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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins13 (21.67 %)
The number (and %) of the tumor suppressors7 (11.67 %)
Total number of binary PPIs (saturation %)136 (7.68 %)
The number (and %) of affected PPIs60 (44.12 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI4.033
Assortativity coefficient-0.4877
The network average Clustering coefficient0.370
The number (and %) of a zero Clustering coefficients24 (40.00 %)
The number (and %) of a zero Betweenness Centrality33 (55.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MPHOSPH8 All fusions
: BM674866; BU736580; BI858901; BM717590; AI857307;
Proteins found in more fusions SH3BP4 (see 2 fusions); MPHOSPH8 (see 5 fusions); FAM208B (see 2 fusions); NCOA5 (see 1 fusions); KHDRBS1 (see 1 fusions); HECW1 (see 1 fusions); HCFC1 (see 2 fusions); RANBP9 (see 2 fusions); EHMT1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MPHOSPH8parental protein600.0363121.456Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
2 ANKLE2interactor100Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
3 BMI1oncoprotein120.25527.833zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 BRPF1interactor21.0000Pap_E4 (PF02711, IPR003861): E4 protein
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
5 DDX28interactor30.6670.333DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
6 DNMT3Asuppressor40.6672.000DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
7 DYNLRB1interactor21.0000Robl_LC7 (PF03259, IPR004942, SM00960): Roadblock/LC7 domain
8 EHMT1oncoprotein50.6672.000Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
Zip (PF02535, IPR003689): ZIP Zinc transporter
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
9 ENO1oncoprotein30.6670.667Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
10 ERCC6oncoprotein21.0000Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 ESYT2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
12 FAM208Ainteractor40.5000.889DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
13 FAM208Bprotein found in more fusions31.0000DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
14 FBXL6interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
15 HCFC1protein found in more fusions200fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
16 HECW1protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
17 HIST1H2BGoncoprotein40.5002.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HIST1H3Ainteractor80.33314.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 IFI16suppressor90.27820.833HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
20 ILF3oncoprotein60.4005.622dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
21 IMP3interactor100Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
22 KHDRBS1protein found in more fusions40.6670.222KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
23 LRWD1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
24 MATR3interactor120.20030.167DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
25 MB21D1interactor100Mab-21 (PF03281, IPR024810): Mab-21 protein
26 MCRIP2interactor21.0000DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
FAM195 (PF14799, IPR029428): FAM195 family
27 MOV10interactor90.22221.000AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
28 MRPL18interactor40.5002.333Ribosomal_L18p (PF00861, IPR005484): Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
29 MRPS12interactor100Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
30 MTRNR2L1interactor100Humanin (PF15040, IPR028139): Humanin family
31 NCOA5suppressor60.5001.622Macoilin (PF09726, IPR019130): Transmembrane protein
32 NOP2interactor21.0000BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
P120R (PF08062, IPR012586): P120R (NUC006) repeat
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477)
FAM176 (PF14851): FAM176 family
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
33 NUMA1oncoprotein70.3817.622Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
34 NXF1interactor100.38916.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
35 PHIPoncoprotein30.6671.000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
E7 (PF00527, IPR000148): E7 protein, Early protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
36 PPHLN1interactor70.3817.956Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
37 RANBP9suppressor200Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
38 RPL24interactor40.6672.000MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
39 RPL36interactor31.0000Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
40 RPP25Linteractor100Alba (PF01918, IPR002775): Alba
41 RPS11interactor40.6672.000Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
42 SAFBsuppressor40.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
43 SAFB2suppressor50.5002.889LicD (PF04991, IPR007074): LicD family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
44 SH3BP4protein found in more fusions200SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
45 SIRT1suppressor40.6671.000DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
46 SPIRE2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
KIND (PF16474, IPR011019, SM00750): Kinase non-catalytic C-lobe domain
47 TBC1D4interactor100DUF632 (PF04782, IPR006867): Protein of unknown function (DUF632)
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
RecR (PF02132, IPR023628): RecR protein
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
DUF4806 (PF16064, IPR032071): Domain of unknown function (DUF4806)
48 TMEM33interactor100UPF0121 (PF03661, IPR005344): Uncharacterised protein family (UPF0121)
49 TRRAPinteractor100BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
50 TSR3interactor100DUF367 (PF04034, IPR007177): Domain of unknown function (DUF367)
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
51 UBTFinteractor21.0000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
52 USMG5interactor100ATP_synth_reg (PF14960): ATP synthase regulation
53 UTP23interactor100Fcf1 (PF04900, IPR006984): Fcf1
54 YIPF5interactor100Yip1 (PF04893, IPR006977): Yip1 domain
55 ZEB1interactor21.0000CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
GET2 (PF08690, IPR028143): GET complex subunit GET2
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
56 ZNF121interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
57 ZNF597interactor40.6671.000zf-RING_7 (PF02591, IPR003743): C4-type zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)
58 ZNF638interactor40.5000.889RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-met (PF12874): Zinc-finger of C2H2 type
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
59 ZNF770interactor100IL3 (PF02059, IPR002183): Interleukin-3
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)
60 ZNF845interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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