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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins11 (18.33 %)
The number (and %) of the tumor suppressors3 (5.00 %)
Total number of binary PPIs (saturation %)387 (21.86 %)
The number (and %) of affected PPIs60 (15.50 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI12.500
Assortativity coefficient-0.3299
The network average Clustering coefficient0.614
The number (and %) of a zero Clustering coefficients7 (11.67 %)
The number (and %) of a zero Betweenness Centrality14 (23.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MRPL12 All fusions
: AI761218;
Proteins found in more fusions HNRNPD (see 1 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MRPL12 (see 1 fusions); RPLP2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MRPL12parental protein600.1851838.538Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
2 ACOX1interactor100ACOX (PF01756, IPR002655): Acyl-CoA oxidase
Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_ox_N (PF14749, IPR029320): Acyl-coenzyme A oxidase N-terminal
3 ADRB2interactor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AK2interactor21.0000ADK (PF00406, IPR000850): Adenylate kinase
AAA_33 (PF13671): AAA domain
5 BTRConcoprotein100.5567.309WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 C1QBPinteractor190.42754.279MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
7 CAND1interactor310.372140.130Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
8 COX6A2interactor100COX6A (PF02046, IPR001349): Cytochrome c oxidase subunit VIa
9 CUL1oncoprotein220.52940.836Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
10 CUL3protein found in more fusions300.377152.639Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 EPPK1interactor31.0000DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HupF_HypC (PF01455, IPR001109): HupF/HypC family
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal
12 GADD45GIP1oncoprotein90.9720.167CR6_interact (PF10147, IPR018472): Growth arrest and DNA-damage-inducible proteins-interacting protein 1
13 HNRNPDoncoprotein80.7621.633CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
14 ILF3oncoprotein240.46767.548dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
15 MLLT1oncoprotein21.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
16 MRPL1interactor190.57926.622CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
17 MRPL10interactor140.7694.388Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
18 MRPL11interactor150.65711.610Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
19 MRPL15interactor160.60815.431Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
20 MRPL23interactor150.65714.993Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
21 MRPL3interactor180.64715.927Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
22 MRPL37interactor160.67511.571PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
23 MRPL41interactor180.57522.493MRP-L27 (PF09809, IPR019189): Mitochondrial ribosomal protein L27
24 MRPL42interactor150.68610.703MRP-S32 (PF10210, IPR019346): Mitochondrial 28S ribosomal protein S32
25 MRPL47interactor160.7508.984MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
26 MRPL50interactor190.60828.352Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
27 MRPL52interactor110.7453.810SDP_N (PF12278, IPR022063): Sex determination protein N terminal
28 MRPL58interactor240.47170.344RF-1 (PF00472, IPR000352): RF-1 domain
29 MRPL9interactor190.66116.028Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
30 MRPS26interactor110.6366.990MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
31 MRPS27interactor120.5619.756MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
32 MRPS28interactor100.6676.075MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
33 MRPS30interactor180.68612.882PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
34 MRPS9interactor140.60410.763Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
35 NIT2suppressor30.6671.000CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
36 NPM1oncoprotein220.48151.517Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
37 OLIG1interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
38 PARK2suppressor120.6008.421IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
39 PITRM1interactor21.0000M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
40 POLR1Dinteractor100RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
41 RARGinteractor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
42 RBM3interactor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 RNASET2oncoprotein30.6671.000Ribonuclease_T2 (PF00445, IPR001568): Ribonuclease T2 family
DHODB_Fe-S_bind (PF10418, IPR019480): Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B
44 RPL11suppressor150.9051.675Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
45 RPL12interactor170.69923.535Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
46 RPL14interactor160.8088.138KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
47 RPL18interactor140.9231.166Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
48 RPL19interactor150.9051.675DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
49 RPL23interactor150.8386.123Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
50 RPL7Ainteractor150.7627.445Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
51 RPLP2protein found in more fusions130.9700.297Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
52 RPS2interactor210.58136.705Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
53 SOX2oncoprotein90.5363.678HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
54 SRRM2interactor70.7622.810cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
55 SUCLA2interactor30.6671.000ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
nsp7 (PF08716, IPR014828): nsp7 replicase
56 SUCLG2interactor50.5005.000ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
57 TARDBPinteractor170.67518.017RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
58 TMEM9interactor100Tmemb_9 (PF05434, IPR008853): TMEM9
59 UFM1interactor100Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
60 XRCC1interactor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
SPX (PF03105, IPR004331): SPX domain
XRCC1_N (PF01834, IPR002706): XRCC1 N terminal domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain

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