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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors2 (14.29 %)
Total number of binary PPIs (saturation %)34 (37.36 %)
The number (and %) of affected PPIs14 (41.18 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.286
Assortativity coefficient-0.5030
The network average Clustering coefficient0.581
The number (and %) of a zero Clustering coefficients4 (28.57 %)
The number (and %) of a zero Betweenness Centrality9 (64.29 %)


List of the fusions

PPI for parental proteins: MSX1 All fusions
: BU624994;
Proteins found in more fusions MSX1 (see 1 fusions); CREBBP (see 6 fusions); SP1 (see 1 fusions); TLE2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MSX1parental protein140.128130.667Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
2 CREBBPsuppressor41.0000Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
3 DLX2interactor50.8330.667Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
4 DLX5interactor50.8330.667Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
5 HOXC8interactor31.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
6 ING4suppressor200PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
7 LHX2interactor100DUF1314 (PF07013, IPR010741): Protein of unknown function (DUF1314)
LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
8 MED19interactor200Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
9 MSX2interactor50.6672.000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 NMNAT1interactor200CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
11 PAX3oncoprotein21.0000PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax7 (PF12360, IPR022106): Paired box protein 7
12 SP1protein found in more fusions41.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
13 TBPinteractor50.6672.000TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
14 TLE2protein found in more fusions31.0000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain

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