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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins13 (22.81 %)
The number (and %) of the tumor suppressors5 (8.77 %)
Total number of binary PPIs (saturation %)259 (16.23 %)
The number (and %) of affected PPIs59 (22.78 %)
The number of possible different fusions4
PPI diameter3
PPI radius2
The average degree of PPI8.702
Assortativity coefficient-0.2017
The network average Clustering coefficient0.421
The number (and %) of a zero Clustering coefficients13 (22.81 %)
The number (and %) of a zero Betweenness Centrality13 (22.81 %)


List of the fusions

PPI for parental proteins: MT-CO2,MT-CO1 All fusions
Proteins found in more fusions EGFR (see 2 fusions); CUL7 (see 2 fusions); PRDX4 (see 1 fusions); BCAP31 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MT-CO2parental protein430.1851462.790COX2 (PF00116, IPR002429): Cytochrome C oxidase subunit II, periplasmic domain
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
2 MT-CO1parental protein170.044744.841DUF3485 (PF11984, IPR014263): Protein of unknown function (DUF3485)
3 ASGR2interactor100UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
4 ATP2B3interactor30.6670.400Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 ATP5C1interactor150.60020.291ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
6 ATP5F1interactor150.324143.123Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
7 BCAP31protein found in more fusions80.7621.786Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
8 CANXinteractor120.50023.227Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
9 CDC42oncoprotein40.33310.936Ras (PF00071, IPR001806, SM00173): Ras family
10 CDK2suppressor110.51113.231Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CLEC4Ginteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
12 CLTConcoprotein170.52932.391Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
13 COX14interactor100COX14 (PF14880, IPR029208): Cytochrome oxidase c assembly
14 COX20interactor100DUF3767 (PF12597, IPR022533): Protein of unknown function (DUF3767)
15 COX4I1interactor160.442115.502COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
16 COX5Binteractor21.0000COX5B (PF01215, IPR002124): Cytochrome c oxidase subunit Vb
17 CUL7protein found in more fusions100.47217.662ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
18 DDOSTinteractor190.51540.349DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
19 ECT2suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
20 EDNRAinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
21 EGFRoncoprotein130.45524.807Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 FAF2interactor100.44415.904DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
23 FAM134Cinteractor203.554Reticulon (PF02453, IPR003388): Reticulon
24 FN1oncoprotein100.55613.388fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
25 GPD2interactor40.5002.067DAO (PF01266, IPR006076): FAD dependent oxidoreductase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
DAO_C (PF16901, IPR031656): C-terminal domain of alpha-glycerophosphate oxidase
26 GPR52interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
27 HSP90B1suppressor110.6188.867CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
28 HSPB2interactor40.6672.794Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
29 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
30 MAGT1interactor80.7861.536OST3_OST6 (PF04756, IPR021149): OST3 / OST6 family, transporter family
31 MEOX2interactor208.948Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
32 MRPL58interactor120.50067.720RF-1 (PF00472, IPR000352): RF-1 domain
33 NDUFB8interactor70.42931.442NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
34 NDUFS1interactor110.52718.011NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
35 NDUFV2interactor50.7001.8002Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
36 NELFCDoncoprotein30.6671.222TH1 (PF04858, IPR006942): TH1 protein
37 NLGN3interactor30.33334.433COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
38 P2RY12interactor203.5547tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
39 PHBsuppressor160.47539.919Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
40 PRDX4protein found in more fusions304.500AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
41 PSMA1interactor200Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
42 RAB1Boncoprotein60.60014.793Ras (PF00071, IPR001806, SM00173): Ras family
43 RAD21oncoprotein100Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
44 RIDAinteractor200Ribonuc_L-PSP (PF01042, IPR006175): Endoribonuclease L-PSP
45 RPN1oncoprotein180.48446.807Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
46 SDHBsuppressor90.47216.443Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
47 SLC25A3interactor150.41944.489Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
48 SNCAinteractor80.38130.439Synuclein (PF01387, IPR001058): Synuclein
49 SSR1interactor100.6679.059TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
50 SSR4interactor120.48525.942TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
51 UQCRBinteractor90.41734.289UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
52 UQCRC2oncoprotein230.364145.307Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
53 VDAC1interactor170.52938.624Porin_3 (PF01459, IPR027246): Eukaryotic porin
54 VDAC2interactor180.47752.571Porin_3 (PF01459, IPR027246): Eukaryotic porin
55 VDAC3interactor190.43961.110Porin_3 (PF01459, IPR027246): Eukaryotic porin
56 YME1L1interactor41.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
57 YWHAEoncoprotein50.7001.13314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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