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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MYBL2 (from a repository: Sat Nov 12 09:36:39 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins13 (29.55 %)
The number (and %) of the tumor suppressors13 (29.55 %)
Total number of binary PPIs (saturation %)136 (14.38 %)
The number (and %) of affected PPIs44 (32.35 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.455
Assortativity coefficient-0.4366
The network average Clustering coefficient0.506
The number (and %) of a zero Clustering coefficients12 (27.27 %)
The number (and %) of a zero Betweenness Centrality19 (43.18 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYBL2 All fusions
: BE264624; BE252428; AW246196; BE264691;
Proteins found in more fusions CREBBP (see 5 fusions); MYBL2 (see 4 fusions); NLK (see 4 fusions); EWSR1 (see 2 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); LZTR1 (see 2 fusions); HIPK2 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYBL2parental protein440.0851436.400Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
2 CCNA1interactor50.9000.333Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
3 CCNE1oncoprotein70.7142.567Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CCNFoncoprotein100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
5 CCNT1oncoprotein31.0000Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
MDFI (PF15316, IPR026134): MyoD family inhibitor
6 CDK2suppressor170.35061.100Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
7 CDK9protein found in more fusions40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
8 CDKN1Csuppressor40.8330.333CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
9 CLTAinteractor50.7003.000Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
10 CLTConcoprotein50.8001.333Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
11 CREBBPsuppressor130.39429.967Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
12 CTDSPL2interactor100NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
13 CXCR4interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
14 E2F1suppressor100.57810.933Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
15 E2F3suppressor30.6670.400E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
16 EP300oncoprotein100.55610.667Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
17 EWSR1oncoprotein70.5334.400RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FLNAsuppressor50.8001.333CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
19 FOXM1oncoprotein70.6194.567EspF (PF04806, IPR006891): EspF protein repeat
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
20 HIPK2suppressor50.8330.500Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
21 LIN37interactor90.55610.300LIN37 (PF15306, IPR028226): LIN37
22 LIN52interactor51.0000LIN52 (PF10044, IPR018737): Retinal tissue protein
23 LIN54interactor70.7622.133TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
24 LIN9suppressor90.6078.133DIRP (PF06584, IPR010561, SM01135): DIRP
Rotavirus_VP1 (PF12289, IPR022071): Rotavirus VP1 C-terminal domain
FTA4 (PF13093, IPR025207): Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
25 LZTR1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
26 MAP1LC3Binteractor21.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
27 MAPK6oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
28 NLKprotein found in more fusions50.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
29 NUF2interactor100Nuf2 (PF03800, IPR005549): Nuf2 family
DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
30 PARP1suppressor90.53611.833BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
31 PLA2G4Aoncoprotein100C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
32 PPP2R3Cinteractor100DUF61 (PF01886, IPR002746): Protein of unknown function DUF61
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
33 RBBP4oncoprotein70.6195.567eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
34 RBL1suppressor110.36427.900RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
35 SKP2suppressor90.44414.967LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
36 SPTA1interactor100EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
37 SPTBN1suppressor40.6671.333CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
38 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
39 TRIM15suppressor200Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
40 TTF2interactor100SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
zf-GRF (PF06839, IPR010666): GRF zinc finger
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
41 UBE2D4interactor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 ZBTB9interactor21.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
PRIMA1 (PF16101): Proline-rich membrane anchor 1
43 ZNF622interactor200S-antigen (PF05756, IPR008825): S-antigen protein
Stm1_N (PF09598, IPR019084): Stm1
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
44 ZSCAN26interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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