteractor40.6670.800AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
11 COX6A1interactor31.0000COX6A (PF02046, IPR001349): Cytochrome c oxidase subunit VIa
12 CPT2interactor21.0000Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
13 DHRS4interactor120.45520.100adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
14 ECH1interactor60.6672.600ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 MRPL54interactor100Ribosomal_L37 (PF08561, IPR013870): Mitochondrial ribosomal protein L37
16 MRPS35interactor21.0000MRP-S28 (PF10213, IPR019349): Mitochondrial ribosomal subunit protein
17 NDUFA5interactor31.0000ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
18 NDUFAF5interactor80.5248.333Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
19 NDUFS3protein found in more fusions200.263102.567Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
20 NFS1interactor100Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
21 PI4KAinteractor100PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Ipi1_N (PF12333, IPR024679): Rix1 complex component involved in 60S ribosome maturation
Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
22 PMPCAinteractor51.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
23 PMPCBinteractor60.7332.200Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
24 POLDIP2interactor50.7001.200DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
25 SLC16A1oncoprotein21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
26 STARD7interactor21.0000START (PF01852, IPR002913, SM00234): START domain
27 STOML2oncoprotein41.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
Band_7_C (PF16200, IPR032435): C-terminal region of band_7
28 TIMM50interactor30.6670.400NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
29 TRUB2interactor80.28610.700TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain

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