Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MYOD1 (from a repository: Sun Dec 4 15:09:12 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)68
The number (and %) of the onco-proteins26 (38.24 %)
The number (and %) of the tumor suppressors20 (29.41 %)
Total number of binary PPIs (saturation %)352 (15.45 %)
The number (and %) of affected PPIs68 (19.32 %)
The number of possible different fusions24
PPI diameter2
PPI radius1
The average degree of PPI9.206
Assortativity coefficient-0.2534
The network average Clustering coefficient0.548
The number (and %) of a zero Clustering coefficients6 (8.82 %)
The number (and %) of a zero Betweenness Centrality14 (20.59 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYOD1 All fusions
: BE298077;
Proteins found in more fusions RUNX1 (see 1 fusions); CREBBP (see 6 fusions); STAT3 (see 2 fusions); KAT2B (see 1 fusions); SMAD4 (see 2 fusions); SETD7 (see 2 fusions); HSP90AA1 (see 2 fusions); PRMT5 (see 2 fusions); TCF3 (see 4 fusions); NR2F2 (see 1 fusions); MYOD1 (see 1 fusions); ID3 (see 1 fusions); KAT5 (see 3 fusions); RXRA (see 2 fusions); HUWE1 (see 2 fusions); EZH2 (see 1 fusions); EP300 (see 1 fusions); TSC22D3 (see 2 fusions); DDX5 (see 1 fusions); CREB1 (see 2 fusions); SUV39H1 (see 1 fusions); SP1 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYOD1parental protein680.1112755.616Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Mfp-3 (PF04202, IPR007328): Foot protein 3
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
2 BHLHE40interactor70.5333.633Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
3 BHLHE41suppressor70.4673.976Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX)
Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
4 C2orf88interactor100SmAKAP (PF15127, IPR027969): Small membrane A-kinase anchor protein
5 CARM1oncoprotein80.7144.495K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain
CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
6 CBFBsuppressor21.0000CBF_beta (PF02312, IPR003417): Core binding factor beta subunit
7 CBX1interactor50.8330.222Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
8 CDK4oncoprotein50.7001.150Pkinase (PF00069, IPR000719): Protein kinase domain
9 CDKN1Csuppressor21.0000CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
10 CREB1oncoprotein120.7273.906bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
11 CREBBPsuppressor220.45251.012Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
12 CSRP3interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
13 DDX5oncoprotein100.6943.943DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 ELSPBP1interactor31.0000fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
SH3_6 (PF12913): SH3 domain (SH3b1 type)
15 EP300oncoprotein300.305179.631Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
16 ESR1suppressor230.39477.751Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
17 ESR2suppressor90.7861.897zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
18 EZH2suppressor130.40923.941CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
19 FBXO32suppressor100Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
20 HDAC1suppressor290.272188.460FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
21 HEY1oncoprotein100Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
HTH_Crp_2 (PF13545, IPR012318): Crp-like helix-turn-helix domain
22 HIST1H3Ainteractor170.45832.612Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
23 HSP90AA1oncoprotein150.34144.166HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
24 HUWE1oncoprotein70.4676.133BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
25 ID1interactor50.6002.733HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
26 ID2oncoprotein70.6003.133HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
27 ID3oncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
28 IFRD1interactor40.6670.500IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
29 JUNoncoprotein180.50032.079bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
30 KAT2Bprotein found in more fusions120.5649.971Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
31 KAT5suppressor150.52724.662MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
32 KPNA3interactor30.6670.143Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
33 MDFIinteractor31.0000MDFI (PF15316, IPR026134): MyoD family inhibitor
34 MEF2Concoprotein50.6002.556SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
35 MOSoncoprotein30.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
36 MYOCDinteractor30.6670.333BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
IncA (PF04156, IPR007285): IncA protein
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
37 NCOR1oncoprotein160.50025.299BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
38 NR2F2protein found in more fusions50.6671.000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
39 NUPR1suppressor30.6670.667Phospho_p8 (PF10195, IPR018792): DNA-binding nuclear phosphoprotein p8
40 PABPN1interactor40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Shadoo (PF14999, IPR029238): Shadow of prion protein, neuroprotective
41 PAX7oncoprotein21.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax7 (PF12360, IPR022106): Paired box protein 7
42 PBX1oncoprotein50.8000.800PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
43 PHBsuppressor80.6435.219Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
44 PHB2interactor80.6076.354DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
45 POLR2Ginteractor31.0000SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
46 PPARGC1Ainteractor70.7141.968Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
47 PRMT5protein found in more fusions90.39310.867PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
48 PSMD4interactor50.5004.667UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
49 PSME2interactor200PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
50 RB1suppressor190.32276.550RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
51 RORAinteractor50.4002.883zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
52 RUNX1suppressor110.53312.198Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
53 RXRAoncoprotein110.42215.060zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
54 SETD3interactor100Pertussis_S2S3 (PF02918, IPR020063): Pertussis toxin, subunit 2 and 3, C-terminal domain
Rubis-subs-bind (PF09273, IPR015353): Rubisco LSMT substrate-binding
SET (PF00856, IPR001214, SM00317): SET domain
Transposase_1 (PF01359, IPR001888): Transposase (partial DDE domain)
55 SETD7protein found in more fusions80.6194.182MORN (PF02493, IPR003409, SM00698): MORN repeat
MORN_2 (PF07661, IPR011652): MORN repeat variant
SET (PF00856, IPR001214, SM00317): SET domain
56 SIRT1suppressor220.33876.776DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
57 SMAD4suppressor100.7223.723MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
58 SMAD7interactor60.7331.126MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
59 SMARCA4suppressor210.32985.483DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
60 SMARCD3interactor70.4766.101SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
61 SNW1protein found in more fusions110.44412.608SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
62 SP1protein found in more fusions180.50032.580zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
63 STAT3suppressor150.61514.200SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
64 SUV39H1protein found in more fusions120.43619.517Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
65 TCF3suppressor140.33339.519CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
66 TCF4suppressor60.6003.667CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
67 TRIM27oncoprotein70.5336.667IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
68 TSC22D3protein found in more fusions41.0000TSC22 (PF01166, IPR000580): TSC-22/dip/bun family

B a c k    t o    T o p ⇑