Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins NCOA1 (from a repository: Fri Nov 11 23:20:15 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 101 The number (and %) of the onco-proteins 39 (38.61 %) The number (and %) of the tumor suppressors 28 (27.72 %) Total number of binary PPIs (saturation %) 744 (14.73 %) The number (and %) of affected PPIs 101 (13.58 %) The number of possible different fusions 28 PPI diameter 2 PPI radius 1 The average degree of PPI 13.743 Assortativity coefficient -0.2536 The network average Clustering coefficient 0.558 The number (and %) of a zero Clustering coefficients 4 (3.96 %) The number (and %) of a zero Betweenness Centrality 20 (19.80 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: NCOA1	All fusions : AW204594; AA319820;
Proteins found in more fusions	PPARD (see 1 fusions); CXADR (see 1 fusions); VDR (see 2 fusions); AHR (see 1 fusions); VCP (see 4 fusions); FOXO1 (see 1 fusions); NR3C1 (see 8 fusions); NFKB1 (see 2 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); KAT2B (see 1 fusions); SF1 (see 1 fusions); RARA (see 4 fusions); UBR5 (see 4 fusions); FOS (see 4 fusions); RXRA (see 2 fusions); COPS5 (see 1 fusions); SMARCC1 (see 2 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); CCND1 (see 1 fusions); THRA (see 3 fusions); TP53 (see 3 fusions); SMAD3 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	NCOA1	parental protein	101	0.120	5004.528	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
2	AHR	suppressor	10	0.722	2.887	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAS_4 (PF08448, IPR013656): PAS fold
3	ANIB1	interactor	2	1.000	0	NA
4	ANKRD11	interactor	3	1.000	0	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Pap_E4 (PF02711, IPR003861): E4 protein MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term AAA_11 (PF13086): AAA domain Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
5	AR	oncoprotein	29	0.376	85.531	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
6	ARID1A	suppressor	14	0.429	24.496	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
7	ARNT	oncoprotein	6	0.867	0.619	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
8	ASCC1	interactor	5	0.900	0.154	AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain KH_1 (PF00013, IPR004088, SM00322): KH domain
9	BCL3	oncoprotein	11	0.655	5.466	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
10	BRCA1	suppressor	26	0.420	69.348	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11	CARM1	oncoprotein	17	0.449	24.292	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
12	CCND1	oncoprotein	12	0.636	6.065	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
13	CIITA	oncoprotein	6	0.667	1.317	NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
14	COPS5	protein found in more fusions	19	0.320	61.250	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15	CREBBP	suppressor	38	0.366	169.273	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16	CXADR	protein found in more fusions	3	1.000	0	Syndecan (PF01034, IPR027789): Syndecan domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Ig_3 (PF13927): Immunoglobulin domain
17	EP300	oncoprotein	52	0.272	445.733	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
18	ESR1	suppressor	43	0.242	355.197	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
19	ESR2	suppressor	14	0.500	11.224	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
20	ESRRA	oncoprotein	6	0.600	3.351	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21	ESRRG	oncoprotein	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
22	ETS1	oncoprotein	15	0.648	12.604	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
23	ETS2	suppressor	10	0.844	1.172	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
24	EZH2	suppressor	10	0.417	8.080	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
25	FOS	oncoprotein	20	0.456	36.709	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
26	FOXA2	suppressor	1	0	0	Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region HNF_C (PF09354, IPR018533): HNF3 C-terminal domain TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
27	FOXO1	suppressor	11	0.644	4.825	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
28	GTF2B	interactor	12	0.561	13.066	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
29	HIF1A	suppressor	15	0.619	13.037	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
30	HNF1A	oncoprotein	9	0.643	2.739	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31	HNF4A	suppressor	17	0.442	26.538	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
32	HNF4G	interactor	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
33	HSPA2	interactor	3	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
34	HSPA5	oncoprotein	7	0.733	1.543	HSP70 (PF00012, IPR013126): Hsp70 protein
35	ITCH	interactor	10	0.556	9.569	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
36	JUN	oncoprotein	30	0.384	99.709	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
37	KANK2	interactor	4	1.000	0	KN_motif (PF12075, IPR021939): KN motif Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
38	KAT2B	protein found in more fusions	21	0.405	46.651	Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
39	KCTD3	interactor	2	1.000	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
40	NCOA2	oncoprotein	36	0.268	243.562	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
41	NCOA3	oncoprotein	44	0.247	381.641	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
42	NCOA6	oncoprotein	30	0.330	129.414	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
43	NCOR1	oncoprotein	32	0.306	152.688	BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) MAS20 (PF02064, IPR002056): MAS20 protein import receptor Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein Hid1 (PF12722): High-temperature-induced dauer-formation protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) RBR (PF17208): RNA binding Region
44	NFKB1	suppressor	23	0.351	67.092	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
45	NKX2-1	oncoprotein	5	1.000	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
46	NR1H2	oncoprotein	9	0.667	2.441	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
47	NR1H3	interactor	9	0.583	3.726	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
48	NR1H4	interactor	9	0.667	2.539	LRV_FeS (PF05484, IPR008665): LRV protein FeS4 cluster zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
49	NR1I2	suppressor	10	0.467	7.460	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50	NR1I3	interactor	6	0.733	0.751	PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
51	NR2F6	oncoprotein	8	0.464	4.621	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
52	NR3C1	protein found in more fusions	28	0.348	104.753	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
53	NR3C2	oncoprotein	7	0.667	1.480	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
54	NR4A1	suppressor	14	0.571	10.086	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55	NR5A1	interactor	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PRIMA1 (PF16101): Proline-rich membrane anchor 1
56	NR5A2	interactor	3	0.667	0.118	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
57	NR6A1	interactor	2	0	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
58	PAGR1	interactor	3	1.000	0	PAXIP1_C (PF15364, IPR028213): PAXIP1-associated-protein-1 C term PTIP binding protein
59	PGR	suppressor	16	0.400	23.733	Prog_receptor (PF02161, IPR000128): Progesterone receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
60	PPARA	suppressor	10	0.600	4.607	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
61	PPARD	oncoprotein	10	0.556	3.580	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
62	PPARG	suppressor	25	0.409	59.109	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
63	PPARGC1A	interactor	22	0.307	84.911	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
64	PRMT1	interactor	16	0.533	17.315	Methyltransf_25 (PF13649): Methyltransferase domain
65	RABGGTB	oncoprotein	1	0	0	Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
66	RARA	oncoprotein	20	0.363	47.988	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
67	RARB	suppressor	5	0.500	2.067	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
68	RARG	oncoprotein	7	0.476	3.521	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
69	RBBP6	oncoprotein	4	0.833	0.182	DUF936 (PF06075, IPR010341): Plant protein of unknown function (DUF936) DWNN (PF08783, IPR014891): DWNN domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region U-box (PF04564, IPR003613, SM00504): U-box domain SBF2 (PF12335, IPR022096): Myotubularin protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 PRIMA1 (PF16101): Proline-rich membrane anchor 1
70	RNF4	interactor	7	0.667	1.437	Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
71	RORA	interactor	4	0.500	0.804	zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
72	RORB	interactor	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
73	RXRA	oncoprotein	33	0.282	178.652	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
74	RXRB	interactor	13	0.231	21.697	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
75	SF1	protein found in more fusions	6	0.600	3.000	UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181) zf-CCHC (PF00098, IPR001878): Zinc knuckle KH_1 (PF00013, IPR004088, SM00322): KH domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein PRIMA1 (PF16101): Proline-rich membrane anchor 1 SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
76	SMAD3	oncoprotein	26	0.493	47.360	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
77	SMARCA4	suppressor	24	0.377	71.057	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
78	SMARCC1	suppressor	17	0.550	15.218	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
79	SMARCE1	interactor	16	0.425	27.014	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
80	SNW1	protein found in more fusions	13	0.576	11.054	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
81	SRF	interactor	10	0.583	8.663	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
82	STAT3	suppressor	19	0.438	28.144	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
83	STAT5A	suppressor	12	0.564	6.047	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
84	STAT6	oncoprotein	11	0.655	3.726	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT6_C (PF14596, IPR028187): STAT6 C-terminal
85	SYTL2	interactor	1	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain MSC (PF09402, IPR018996): Man1-Src1p-C-terminal domain FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
86	TBP	interactor	19	0.490	28.598	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
87	TEAD1	interactor	2	1.000	0	TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
88	TEAD2	interactor	2	1.000	0	TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
89	THRA	suppressor	13	0.439	18.420	C1_2 (PF03107, IPR004146): C1 domain zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
90	THRB	suppressor	14	0.410	14.212	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
91	TP53	suppressor	38	0.321	211.997	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
92	TRIM21	interactor	5	0.500	1.122	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
93	TRIM24	suppressor	14	0.346	13.123	PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) zf-MYND (PF01753, IPR002893): MYND finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 Imm68 (PF15583, IPR028276): Immunity protein 68 SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
94	TRIP11	oncoprotein	2	1.000	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1529 (PF07485, IPR011094): Domain of Unknown Function (DUF1259) DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349) ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF3138 (PF11336, IPR021485): Protein of unknown function (DUF3138) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
95	TRIP4	interactor	13	0.500	12.279	ASCH (PF04266, IPR007374, SM01022): ASCH domain UxaC (PF02614, IPR003766): Glucuronate isomerase zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
96	UBE2L3	interactor	9	0.286	11.610	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
97	UBR5	protein found in more fusions	9	0.464	7.801	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
98	VCP	protein found in more fusions	16	0.362	36.614	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
99	VDR	suppressor	19	0.582	19.696	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
100	WDHD1	interactor	2	1.000	0	PVL_ORF50 (PF07768, IPR011688): PVL ORF-50-like family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Mcl1_mid (PF12341, IPR022100): Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
101	YWHAQ	interactor	9	0.528	6.297	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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