Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NAGK (from a repository: Sat Nov 12 09:37:27 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins9 (16.98 %)
The number (and %) of the tumor suppressors5 (9.43 %)
Total number of binary PPIs (saturation %)124 (9.00 %)
The number (and %) of affected PPIs53 (42.74 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.113
Assortativity coefficient-0.5253
The network average Clustering coefficient0.434
The number (and %) of a zero Clustering coefficients21 (39.62 %)
The number (and %) of a zero Betweenness Centrality30 (56.60 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NAGK All fusions
: AW748767;
Proteins found in more fusions TCF12 (see 1 fusions); GNPNAT1 (see 1 fusions); TNNT1 (see 1 fusions); SRPK2 (see 1 fusions); NAGK (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NAGKparental protein530.0432437.771BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
2 ACTR10interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
3 BCCIPinteractor80.8211.638DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
4 C11orf58interactor90.50013.352DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
5 C2orf68interactor100UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
6 C9orf24interactor21.0000SMRP1 (PF15181, IPR028195): Spermatid-specific manchette-related protein 1
7 CCDC158interactor100CCDC158 (PF15921, IPR031809): Coiled-coil domain-containing protein 158
8 CDKN2Csuppressor40.5002.667Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 CHORDC1interactor80.6673.686CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
10 DACH1suppressor200DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508)
Pap_E4 (PF02711, IPR003861): E4 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
11 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
12 DDX19Binteractor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 DDX39Ainteractor50.6672.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
15 FGFR1OPoncoprotein200FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
16 GAS2L1interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
SPX (PF03105, IPR004331): SPX domain
17 GCLMinteractor30.6671.000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
18 GDAinteractor80.7143.852Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
19 GNAI2oncoprotein30.6671.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
20 GNPNAT1protein found in more fusions200Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
21 GRAP2interactor100NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
22 HSPD1suppressor41.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
23 KYNUinteractor80.7862.019Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V
CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
24 LACTB2interactor30.6670.400E2_bind (PF08825, IPR014929): E2 binding domain
Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
25 LDHAinteractor100.58310.586Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
26 LDHAL6Binteractor80.7503.471Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27 LENG1interactor100Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF3323 (PF11796, IPR024466): Protein of unknown function N-terminus (DUF3323)
28 LIMCH1interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
DUF3435 (PF11917, IPR021842): Protein of unknown function (DUF3435)
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
29 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
30 MEOX1interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
31 MTHFD2interactor100THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
32 PKMoncoprotein30.6671.000PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
33 PPHLN1interactor21.0000Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
34 PROSCinteractor31.0000Ala_racemase_N (PF01168, IPR001608): Alanine racemase, N-terminal domain
35 RELoncoprotein40.5002.667RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
36 SCRN1interactor30.6671.000AAT (PF03417, IPR005079): Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Peptidase_C69 (PF03577, IPR005322): Peptidase family C69
37 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
38 SF3B3interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
39 SMAD2suppressor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
40 SMAD9interactor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
41 SMSinteractor130.46230.538Spermine_synth (PF01564, IPR001045): Spermine/spermidine synthase
42 SORDinteractor100.55611.686ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
43 SPRED1interactor100SMC_ScpA (PF02616, IPR003768): Segregation and condensation protein ScpA
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
WH1 (PF00568, IPR000697, SM00461): WH1 domain
44 SRPK2oncoprotein40.6671.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
45 STK16interactor40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
46 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
47 TCF12oncoprotein50.5002.667HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
48 TESsuppressor100LIM (PF00412, IPR001781, SM00132): LIM domain
PET (PF06297, IPR010442): PET Domain
PSCyt3 (PF07627, IPR013039): Protein of unknown function (DUF1588)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
49 TNNT1protein found in more fusions200Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
50 WDR1interactor50.6002.333eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
51 WDR82oncoprotein100MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52 WIPI2interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
53 XPNPEP1interactor100Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

B a c k    t o    T o p ⇑