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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MIPOL1 (from a repository: Sat Nov 17 13:32:56 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins6 (15.79 %)
The number (and %) of the tumor suppressors4 (10.53 %)
Total number of binary PPIs (saturation %)63 (8.96 %)
The number (and %) of affected PPIs38 (60.32 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.789
Assortativity coefficient-0.5366
The network average Clustering coefficient0.477
The number (and %) of a zero Clustering coefficients17 (44.74 %)
The number (and %) of a zero Betweenness Centrality33 (86.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MIPOL1 All fusions
Proteins found in more fusions MCM7 (see 2 fusions); SRPK2 (see 1 fusions); MYLIP (see 1 fusions); USH1C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MIPOL1parental protein380.0241273.000Bac_globin (PF01152, IPR001486): Bacterial-like globin
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rho_Binding (PF08912, IPR015008): Rho Binding
IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
2 ARNT2interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
3 ATP5Ointeractor100OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
4 BEX2suppressor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
5 BYSLinteractor21.0000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
6 CCDC33interactor80.28620.000C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
7 CCT3interactor21.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CKS1Boncoprotein200CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
10 DGCR6interactor50.5005.000DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
11 DIEXFinteractor100UTP25 (PF06862, IPR010678): Utp25, U3 small nucleolar RNA-associated SSU processome protein 25
eIF-3c_N (PF05470, IPR008905): Eukaryotic translation initiation factor 3 subunit 8 N-terminus
SDA1 (PF05285, IPR007949): SDA1
12 EAF1suppressor21.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
13 EIF4E2interactor100IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
14 ENKD1interactor21.0000Enkurin (PF13864, IPR027012): Calmodulin-binding
15 FAM161Ainteractor31.0000YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
16 FBF1interactor21.0000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
17 HAUS1interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
18 LATS2suppressor40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
19 LRRC39interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
20 MAGEA6interactor30.6671.000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
21 MCM7protein found in more fusions31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
22 MFAP1interactor100MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
23 MYLIPprotein found in more fusions31.0000FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 NEBLinteractor100Bac_small_YrzI (PF09501, IPR012655): Probable sporulation protein (Bac_small_yrzI)
Annexin (PF00191, IPR018502, SM00335): Annexin
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
25 PPP1R13Binteractor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
IncA (PF04156, IPR007285): IncA protein
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
26 PRPF31interactor200Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
27 RBM41interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
28 RCOR3interactor21.0000ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
29 RTP5interactor100zf-3CxxC (PF13695, IPR027377): Zinc-binding domain
30 SCNM1interactor21.0000zf-SCNM1 (PF15803, IPR031622): Zinc-finger of sodium channel modifier 1
SCNM1_acidic (PF15805, IPR031625): Acidic C-terminal region of sodium channel modifier 1 SCNM1
31 SMARCE1interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
32 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
33 SSX3interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
34 TCHPsuppressor21.0000TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
TPH (PF13868): Trichohyalin-plectin-homology domain
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
35 TTC12interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
36 UBE2Kinteractor100UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 USH1Cprotein found in more fusions200CemA (PF03040, IPR004282): CemA family
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Saw1 (PF11561, IPR021624): Single strand annealing-weakened 1
DUF3393 (PF11873, IPR024570): Domain of unknown function (DUF3393)
DUF3567 (PF12091, IPR021951): Protein of unknown function (DUF3567)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
38 ZGPATinteractor21.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
G-patch (PF01585, IPR000467, SM00443): G-patch domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167

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