Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins MLX (from a repository: Sat Nov 12 16:40:13 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 15 The number (and %) of the onco-proteins 6 (40.00 %) The number (and %) of the tumor suppressors 1 (6.67 %) Total number of binary PPIs (saturation %) 28 (26.67 %) The number (and %) of affected PPIs 15 (53.57 %) The number of possible different fusions 6 PPI diameter 2 PPI radius 1 The average degree of PPI 2.800 Assortativity coefficient -0.4972 The network average Clustering coefficient 0.394 The number (and %) of a zero Clustering coefficients 7 (46.67 %) The number (and %) of a zero Betweenness Centrality 11 (73.33 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MLX	All fusions
Proteins found in more fusions	MLX (see 1 fusions); EWSR1 (see 2 fusions); APP (see 4 fusions); AES (see 3 fusions); ID3 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MLX	parental protein	15	0.077	161.000	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3322 (PF11795, IPR024537): Uncharacterized protein conserved in bacteria N-term (DUF3322)
2	AES	protein found in more fusions	2	0	0	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3	APP	protein found in more fusions	5	0.500	3.000	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4	EWSR1	oncoprotein	3	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
5	GABARAPL2	interactor	2	1.000	0	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
6	ID3	oncoprotein	2	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
7	MLXIP	interactor	1	0	0	ZapB (PF06005, IPR009252): Cell division protein ZapB HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Stm1_N (PF09598, IPR019084): Stm1 Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
8	MLXIPL	interactor	1	0	0	ZapB (PF06005, IPR009252): Cell division protein ZapB HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
9	MNT	suppressor	2	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Sipho_Gp157 (PF05565, IPR008840): Siphovirus Gp157 DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) PRIMA1 (PF16101): Proline-rich membrane anchor 1
10	MXD1	oncoprotein	2	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
11	MXD4	interactor	1	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
12	NXF1	interactor	4	1.000	0	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
13	RBM39	oncoprotein	4	0.667	2.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
14	SAP30BP	interactor	4	0.667	2.000	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HCNGP (PF07818, IPR012479): HCNGP-like protein Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
15	ZBTB32	interactor	1	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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