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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins18 (27.69 %)
The number (and %) of the tumor suppressors3 (4.62 %)
Total number of binary PPIs (saturation %)319 (15.34 %)
The number (and %) of affected PPIs65 (20.38 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI8.892
Assortativity coefficient-0.2699
The network average Clustering coefficient0.577
The number (and %) of a zero Clustering coefficients3 (4.62 %)
The number (and %) of a zero Betweenness Centrality12 (18.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NDC80 All fusions
: CA311030;
Proteins found in more fusions PSMC2 (see 1 fusions); NDEL1 (see 1 fusions); BUB1 (see 1 fusions); NDC80 (see 1 fusions); AMOTL2 (see 1 fusions); TXLNA (see 3 fusions); NDE1 (see 3 fusions); OFD1 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NDC80parental protein650.1122740.585DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Ndc80_HEC (PF03801, IPR005550): HEC/Ndc80p family
SlyX (PF04102, IPR007236): SlyX
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
2 AMOTL2protein found in more fusions50.5002.500HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
3 ATF4oncoprotein40.6670.500bZIP_1 (PF00170, IPR004827): bZIP transcription factor
4 ATP5Ointeractor30.6670.333OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
5 AURKAoncoprotein80.5247.341Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
6 AURKBinteractor110.46712.033Pkinase (PF00069, IPR000719): Protein kinase domain
7 BLOC1S6interactor80.6194.333BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
8 BUB1oncoprotein150.63716.361Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
9 BUB1Boncoprotein150.51626.108Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
10 CALCOCO1interactor21.0000CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
11 CCDC53interactor70.7142.419DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
12 CCDC68interactor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
13 CCHCR1interactor120.41822.652HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
14 CCNB1oncoprotein90.36115.933Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
15 CCNHoncoprotein30.6671.0005_3_exonuc_N (PF02739, IPR020046): 5'-3' exonuclease, N-terminal resolvase-like domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
16 CCNKinteractor31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
17 CDC5Linteractor140.48724.675OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18 CENPHinteractor31.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
19 DCTN1interactor120.32724.971Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
20 DSN1interactor120.7279.172MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
21 ESR1suppressor60.4005.167Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
22 HAUS1interactor120.50915.667THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
23 HGSinteractor60.4006.852FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
24 IFT20interactor70.7142.333IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
25 IFT81interactor50.9000.400Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Nif11 (PF07862, IPR012903): Nitrogen fixation protein of unknown function
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
NPBW (PF15180, IPR013297): Neuropeptides B and W
26 INPP1interactor21.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
27 KLC3interactor60.5005.000TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TPR_12 (PF13424): Tetratricopeptide repeat
28 KLHL12interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
29 KNL1oncoprotein120.7586.906DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
30 KRT6Binteractor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
31 MED4interactor170.36855.941Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
32 MFAP1interactor50.5005.000MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
33 MIS12interactor110.8185.206DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
34 NDE1protein found in more fusions80.4766.467NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
35 NDEL1protein found in more fusions40.6670.400HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
36 NEK2interactor50.5001.467Pkinase (PF00069, IPR000719): Protein kinase domain
37 NSL1interactor110.8363.439Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
38 NTRK1oncoprotein170.35055.989I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
39 NUF2interactor190.43363.839Nuf2 (PF03800, IPR005549): Nuf2 family
DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
40 NXF1interactor140.29540.967NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
41 OFD1protein found in more fusions160.37141.119APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
42 PCM1oncoprotein170.37552.308FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
43 PFDN1interactor21.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
44 PLK1suppressor120.45518.533Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
45 PLS1interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46 PPP1CConcoprotein90.33318.900Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
47 PSMC2protein found in more fusions80.6673.786AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
48 RUFY4interactor100DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
RUN (PF02759, IPR004012, SM00593): RUN domain
49 SFR1interactor30.6670.500Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
50 SGF29interactor40.8330.400DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
51 SHMT2interactor60.4676.167SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
52 SKA1interactor100.44416.033SKA1 (PF07160, IPR009829): Spindle and kinetochore-associated protein 1
53 SMC1Aoncoprotein90.6796.022SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
54 SNW1protein found in more fusions170.42540.960SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
55 SPC24interactor160.47543.200DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
56 SPC25interactor100.8444.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
57 SPICE1interactor80.7143.733SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression
ANXA2R (PF15721, IPR031449): Annexin-2 receptor
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
58 STX11interactor80.4769.400KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
59 TFIP11interactor120.27340.138G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
60 TNIP1interactor51.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
61 TOM1L1interactor21.0000GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
62 TP53BP2suppressor100.44418.267ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
63 TXLNAprotein found in more fusions130.47020.019Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
64 USHBP1interactor140.29546.086DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
65 ZWINTinteractor110.9560.472Zwint (PF15556, IPR029092): ZW10 interactor

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