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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MFN2 (from a repository: Mon Dec 5 22:05:43 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors2 (18.18 %)
Total number of binary PPIs (saturation %)28 (50.91 %)
The number (and %) of affected PPIs11 (39.29 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.273
Assortativity coefficient-0.1928
The network average Clustering coefficient0.728
The number (and %) of a zero Clustering coefficients1 (9.09 %)
The number (and %) of a zero Betweenness Centrality7 (63.64 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MFN2 All fusions
: BF689364; BF834721;
Proteins found in more fusions HUWE1 (see 2 fusions); MAPK9 (see 3 fusions); MFN2 (see 2 fusions); UBE2N (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MFN2parental protein110.17867.000Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
2 HDAC6oncoprotein40.6671.000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
3 HUWE1oncoprotein31.0000BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
4 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
5 MARCH5interactor60.5005.000DUF2517 (PF10725, IPR019663): Protein of unknown function (DUF2517)
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
6 MAVSinteractor31.0000Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
7 NTRK1oncoprotein40.6671.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
8 NXF1interactor31.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
9 PARK2suppressor41.0000IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
10 SLC25A38interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
TRAPP (PF04051, IPR007194): Transport protein particle (TRAPP) component
11 UBE2Nprotein found in more fusions41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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