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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MLX (from a repository: Sat Nov 12 16:40:13 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins6 (40.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)28 (26.67 %)
The number (and %) of affected PPIs15 (53.57 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.800
Assortativity coefficient-0.4972
The network average Clustering coefficient0.394
The number (and %) of a zero Clustering coefficients7 (46.67 %)
The number (and %) of a zero Betweenness Centrality11 (73.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MLX All fusions
Proteins found in more fusions MLX (see 1 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); AES (see 3 fusions); ID3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MLXparental protein150.077161.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3322 (PF11795, IPR024537): Uncharacterized protein conserved in bacteria N-term (DUF3322)
2 AESprotein found in more fusions200TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 APPprotein found in more fusions50.5003.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 EWSR1oncoprotein31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
5 GABARAPL2interactor21.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
6 ID3oncoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
7 MLXIPinteractor100ZapB (PF06005, IPR009252): Cell division protein ZapB
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Stm1_N (PF09598, IPR019084): Stm1
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
8 MLXIPLinteractor100ZapB (PF06005, IPR009252): Cell division protein ZapB
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
9 MNTsuppressor200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Sipho_Gp157 (PF05565, IPR008840): Siphovirus Gp157
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 MXD1oncoprotein21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
11 MXD4interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
12 NXF1interactor41.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
13 RBM39oncoprotein40.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
14 SAP30BPinteractor40.6672.000Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HCNGP (PF07818, IPR012479): HCNGP-like protein
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
15 ZBTB32interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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