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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MTMR9 (from a repository: Mon Nov 14 04:11:17 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins7 (43.75 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)38 (31.67 %)
The number (and %) of affected PPIs16 (42.11 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.375
Assortativity coefficient-0.4300
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients4 (25.00 %)
The number (and %) of a zero Betweenness Centrality9 (56.25 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: MTMR9 All fusions
: AW409328;
Proteins found in more fusions EWSR1 (see 2 fusions); KDM1A (see 2 fusions); CUL3 (see 1 fusions); MTMR9 (see 1 fusions); EMILIN1 (see 2 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MTMR9parental protein160.114170.333Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
2 CUL3protein found in more fusions50.6671.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
3 ELAVL1oncoprotein60.5004.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 EMILIN1protein found in more fusions31.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
IncA (PF04156, IPR007285): IncA protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Unstab_antitox (PF09720, IPR013406): Putative addiction module component
DUF2802 (PF10975, IPR021244): Protein of unknown function (DUF2802)
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
5 EWSR1oncoprotein41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 KCTD17interactor50.5002.667BTB_2 (PF02214, IPR003131): BTB/POZ domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
7 KDM1Aprotein found in more fusions31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
8 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
9 MOSoncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
10 MTMR6interactor40.5002.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
11 MTMR7interactor200DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
12 MTMR8interactor100Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
13 NMIinteractor50.5003.000IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
14 SPG21interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
15 VAC14oncoprotein31.0000TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
16 XPO1interactor30.6671.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)AW409328
2 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
AW409328
3 KDM1AinteractorAmino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
AW409328
4 LNX1interactorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
AW409328
5 MOSoncoproteinPkinase (PF00069, IPR000719): Protein kinase domainAW409328
6 MTMR9parental proteinMyotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
AW409328
7 SPG21interactorAbhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase foldAW409328

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