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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)76
The number (and %) of the onco-proteins14 (18.42 %)
The number (and %) of the tumor suppressors4 (5.26 %)
Total number of binary PPIs (saturation %)163 (5.72 %)
The number (and %) of affected PPIs75 (46.01 %)
The number of possible different fusions14
PPI diameter3
PPI radius2
The average degree of PPI3.658
Assortativity coefficient-0.2351
The network average Clustering coefficient0.314
The number (and %) of a zero Clustering coefficients33 (43.42 %)
The number (and %) of a zero Betweenness Centrality41 (53.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KXD1,MYH7 All fusions
: N80879;
Proteins found in more fusions AFF1 (see 2 fusions); TPM2/TPM1 (see 1 fusions); ITSN2 (see 1 fusions); TPM2 (see 1 fusions); EWSR1 (see 2 fusions); TPM3 (see 2 fusions); EXOC5 (see 1 fusions); TPM1 (see 2 fusions); PDCD6 (see 1 fusions); TPM2/TPM3 (see 1 fusions); CLINT1 (see 2 fusions); ACTN2 (see 1 fusions); MYH7/KXD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KXD1parental protein440.0273902.752KxDL (PF10241, IPR019371): Uncharacterized conserved protein
2 MYH7parental protein320.0282886.986IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
3 ACTN2protein found in more fusions90.42947.033CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 ACTN3interactor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 AFF1oncoprotein200AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
6 APPL1interactor200ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
7 ARHGDIGinteractor21.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
8 ATP6V1Dinteractor100ATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
9 BORCS6interactor30.33314.464DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
10 C4orf46interactor100RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
11 CCDC185interactor100DUF4659 (PF15558, IPR029090): Domain of unknown function (DUF4659)
12 CCDC33interactor50.4006.000C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
13 CDCA8interactor3016.019Borealin (PF10512, IPR018867): Cell division cycle-associated protein 8
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
14 CEP170P1interactor50.5003.000NA
15 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
16 CEP63interactor40.33340.040DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
17 CLINT1protein found in more fusions50.33347.240ENTH (PF01417, IPR001026, SM00273): ENTH domain
18 CLSPNinteractor100Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
Presenilin (PF01080, IPR001108): Presenilin
PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
19 DISC1interactor90.194142.743HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
20 DTNBP1interactor60.5337.233Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
21 DYRK2interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
22 EWSR1oncoprotein60.20071.310RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 EXOC5protein found in more fusions50.50041.052Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
24 EXOC7interactor50.60019.398Exo70 (PF03081, IPR004140): Exo70 exocyst complex subunit
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
25 FAM58Ainteractor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
26 FXR2interactor60.40010.452Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
27 GABARAPL1interactor40.50038.611Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
28 HAUS1interactor70.40011.095THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
29 IFT20interactor50.60018.169IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
30 ING5suppressor21.0000ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
31 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
32 KEAP1oncoprotein50.33347.240BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
33 KIAA0368interactor30.6672.352HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
34 KRT81interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
35 LIMS1interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
36 LMO3oncoprotein30.6671.000LIM (PF00412, IPR001781, SM00132): LIM domain
37 LNX1interactor200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
38 LRRC45interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NBP1 (PF08537, IPR013743): Fungal Nap binding protein NBP1
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
39 MAP1LC3Ainteractor60.40070.094Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
40 MAP1LC3Binteractor40.50038.611Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
41 MCRS1interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
42 MOB1Asuppressor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
43 NIF3L1interactor40.33326.457NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
44 NTHL1interactor100HhH-GPD (PF00730, IPR003265): HhH-GPD superfamily base excision DNA repair protein
45 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
46 PDCD6oncoprotein31.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
47 POLD1interactor100DNA_pol_B (PF00136, IPR006134): DNA polymerase family B
DNA_pol_B_exo1 (PF03104, IPR006133): DNA polymerase family B, exonuclease domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
48 PPP3R1interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49 PRDX5interactor21.0000Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
50 PSMC3interactor40.33327.817AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
51 PSMD4interactor40.16745.555UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
52 RABGEF1interactor200Rho_Binding (PF08912, IPR015008): Rho Binding
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein
53 RBPJinteractor30.6677.383BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
54 RNF183interactor21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
55 ROGDIinteractor21.0000Rogdi_lz (PF10259, IPR028241): Rogdi leucine zipper containing protein
56 RPL9interactor100Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
57 SEC61Binteractor3024.667Sec61_beta (PF03911, IPR016482): Sec61beta family
58 SIRT6suppressor100SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
59 SIX1oncoprotein100KilA-N (PF04383, IPR018004): KilA-N domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
60 SPTAN1oncoprotein50.30046.624EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
61 STX11interactor60.4007.500KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
62 TAF11interactor100CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
TAFII28 (PF04719, IPR006809): hTAFII28-like protein conserved region
63 TARSL2interactor100HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
64 TCEA2interactor100Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
65 TCEB3Binteractor100Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
FAM176 (PF14851): FAM176 family
66 TMEM260interactor100DUF2723 (PF11028, IPR021280): Protein of unknown function (DUF2723)
PMT_2 (PF13231): Dolichyl-phosphate-mannose-protein mannosyltransferase
67 TNNI1interactor40.8337.383Troponin (PF00992, IPR001978): Troponin
68 TPM1protein found in more fusions80.381150.452Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
69 TPM2protein found in more fusions70.60025.016DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
70 TPM3oncoprotein50.66747.333Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
71 UTP6interactor100NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6
TPR_14 (PF13428): Tetratricopeptide repeat
72 WWOXsuppressor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
73 YWHAQinteractor60.33350.91814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
74 ZBTB25interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
75 ZC4H2interactor100zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
76 ZNF417interactor21.0000A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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