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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MYLIP (from a repository: Mon Dec 5 21:59:15 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins6 (28.57 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)39 (18.57 %)
The number (and %) of affected PPIs21 (53.85 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.571
Assortativity coefficient-0.5018
The network average Clustering coefficient0.351
The number (and %) of a zero Clustering coefficients11 (52.38 %)
The number (and %) of a zero Betweenness Centrality15 (71.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYLIP All fusions
: AA847526;
Proteins found in more fusions KDM1A (see 2 fusions); RASSF5 (see 2 fusions); SRPK2 (see 1 fusions); UBE2D2 (see 2 fusions); MYLIP (see 1 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYLIPparental protein210.037361.000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
2 CNPY2interactor100DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP
3 CRKoncoprotein100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
4 DAPP1interactor100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
5 KDM1Aprotein found in more fusions200Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
6 KRASoncoprotein40.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
7 LDLRinteractor21.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
8 LNX2interactor40.6671.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
9 LRP8interactor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
10 MIPOL1interactor31.0000Bac_globin (PF01152, IPR001486): Bacterial-like globin
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rho_Binding (PF08912, IPR015008): Rho Binding
IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
11 MYL12Binteractor100EF-hand_11 (PF08976, IPR015070): EF-hand domain
EF-hand_6 (PF13405, IPR002048): EF-hand domain
DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
12 RASSF5suppressor31.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
13 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
14 TSC22D4interactor100AflR (PF08493, IPR013700): Aflatoxin regulatory protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
15 UBE2D1interactor40.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
16 UBE2D2oncoprotein40.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
17 UBE2D3interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
18 UBE2D4interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
19 UBE2Nprotein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 USP2interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
21 VLDLRinteractor100EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
DUF4010 (PF13194, IPR025105): Domain of unknown function (DUF4010)
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site

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