Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins NCL (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 228 The number (and %) of the onco-proteins 96 (42.11 %) The number (and %) of the tumor suppressors 10 (4.39 %) Total number of binary PPIs (saturation %) 3775 (14.59 %) The number (and %) of affected PPIs 228 (6.04 %) The number of possible different fusions 49 PPI diameter 2 PPI radius 1 The average degree of PPI 32.298 Assortativity coefficient -0.1233 The network average Clustering coefficient 0.477 The number (and %) of a zero Clustering coefficients 5 (2.19 %) The number (and %) of a zero Betweenness Centrality 13 (5.70 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: NCL	All fusions : AW581869; H43223; BQ302417;
Proteins found in more fusions	GRK5 (see 2 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); RANGAP1 (see 2 fusions); VHL (see 1 fusions); RPA1 (see 1 fusions); SUZ12 (see 2 fusions); PTBP1 (see 1 fusions); CUL4A (see 4 fusions); RPS24/RPS23 (see 1 fusions); HSP90AA1 (see 2 fusions); PRMT5 (see 2 fusions); HUWE1 (see 2 fusions); PLOD2 (see 1 fusions); SRPK2 (see 1 fusions); YY1 (see 2 fusions); HNRNPD (see 1 fusions); BAG3 (see 4 fusions); KMT2A (see 15 fusions); CSNK2A1 (see 1 fusions); EZH2 (see 1 fusions); NCL (see 3 fusions); STAU1 (see 2 fusions); NTRK1/RPL7A (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); NAP1L1 (see 3 fusions); MYC (see 1 fusions); PIK3R1 (see 1 fusions); SKI (see 1 fusions); TAF4 (see 4 fusions); COPS5 (see 1 fusions); UBC (see 1 fusions); TP53 (see 3 fusions); SREK1 (see 4 fusions); LMNA (see 3 fusions); CRY2 (see 3 fusions); NCL/NAP1L1 (see 1 fusions); NR3C1 (see 8 fusions); NAP1L4 (see 3 fusions); KPNB1 (see 2 fusions); PABPC1 (see 2 fusions); SP1 (see 1 fusions); MCM2 (see 1 fusions); FN1/RPL6 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	NCL	parental protein	228	0.135	19658.205	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
2	ACLY	interactor	20	0.479	15.533	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
3	ADAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain
4	ADAP2	interactor	1	0	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain
5	AKAP5	interactor	2	1.000	0	WSK (PF03832, IPR001573): WSK motif
6	ANAPC1	oncoprotein	10	0.489	7.844	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1
7	ANAPC7	interactor	12	0.400	16.371	TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
8	ANP32B	oncoprotein	13	0.359	5.454	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide SDA1 (PF05285, IPR007949): SDA1 LRR_9 (PF14580): Leucine-rich repeat
9	ARFGEF1	interactor	5	0.600	1.429	DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2
10	ARRB1	interactor	26	0.403	55.291	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11	ARRB2	interactor	47	0.406	107.597	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
12	AURKA	oncoprotein	23	0.472	19.387	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
13	BAG3	oncoprotein	19	0.275	34.730	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
14	BMI1	oncoprotein	33	0.280	146.461	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
15	CAND1	interactor	82	0.382	520.627	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
16	CBX5	suppressor	19	0.222	61.378	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
17	CBX6	interactor	7	0.667	1.484	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain CBX7_C (PF17218): CBX family C-terminal motif
18	CBX8	interactor	19	0.484	18.559	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
19	CCDC8	interactor	53	0.404	172.394	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
20	CD3E	interactor	3	0.667	1.000	ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
21	CD3EAP	interactor	7	0.333	9.040	Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
22	CD4	suppressor	14	0.410	10.858	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
23	CD81	interactor	31	0.492	40.130	Tetraspannin (PF00335, IPR018499): Tetraspanin family
24	CDC27	oncoprotein	10	0.444	8.993	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat
25	CDK1	oncoprotein	24	0.292	48.073	Pkinase (PF00069, IPR000719): Protein kinase domain
26	CDKN1A	oncoprotein	20	0.468	30.685	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
27	CDKN2A	oncoprotein	24	0.388	46.072	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
28	CLK1	interactor	13	0.364	18.397	PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain
29	COPS5	protein found in more fusions	76	0.426	321.293	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
30	COPS6	interactor	31	0.646	28.191	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
31	CRY2	protein found in more fusions	17	0.367	17.912	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
32	CSNK2A1	oncoprotein	52	0.270	334.005	Pkinase (PF00069, IPR000719): Protein kinase domain
33	CSNK2A2	interactor	20	0.400	27.780	Pkinase (PF00069, IPR000719): Protein kinase domain
34	CTCF	oncoprotein	11	0.509	5.593	cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
35	CUL1	oncoprotein	77	0.389	391.946	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
36	CUL2	suppressor	57	0.507	119.870	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
37	CUL3	protein found in more fusions	98	0.314	937.487	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
38	CUL4A	protein found in more fusions	37	0.446	89.552	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
39	CUL4B	oncoprotein	51	0.526	90.386	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
40	CUL5	suppressor	58	0.512	155.354	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
41	CUL7	protein found in more fusions	66	0.366	269.178	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
42	CYFIP1	interactor	4	0.667	0.784	DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
43	DAXX	oncoprotein	19	0.294	42.596	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
44	DCAF1	protein found in more fusions	22	0.500	27.247	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
45	DCUN1D1	interactor	32	0.692	16.324	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
46	DDX24	interactor	27	0.510	42.743	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tti2 (PF10521, IPR018870): Tti2 family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
47	DGCR8	interactor	8	0.607	2.442	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif WW (PF00397, IPR001202, SM00456): WW domain
48	DHX9	oncoprotein	62	0.353	262.362	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49	DNM1	interactor	6	0.500	2.012	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
50	EBNA1BP2	interactor	27	0.615	29.658	Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
51	EED	suppressor	59	0.312	295.468	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52	EIF3A	oncoprotein	30	0.320	78.565	DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
53	EIF3C	oncoprotein	26	0.458	43.061	eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI (PF01399, IPR000717, SM00088): PCI domain
54	EIF3D	interactor	20	0.395	37.937	eIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
55	EIF3G	interactor	14	0.577	7.193	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
56	EIF3L	interactor	23	0.526	18.850	Paf67 (PF10255, IPR019382): RNA polymerase I-associated factor PAF67
57	EIF5B	interactor	14	0.363	19.812	GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 MIase (PF02426, IPR026029): Muconolactone delta-isomerase NOA36 (PF06524, IPR010531): NOA36 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) IF-2 (PF11987, IPR023115): Translation-initiation factor 2 DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4 DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) Coilin_N (PF15862, IPR031722): Coilin N-terminus DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
58	ELAVL1	oncoprotein	60	0.263	448.541	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
59	ERG	oncoprotein	12	0.530	2.314	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
60	ESR1	oncoprotein	71	0.348	510.722	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
61	ETS1	oncoprotein	6	0.600	2.350	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
62	EXOSC2	interactor	6	0.600	1.520	EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region KH_6 (PF15985, IPR004088): KH domain
63	EZH2	oncoprotein	21	0.405	30.249	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
64	FBL	interactor	62	0.382	316.201	Fibrillarin (PF01269, IPR000692): Fibrillarin
65	FBXO25	suppressor	10	0.622	3.465	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
66	FMR1	interactor	9	0.429	6.513	Agenet (PF05641, IPR008395, SM00743): Agenet domain KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXMR_C2 (PF16098, IPR032196): Fragile X-related mental retardation protein C-terminal region 2
67	FN1	oncoprotein	72	0.351	340.094	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
68	FYTTD1	interactor	6	0.800	0.486	FYTT (PF07078, IPR009782): Forty-two-three protein
69	GAN	interactor	21	0.547	12.766	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
70	GRB2	oncoprotein	21	0.484	30.672	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
71	GRK5	protein found in more fusions	16	0.305	13.870	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
72	GTF2F1	interactor	5	0.800	0.177	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
73	GZF1	interactor	4	1.000	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
74	H2AFX	oncoprotein	32	0.363	73.196	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
75	H3F3A	oncoprotein	16	0.483	15.247	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
76	HDGF	interactor	23	0.265	44.214	PWWP (PF00855, IPR000313, SM00293): PWWP domain
77	HIST1H1C	oncoprotein	34	0.285	101.220	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
78	HIST2H2AC	interactor	15	0.505	11.617	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
79	HIST2H2BE	interactor	29	0.345	70.764	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
80	HIST3H3	interactor	29	0.271	122.138	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
81	HMGA1	oncoprotein	20	0.432	26.969	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
82	HNRNPA1	interactor	79	0.301	599.974	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
83	HNRNPD	oncoprotein	52	0.278	207.255	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
84	HNRNPK	oncoprotein	67	0.309	365.821	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
85	HSP90AA1	oncoprotein	71	0.253	681.300	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
86	HUWE1	oncoprotein	55	0.345	238.734	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
87	ICAM1	oncoprotein	35	0.471	46.526	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
88	IFIT1	interactor	4	0.667	0.554	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268) TPR_19 (PF14559): Tetratricopeptide repeat
89	IFIT3	interactor	8	0.619	3.074	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
90	IGSF8	oncoprotein	37	0.468	53.648	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
91	IL7R	interactor	18	0.386	16.677	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
92	ILF3	oncoprotein	86	0.393	536.565	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
93	IRF2	interactor	4	0.833	0.100	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
94	ITGA4	interactor	52	0.419	129.890	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
95	KCTD12	interactor	5	0.500	1.382	BTB_2 (PF02214, IPR003131): BTB/POZ domain
96	KMT2A	oncoprotein	13	0.424	17.851	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
97	KPNB1	protein found in more fusions	41	0.258	189.852	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
98	KRAS	oncoprotein	20	0.234	59.992	Ras (PF00071, IPR001806, SM00173): Ras family
99	LMNA	protein found in more fusions	30	0.342	90.048	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
100	MCM2	oncoprotein	74	0.347	450.610	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
101	MCM5	oncoprotein	34	0.362	82.288	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
102	MDC1	oncoprotein	26	0.338	87.429	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
103	MDK	oncoprotein	3	0.667	0.250	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
104	MDM2	oncoprotein	50	0.309	245.617	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
105	MGMT	interactor	14	0.407	11.285	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
106	MRPS26	interactor	9	0.694	1.539	MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
107	MYB	oncoprotein	5	0.600	2.067	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
108	MYBBP1A	oncoprotein	37	0.517	55.552	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
109	MYBL1	interactor	1	0	0	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
110	MYC	oncoprotein	32	0.353	74.302	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
111	NAP1L1	protein found in more fusions	37	0.517	93.162	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
112	NAP1L4	protein found in more fusions	22	0.405	47.701	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
113	NBN	oncoprotein	14	0.396	24.741	FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
114	NCBP1	interactor	23	0.379	29.518	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain MIF4G_like (PF09088, IPR015172): MIF4G like MIF4G_like_2 (PF09090, IPR015174): MIF4G like SlyX (PF04102, IPR007236): SlyX
115	NDRG1	oncoprotein	16	0.692	5.203	Ndr (PF03096, IPR004142): Ndr family
116	NEDD8	interactor	37	0.598	30.321	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117	NFE4	interactor	2	1.000	0	NA
118	NFX1	interactor	8	0.750	1.522	R3H (PF01424, IPR001374, SM00393): R3H domain XPG_I (PF00867, IPR006086, SM00484): XPG I-region zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
119	NOP56	interactor	54	0.569	104.395	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
120	NOP9	interactor	7	0.524	3.879	PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
121	NPM1	oncoprotein	112	0.293	1441.816	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
122	NPM3	interactor	5	0.500	2.020	Nucleoplasmin (PF03066): Nucleoplasmin
123	NR3C1	protein found in more fusions	10	0.556	4.502	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
124	NSUN2	interactor	17	0.478	14.058	Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
125	NTRK1	oncoprotein	103	0.230	1569.255	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
126	NUP62	interactor	10	0.500	6.633	Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
127	OBSL1	interactor	63	0.321	286.262	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
128	OXCT1	interactor	3	1.000	0	CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
129	PA2G4	interactor	25	0.557	16.471	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
130	PABPC1	oncoprotein	70	0.410	374.127	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
131	PAN2	interactor	44	0.590	83.840	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
132	PHF5A	interactor	9	0.444	5.225	PHF5 (PF03660, IPR005345): PHF5-like protein
133	PIK3R1	oncoprotein	8	0.667	5.293	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
134	PLOD2	protein found in more fusions	10	0.417	7.143	2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2
135	PNPT1	interactor	5	0.800	0.259	PNPase (PF03726, IPR015848): Polyribonucleotide nucleotidyltransferase, RNA binding domain RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2 S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain KH_1 (PF00013, IPR004088, SM00322): KH domain
136	POLR1C	interactor	12	0.439	14.968	RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
137	POU5F1	oncoprotein	21	0.237	45.346	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
138	PPP1CB	interactor	14	0.385	13.158	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
139	PRKCZ	interactor	9	0.607	6.842	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
140	PRMT1	interactor	32	0.353	71.961	Methyltransf_25 (PF13649): Methyltransferase domain
141	PRMT5	protein found in more fusions	30	0.222	115.607	PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
142	PSMA3	interactor	26	0.387	46.949	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
143	PTBP1	oncoprotein	41	0.406	103.741	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
144	PTGS1	interactor	1	0	0	An_peroxidase (PF03098, IPR002007): Animal haem peroxidase EGF (PF00008, IPR000742, SM00181): EGF-like domain
145	PTMA	oncoprotein	9	0.361	7.992	Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
146	RANGAP1	protein found in more fusions	18	0.471	17.926	RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
147	RBM42	interactor	6	0.800	0.430	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1
148	RBM46	interactor	1	0	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 (PF16367, IPR000504): RNA recognition motif
149	RCN1	interactor	9	0.472	4.473	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
150	RDX	interactor	7	0.476	2.731	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
151	RECQL5	oncoprotein	5	0.600	1.806	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component
152	RFXAP	interactor	1	0	0	RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
153	RNF146	interactor	5	0.667	0.244	WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
154	RNF2	interactor	72	0.240	671.520	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
155	RPA1	suppressor	48	0.470	109.542	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
156	RPA2	oncoprotein	42	0.490	76.779	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
157	RPA3	interactor	38	0.494	61.142	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
158	RPL11	suppressor	69	0.559	132.197	Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
159	RPL14	interactor	66	0.571	176.241	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family
160	RPL15	interactor	67	0.593	99.298	Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
161	RPL18	interactor	70	0.556	149.315	Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
162	RPL18A	interactor	53	0.663	101.804	Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
163	RPL19	interactor	59	0.643	66.271	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
164	RPL21	interactor	53	0.728	31.253	Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
165	RPL24	interactor	59	0.603	115.928	MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
166	RPL3	interactor	63	0.623	99.921	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
167	RPL4	interactor	69	0.552	195.975	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
168	RPL5	oncoprotein	71	0.557	197.877	Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
169	RPL6	protein found in more fusions	78	0.498	287.362	Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
170	RPL7	interactor	66	0.602	102.393	Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain
171	RPL7A	protein found in more fusions	58	0.632	77.172	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
172	RPL8	interactor	65	0.585	106.898	Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
173	RPL9	interactor	61	0.660	50.921	Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
174	RPS16	interactor	62	0.608	100.717	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
175	RPS19	interactor	56	0.586	118.422	Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
176	RPS2	interactor	70	0.526	189.717	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
177	RPS23	protein found in more fusions	51	0.655	66.900	Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
178	RPS24	protein found in more fusions	55	0.705	39.293	Fascin (PF06268, IPR022768): Fascin domain Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
179	RPS26	interactor	43	0.729	31.685	Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
180	RPS3A	interactor	77	0.509	220.622	Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
181	RPS4X	interactor	75	0.522	195.647	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
182	RPS5	interactor	55	0.634	60.302	Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
183	RPS6	interactor	74	0.520	223.656	Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
184	RPS6KB2	interactor	22	0.506	17.364	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
185	RPS8	interactor	81	0.471	317.155	Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
186	RRP1B	interactor	24	0.493	27.360	Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
187	S100A11	suppressor	4	1.000	0	S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
188	SCARNA22	interactor	17	0.426	20.485	NA
189	SEPT9	oncoprotein	7	0.667	0.379	Septin (PF00735, IPR000038): Septin DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
190	SF3B4	interactor	16	0.450	19.808	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
191	SIRT7	interactor	75	0.267	636.720	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
192	SKI	oncoprotein	13	0.621	10.381	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
193	SMURF1	interactor	30	0.352	52.920	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
194	SP1	protein found in more fusions	18	0.382	39.844	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
195	SPG20	interactor	4	1.000	0	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
196	SREK1	protein found in more fusions	15	0.549	8.203	Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
197	SRPK2	oncoprotein	31	0.310	111.330	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
198	SRPK3	interactor	12	0.379	11.127	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain
199	SRSF5	interactor	21	0.471	30.111	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
200	SSB	interactor	30	0.329	89.420	HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
201	STAU1	protein found in more fusions	54	0.470	162.459	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
202	SUPT4H1	interactor	6	0.600	2.186	Spt4 (PF06093, IPR022800): Spt4/RpoE2 zinc finger
203	SUPT5H	interactor	21	0.410	45.653	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
204	SUPT6H	interactor	14	0.440	19.816	Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SH2_2 (PF14633, IPR000980): SH2 domain HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6 HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6 PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal DLD (PF14878, IPR027999): Death-like domain of SPT6
205	SUZ12	oncoprotein	33	0.268	136.810	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
206	SWAP70	oncoprotein	6	0.600	1.698	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) GrpE (PF01025, IPR000740): GrpE PH (PF00169, IPR001849, SM00233): PH domain CotJB (PF12652, IPR024207): CotJB protein EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
207	TAF4	protein found in more fusions	10	0.472	11.386	TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
208	TARDBP	interactor	63	0.510	135.010	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
209	TERF2	interactor	29	0.246	109.284	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
210	TERT	oncoprotein	10	0.444	4.821	RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
211	TOP1	oncoprotein	43	0.377	133.720	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
212	TP53	oncoprotein	82	0.331	658.157	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
213	U2AF2	protein found in more fusions	50	0.441	125.693	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
214	UBC	protein found in more fusions	63	0.301	412.634	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
215	UBL4A	interactor	39	0.646	46.930	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
216	UNK	interactor	14	0.319	20.164	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
217	UQCRC2	oncoprotein	9	0.500	3.573	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
218	USP7	oncoprotein	32	0.346	80.110	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
219	VCAM1	interactor	52	0.407	118.296	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
220	VHL	oncoprotein	40	0.409	102.124	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
221	WDR43	interactor	7	0.667	0.609	Utp12 (PF04003, IPR007148): Dip2/Utp12 Family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Zip (PF02535, IPR003689): ZIP Zinc transporter ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
222	XRCC5	suppressor	51	0.256	233.078	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
223	XRCC6	oncoprotein	54	0.272	295.554	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
224	YWHAQ	interactor	38	0.323	135.740	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
225	YY1	protein found in more fusions	21	0.442	27.666	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
226	ZBTB1	interactor	12	0.864	0.756	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
227	ZFP36	oncoprotein	3	0.667	0.095	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
228	ZNF689	interactor	2	1.000	0	A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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