Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NDUFAF4 (from a repository: Thu Nov 17 16:52:36 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)37
The number (and %) of the onco-proteins3 (8.11 %)
The number (and %) of the tumor suppressors1 (2.70 %)
Total number of binary PPIs (saturation %)176 (26.43 %)
The number (and %) of affected PPIs37 (21.02 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI9.027
Assortativity coefficient-0.4261
The network average Clustering coefficient0.760
The number (and %) of a zero Clustering coefficients1 (2.70 %)
The number (and %) of a zero Betweenness Centrality14 (37.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NDUFAF4 All fusions
: BU680050;
Proteins found in more fusions NDUFS3 (see 1 fusions); NDUFAF4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NDUFAF4parental protein370.208616.236UPF0240 (PF06784, IPR009622): Uncharacterised protein family (UPF0240)
2 ABCE1interactor50.8330.250ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ACAD9interactor110.8911.501Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ACIN1interactor30.6670.667Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
FAM27 (PF15832, IPR031672): FAM27 D and E protein family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
5 ATP5C1interactor51.0000ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 ATP5Einteractor31.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
7 BCKDHAinteractor21.0000E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
8 C15orf48interactor200.41659.647B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
9 C1QBPinteractor51.0000MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
10 C2orf47interactor130.56114.687Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
11 CHCHD4interactor21.0000CHCH (PF06747, IPR010625): CHCH domain
Voldacs (PF03517): Regulator of volume decrease after cellular swelling
12 COQ9interactor190.45841.006COQ9 (PF08511, IPR013718): COQ9
13 DHX15interactor40.5002.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
14 DHX9oncoprotein40.5002.667DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 ECH1interactor41.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
16 ECSITinteractor130.69713.072ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
17 HNRNPFinteractor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
18 HTRA2suppressor31.0000Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
19 IGF2BP3interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
20 NDUFA13interactor140.70312.859GRIM-19 (PF06212, IPR009346): GRIM-19 protein
21 NDUFA5interactor110.6189.955ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
22 NDUFAF1interactor81.0000CIA30 (PF08547, IPR013857): Complex I intermediate-associated protein 30 (CIA30)
23 NDUFAF3interactor140.7696.145DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
24 NDUFB10interactor70.9050.500NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
25 NDUFB5interactor60.9330.200NDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
26 NDUFS2interactor140.7258.992Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
27 NDUFS3protein found in more fusions280.339155.402Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
28 NDUFS5interactor160.61724.531Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
29 NDUFS7interactor160.66712.729Oxidored_q6 (PF01058, IPR006137): NADH ubiquinone oxidoreductase, 20 Kd subunit
30 NDUFS8interactor100.8891.118Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
Fer4_16 (PF13484): 4Fe-4S double cluster binding domain
31 NUDT19interactor100NUDIX (PF00293, IPR000086): NUDIX domain
32 PITRM1interactor31.0000M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
33 PMPCAinteractor61.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
34 PMPCBinteractor61.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
35 POLDIP2interactor41.0000DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
36 POU5F1oncoprotein60.9000.222Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
37 TIMMDC1interactor150.66712.282Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family

B a c k    t o    T o p ⇑