1 |
NCL | parental protein | 228 | 0.135 | 19658.205 | DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1 |
2 |
ACLY | interactor | 20 | 0.479 | 15.533 | ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding |
3 |
ADAP1 | interactor | 2 | 1.000 | 0 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain |
4 |
ADAP2 | interactor | 1 | 0 | 0 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain |
5 |
AKAP5 | interactor | 2 | 1.000 | 0 | WSK (PF03832, IPR001573): WSK motif |
6 |
ANAPC1 | oncoprotein | 10 | 0.489 | 7.844 | PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat ANAPC1 (PF12859, IPR024990): Anaphase-promoting complex subunit 1 |
7 |
ANAPC7 | interactor | 12 | 0.400 | 16.371 | TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
8 |
ANP32B | oncoprotein | 13 | 0.359 | 5.454 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide SDA1 (PF05285, IPR007949): SDA1 LRR_9 (PF14580): Leucine-rich repeat |
9 |
ARFGEF1 | interactor | 5 | 0.600 | 1.429 | DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec7 (PF01369, IPR000904, SM00222): Sec7 domain Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal DCB (PF16213, IPR032629): Dimerisation and cyclophilin-binding domain of Mon2 |
10 |
ARRB1 | interactor | 26 | 0.403 | 55.291 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
11 |
ARRB2 | interactor | 47 | 0.406 | 107.597 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
12 |
AURKA | oncoprotein | 23 | 0.472 | 19.387 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
13 |
BAG3 | oncoprotein | 19 | 0.275 | 34.730 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
14 |
BMI1 | oncoprotein | 33 | 0.280 | 146.461 | zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
15 |
CAND1 | interactor | 82 | 0.382 | 520.627 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
16 |
CBX5 | suppressor | 19 | 0.222 | 61.378 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain |
17 |
CBX6 | interactor | 7 | 0.667 | 1.484 | Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain CBX7_C (PF17218): CBX family C-terminal motif |
18 |
CBX8 | interactor | 19 | 0.484 | 18.559 | Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif |
19 |
CCDC8 | interactor | 53 | 0.404 | 172.394 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
20 |
CD3E | interactor | 3 | 0.667 | 1.000 | ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif P5-ATPase (PF12409, IPR006544): P5-type ATPase cation transporter Ig_5 (PF16681): Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain |
21 |
CD3EAP | interactor | 7 | 0.333 | 9.040 | Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 |
22 |
CD4 | suppressor | 14 | 0.410 | 10.858 | ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region |
23 |
CD81 | interactor | 31 | 0.492 | 40.130 | Tetraspannin (PF00335, IPR018499): Tetraspanin family |
24 |
CDC27 | oncoprotein | 10 | 0.444 | 8.993 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat |
25 |
CDK1 | oncoprotein | 24 | 0.292 | 48.073 | Pkinase (PF00069, IPR000719): Protein kinase domain |
26 |
CDKN1A | oncoprotein | 20 | 0.468 | 30.685 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
27 |
CDKN2A | oncoprotein | 24 | 0.388 | 46.072 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
28 |
CLK1 | interactor | 13 | 0.364 | 18.397 | PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region Pkinase (PF00069, IPR000719): Protein kinase domain |
29 |
COPS5 | protein found in more fusions | 76 | 0.426 | 321.293 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
30 |
COPS6 | interactor | 31 | 0.646 | 28.191 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
31 |
CRY2 | protein found in more fusions | 17 | 0.367 | 17.912 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
32 |
CSNK2A1 | oncoprotein | 52 | 0.270 | 334.005 | Pkinase (PF00069, IPR000719): Protein kinase domain |
33 |
CSNK2A2 | interactor | 20 | 0.400 | 27.780 | Pkinase (PF00069, IPR000719): Protein kinase domain |
34 |
CTCF | oncoprotein | 11 | 0.509 | 5.593 | cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal |
35 |
CUL1 | oncoprotein | 77 | 0.389 | 391.946 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
36 |
CUL2 | suppressor | 57 | 0.507 | 119.870 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
37 |
CUL3 | protein found in more fusions | 98 | 0.314 | 937.487 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
38 |
CUL4A | protein found in more fusions | 37 | 0.446 | 89.552 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
39 |
CUL4B | oncoprotein | 51 | 0.526 | 90.386 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
40 |
CUL5 | suppressor | 58 | 0.512 | 155.354 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
41 |
CUL7 | protein found in more fusions | 66 | 0.366 | 269.178 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
42 |
CYFIP1 | interactor | 4 | 0.667 | 0.784 | DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394) FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family |
43 |
DAXX | oncoprotein | 19 | 0.294 | 42.596 | Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) |
44 |
DCAF1 | protein found in more fusions | 22 | 0.500 | 27.247 | DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated |
45 |
DCUN1D1 | interactor | 32 | 0.692 | 16.324 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
46 |
DDX24 | interactor | 27 | 0.510 | 42.743 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Sec62 (PF03839, IPR004728): Translocation protein Sec62 Tti2 (PF10521, IPR018870): Tti2 family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
47 |
DGCR8 | interactor | 8 | 0.607 | 2.442 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif WW (PF00397, IPR001202, SM00456): WW domain |
48 |
DHX9 | oncoprotein | 62 | 0.353 | 262.362 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
49 |
DNM1 | interactor | 6 | 0.500 | 2.012 | Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family |
50 |
EBNA1BP2 | interactor | 27 | 0.615 | 29.658 | Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 |
51 |
EED | suppressor | 59 | 0.312 | 295.468 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
52 |
EIF3A | oncoprotein | 30 | 0.320 | 78.565 | DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
53 |
EIF3C | oncoprotein | 26 | 0.458 | 43.061 | eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI (PF01399, IPR000717, SM00088): PCI domain |
54 |
EIF3D | interactor | 20 | 0.395 | 37.937 | eIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) |
55 |
EIF3G | interactor | 14 | 0.577 | 7.193 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3 |
56 |
EIF3L | interactor | 23 | 0.526 | 18.850 | Paf67 (PF10255, IPR019382): RNA polymerase I-associated factor PAF67 |
57 |
EIF5B | interactor | 14 | 0.363 | 19.812 | GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 MIase (PF02426, IPR026029): Muconolactone delta-isomerase NOA36 (PF06524, IPR010531): NOA36 protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) IF-2 (PF11987, IPR023115): Translation-initiation factor 2 DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4 DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) Coilin_N (PF15862, IPR031722): Coilin N-terminus DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) |
58 |
ELAVL1 | oncoprotein | 60 | 0.263 | 448.541 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
59 |
ERG | oncoprotein | 12 | 0.530 | 2.314 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
60 |
ESR1 | oncoprotein | 71 | 0.348 | 510.722 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
61 |
ETS1 | oncoprotein | 6 | 0.600 | 2.350 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
62 |
EXOSC2 | interactor | 6 | 0.600 | 1.520 | EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region KH_6 (PF15985, IPR004088): KH domain |
63 |
EZH2 | oncoprotein | 21 | 0.405 | 30.249 | CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
64 |
FBL | interactor | 62 | 0.382 | 316.201 | Fibrillarin (PF01269, IPR000692): Fibrillarin |
65 |
FBXO25 | suppressor | 10 | 0.622 | 3.465 | Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A |
66 |
FMR1 | interactor | 9 | 0.429 | 6.513 | Agenet (PF05641, IPR008395, SM00743): Agenet domain KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXMR_C2 (PF16098, IPR032196): Fragile X-related mental retardation protein C-terminal region 2 |
67 |
FN1 | oncoprotein | 72 | 0.351 | 340.094 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
68 |
FYTTD1 | interactor | 6 | 0.800 | 0.486 | FYTT (PF07078, IPR009782): Forty-two-three protein |
69 |
GAN | interactor | 21 | 0.547 | 12.766 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif |
70 |
GRB2 | oncoprotein | 21 | 0.484 | 30.672 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
71 |
GRK5 | protein found in more fusions | 16 | 0.305 | 13.870 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
72 |
GTF2F1 | interactor | 5 | 0.800 | 0.177 | TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) |
73 |
GZF1 | interactor | 4 | 1.000 | 0 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
74 |
H2AFX | oncoprotein | 32 | 0.363 | 73.196 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
75 |
H3F3A | oncoprotein | 16 | 0.483 | 15.247 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
76 |
HDGF | interactor | 23 | 0.265 | 44.214 | PWWP (PF00855, IPR000313, SM00293): PWWP domain |
77 |
HIST1H1C | oncoprotein | 34 | 0.285 | 101.220 | Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349) |
78 |
HIST2H2AC | interactor | 15 | 0.505 | 11.617 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
79 |
HIST2H2BE | interactor | 29 | 0.345 | 70.764 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
80 |
HIST3H3 | interactor | 29 | 0.271 | 122.138 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
81 |
HMGA1 | oncoprotein | 20 | 0.432 | 26.969 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239) |
82 |
HNRNPA1 | interactor | 79 | 0.301 | 599.974 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
83 |
HNRNPD | oncoprotein | 52 | 0.278 | 207.255 | CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head |
84 |
HNRNPK | oncoprotein | 67 | 0.309 | 365.821 | ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
85 |
HSP90AA1 | oncoprotein | 71 | 0.253 | 681.300 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
86 |
HUWE1 | oncoprotein | 55 | 0.345 | 238.734 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
87 |
ICAM1 | oncoprotein | 35 | 0.471 | 46.526 | Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
88 |
IFIT1 | interactor | 4 | 0.667 | 0.554 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat DUF4268 (PF14088, IPR025364): Domain of unknown function (DUF4268) TPR_19 (PF14559): Tetratricopeptide repeat |
89 |
IFIT3 | interactor | 8 | 0.619 | 3.074 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat |
90 |
IGSF8 | oncoprotein | 37 | 0.468 | 53.648 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
91 |
IL7R | interactor | 18 | 0.386 | 16.677 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
92 |
ILF3 | oncoprotein | 86 | 0.393 | 536.565 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain |
93 |
IRF2 | interactor | 4 | 0.833 | 0.100 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor |
94 |
ITGA4 | interactor | 52 | 0.419 | 129.890 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
95 |
KCTD12 | interactor | 5 | 0.500 | 1.382 | BTB_2 (PF02214, IPR003131): BTB/POZ domain |
96 |
KMT2A | oncoprotein | 13 | 0.424 | 17.851 | AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
97 |
KPNB1 | protein found in more fusions | 41 | 0.258 | 189.852 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat |
98 |
KRAS | oncoprotein | 20 | 0.234 | 59.992 | Ras (PF00071, IPR001806, SM00173): Ras family |
99 |
LMNA | protein found in more fusions | 30 | 0.342 | 90.048 | Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
100 |
MCM2 | oncoprotein | 74 | 0.347 | 450.610 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
101 |
MCM5 | oncoprotein | 34 | 0.362 | 82.288 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
102 |
MDC1 | oncoprotein | 26 | 0.338 | 87.429 | FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
103 |
MDK | oncoprotein | 3 | 0.667 | 0.250 | PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain |
104 |
MDM2 | oncoprotein | 50 | 0.309 | 245.617 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
105 |
MGMT | interactor | 14 | 0.407 | 11.285 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
106 |
MRPS26 | interactor | 9 | 0.694 | 1.539 | MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 |
107 |
MYB | oncoprotein | 5 | 0.600 | 2.067 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
108 |
MYBBP1A | oncoprotein | 37 | 0.517 | 55.552 | DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal |
109 |
MYBL1 | interactor | 1 | 0 | 0 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
110 |
MYC | oncoprotein | 32 | 0.353 | 74.302 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
111 |
NAP1L1 | protein found in more fusions | 37 | 0.517 | 93.162 | NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term |
112 |
NAP1L4 | protein found in more fusions | 22 | 0.405 | 47.701 | NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) |
113 |
NBN | oncoprotein | 14 | 0.396 | 24.741 | FHA (PF00498, IPR000253, SM00240): FHA domain Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
114 |
NCBP1 | interactor | 23 | 0.379 | 29.518 | MIF4G (PF02854, IPR003890, SM00543): MIF4G domain MIF4G_like (PF09088, IPR015172): MIF4G like MIF4G_like_2 (PF09090, IPR015174): MIF4G like SlyX (PF04102, IPR007236): SlyX |
115 |
NDRG1 | oncoprotein | 16 | 0.692 | 5.203 | Ndr (PF03096, IPR004142): Ndr family |
116 |
NEDD8 | interactor | 37 | 0.598 | 30.321 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
117 |
NFE4 | interactor | 2 | 1.000 | 0 | NA |
118 |
NFX1 | interactor | 8 | 0.750 | 1.522 | R3H (PF01424, IPR001374, SM00393): R3H domain XPG_I (PF00867, IPR006086, SM00484): XPG I-region zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger |
119 |
NOP56 | interactor | 54 | 0.569 | 104.395 | Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal |
120 |
NOP9 | interactor | 7 | 0.524 | 3.879 | PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat |
121 |
NPM1 | oncoprotein | 112 | 0.293 | 1441.816 | Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain |
122 |
NPM3 | interactor | 5 | 0.500 | 2.020 | Nucleoplasmin (PF03066): Nucleoplasmin |
123 |
NR3C1 | protein found in more fusions | 10 | 0.556 | 4.502 | GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
124 |
NSUN2 | interactor | 17 | 0.478 | 14.058 | Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F |
125 |
NTRK1 | oncoprotein | 103 | 0.230 | 1569.255 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
126 |
NUP62 | interactor | 10 | 0.500 | 6.633 | Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region |
127 |
OBSL1 | interactor | 63 | 0.321 | 286.262 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
128 |
OXCT1 | interactor | 3 | 1.000 | 0 | CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase |
129 |
PA2G4 | interactor | 25 | 0.557 | 16.471 | Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein |
130 |
PABPC1 | oncoprotein | 70 | 0.410 | 374.127 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT |
131 |
PAN2 | interactor | 44 | 0.590 | 83.840 | RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain |
132 |
PHF5A | interactor | 9 | 0.444 | 5.225 | PHF5 (PF03660, IPR005345): PHF5-like protein |
133 |
PIK3R1 | oncoprotein | 8 | 0.667 | 5.293 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
134 |
PLOD2 | protein found in more fusions | 10 | 0.417 | 7.143 | 2OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily Anp1 (PF03452, IPR005109): Anp1 Glycos_transf_2 (PF00535, IPR001173): Glycosyl transferase family 2 |
135 |
PNPT1 | interactor | 5 | 0.800 | 0.259 | PNPase (PF03726, IPR015848): Polyribonucleotide nucleotidyltransferase, RNA binding domain RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2 S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
136 |
POLR1C | interactor | 12 | 0.439 | 14.968 | RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain |
137 |
POU5F1 | oncoprotein | 21 | 0.237 | 45.346 | Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
138 |
PPP1CB | interactor | 14 | 0.385 | 13.158 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
139 |
PRKCZ | interactor | 9 | 0.607 | 6.842 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
140 |
PRMT1 | interactor | 32 | 0.353 | 71.961 | Methyltransf_25 (PF13649): Methyltransferase domain |
141 |
PRMT5 | protein found in more fusions | 30 | 0.222 | 115.607 | PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase |
142 |
PSMA3 | interactor | 26 | 0.387 | 46.949 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
143 |
PTBP1 | oncoprotein | 41 | 0.406 | 103.741 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
144 |
PTGS1 | interactor | 1 | 0 | 0 | An_peroxidase (PF03098, IPR002007): Animal haem peroxidase EGF (PF00008, IPR000742, SM00181): EGF-like domain |
145 |
PTMA | oncoprotein | 9 | 0.361 | 7.992 | Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family |
146 |
RANGAP1 | protein found in more fusions | 18 | 0.471 | 17.926 | RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain SDA1 (PF05285, IPR007949): SDA1 LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
147 |
RBM42 | interactor | 6 | 0.800 | 0.430 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
148 |
RBM46 | interactor | 1 | 0 | 0 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 (PF16367, IPR000504): RNA recognition motif |
149 |
RCN1 | interactor | 9 | 0.472 | 4.473 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
150 |
RDX | interactor | 7 | 0.476 | 2.731 | ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
151 |
RECQL5 | oncoprotein | 5 | 0.600 | 1.806 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5) SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding TAtT (PF16811, IPR031823): TRAP transporter T-component |
152 |
RFXAP | interactor | 1 | 0 | 0 | RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain |
153 |
RNF146 | interactor | 5 | 0.667 | 0.244 | WWE (PF02825, IPR004170, SM00678): WWE domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
154 |
RNF2 | interactor | 72 | 0.240 | 671.520 | zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
155 |
RPA1 | suppressor | 48 | 0.470 | 109.542 | Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain |
156 |
RPA2 | oncoprotein | 42 | 0.490 | 76.779 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
157 |
RPA3 | interactor | 38 | 0.494 | 61.142 | Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3 |
158 |
RPL11 | suppressor | 69 | 0.559 | 132.197 | Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5 Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus |
159 |
RPL14 | interactor | 66 | 0.571 | 176.241 | KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14 UPF0688 (PF15772, IPR031530): UPF0688 family |
160 |
RPL15 | interactor | 67 | 0.593 | 99.298 | Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15 |
161 |
RPL18 | interactor | 70 | 0.556 | 149.315 | Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e |
162 |
RPL18A | interactor | 53 | 0.663 | 101.804 | Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A |
163 |
RPL19 | interactor | 59 | 0.643 | 66.271 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e |
164 |
RPL21 | interactor | 53 | 0.728 | 31.253 | Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e |
165 |
RPL24 | interactor | 59 | 0.603 | 115.928 | MAS20 (PF02064, IPR002056): MAS20 protein import receptor Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e |
166 |
RPL3 | interactor | 63 | 0.623 | 99.921 | Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3 |
167 |
RPL4 | interactor | 69 | 0.552 | 195.975 | Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain |
168 |
RPL5 | oncoprotein | 71 | 0.557 | 197.877 | Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18 |
169 |
RPL6 | protein found in more fusions | 78 | 0.498 | 287.362 | Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain |
170 |
RPL7 | interactor | 66 | 0.602 | 102.393 | Ribosomal_L30 (PF00327, IPR016082): Ribosomal protein L30p/L7e Ribosomal_L30_N (PF08079, IPR012988): Ribosomal L30 N-terminal domain |
171 |
RPL7A | protein found in more fusions | 58 | 0.632 | 77.172 | Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family |
172 |
RPL8 | interactor | 65 | 0.585 | 106.898 | Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain |
173 |
RPL9 | interactor | 61 | 0.660 | 50.921 | Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6 |
174 |
RPS16 | interactor | 62 | 0.608 | 100.717 | Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16 |
175 |
RPS19 | interactor | 56 | 0.586 | 118.422 | Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e |
176 |
RPS2 | interactor | 70 | 0.526 | 189.717 | Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain |
177 |
RPS23 | protein found in more fusions | 51 | 0.655 | 66.900 | Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23 |
178 |
RPS24 | protein found in more fusions | 55 | 0.705 | 39.293 | Fascin (PF06268, IPR022768): Fascin domain Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) |
179 |
RPS26 | interactor | 43 | 0.729 | 31.685 | Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e |
180 |
RPS3A | interactor | 77 | 0.509 | 220.622 | Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family |
181 |
RPS4X | interactor | 75 | 0.522 | 195.647 | KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus |
182 |
RPS5 | interactor | 55 | 0.634 | 60.302 | Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e |
183 |
RPS6 | interactor | 74 | 0.520 | 223.656 | Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574) |
184 |
RPS6KB2 | interactor | 22 | 0.506 | 17.364 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
185 |
RPS8 | interactor | 81 | 0.471 | 317.155 | Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e |
186 |
RRP1B | interactor | 24 | 0.493 | 27.360 | Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52 |
187 |
S100A11 | suppressor | 4 | 1.000 | 0 | S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
188 |
SCARNA22 | interactor | 17 | 0.426 | 20.485 | NA |
189 |
SEPT9 | oncoprotein | 7 | 0.667 | 0.379 | Septin (PF00735, IPR000038): Septin DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) |
190 |
SF3B4 | interactor | 16 | 0.450 | 19.808 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
191 |
SIRT7 | interactor | 75 | 0.267 | 636.720 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
192 |
SKI | oncoprotein | 13 | 0.621 | 10.381 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
193 |
SMURF1 | interactor | 30 | 0.352 | 52.920 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
194 |
SP1 | protein found in more fusions | 18 | 0.382 | 39.844 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
195 |
SPG20 | interactor | 4 | 1.000 | 0 | MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein |
196 |
SREK1 | protein found in more fusions | 15 | 0.549 | 8.203 | Ureide_permease (PF07168, IPR009834): Ureide permease RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4 |
197 |
SRPK2 | oncoprotein | 31 | 0.310 | 111.330 | DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) |
198 |
SRPK3 | interactor | 12 | 0.379 | 11.127 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pkinase (PF00069, IPR000719): Protein kinase domain |
199 |
SRSF5 | interactor | 21 | 0.471 | 30.111 | DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term |
200 |
SSB | interactor | 30 | 0.329 | 89.420 | HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif |
201 |
STAU1 | protein found in more fusions | 54 | 0.470 | 162.459 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
202 |
SUPT4H1 | interactor | 6 | 0.600 | 2.186 | Spt4 (PF06093, IPR022800): Spt4/RpoE2 zinc finger |
203 |
SUPT5H | interactor | 21 | 0.410 | 45.653 | KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912) |
204 |
SUPT6H | interactor | 14 | 0.440 | 19.816 | Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SH2_2 (PF14633, IPR000980): SH2 domain HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6 HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6 PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal DLD (PF14878, IPR027999): Death-like domain of SPT6 |
205 |
SUZ12 | oncoprotein | 33 | 0.268 | 136.810 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
206 |
SWAP70 | oncoprotein | 6 | 0.600 | 1.698 | DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641) GrpE (PF01025, IPR000740): GrpE PH (PF00169, IPR001849, SM00233): PH domain CotJB (PF12652, IPR024207): CotJB protein EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
207 |
TAF4 | protein found in more fusions | 10 | 0.472 | 11.386 | TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) |
208 |
TARDBP | interactor | 63 | 0.510 | 135.010 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
209 |
TERF2 | interactor | 29 | 0.246 | 109.284 | Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif |
210 |
TERT | oncoprotein | 10 | 0.444 | 4.821 | RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain |
211 |
TOP1 | oncoprotein | 43 | 0.377 | 133.720 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region |
212 |
TP53 | oncoprotein | 82 | 0.331 | 658.157 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
213 |
U2AF2 | protein found in more fusions | 50 | 0.441 | 125.693 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
214 |
UBC | protein found in more fusions | 63 | 0.301 | 412.634 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
215 |
UBL4A | interactor | 39 | 0.646 | 46.930 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
216 |
UNK | interactor | 14 | 0.319 | 20.164 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
217 |
UQCRC2 | oncoprotein | 9 | 0.500 | 3.573 | Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain |
218 |
USP7 | oncoprotein | 32 | 0.346 | 80.110 | MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal |
219 |
VCAM1 | interactor | 52 | 0.407 | 118.296 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
220 |
VHL | oncoprotein | 40 | 0.409 | 102.124 | Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain |
221 |
WDR43 | interactor | 7 | 0.667 | 0.609 | Utp12 (PF04003, IPR007148): Dip2/Utp12 Family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Zip (PF02535, IPR003689): ZIP Zinc transporter ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
222 |
XRCC5 | suppressor | 51 | 0.256 | 233.078 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like |
223 |
XRCC6 | oncoprotein | 54 | 0.272 | 295.554 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain |
224 |
YWHAQ | interactor | 38 | 0.323 | 135.740 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
225 |
YY1 | protein found in more fusions | 21 | 0.442 | 27.666 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
226 |
ZBTB1 | interactor | 12 | 0.864 | 0.756 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |
227 |
ZFP36 | oncoprotein | 3 | 0.667 | 0.095 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
228 |
ZNF689 | interactor | 2 | 1.000 | 0 | A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger |