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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)63
The number (and %) of the onco-proteins11 (17.46 %)
The number (and %) of the tumor suppressors12 (19.05 %)
Total number of binary PPIs (saturation %)643 (32.92 %)
The number (and %) of affected PPIs63 (9.80 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI19.492
Assortativity coefficient-0.0592
The network average Clustering coefficient0.698
The number (and %) of a zero Clustering coefficients2 (3.17 %)
The number (and %) of a zero Betweenness Centrality7 (11.11 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MED21 All fusions
: AA662056;
Proteins found in more fusions VDR (see 2 fusions); MED21 (see 1 fusions); SMARCB1 (see 12 fusions); CREBBP (see 6 fusions); KAT2B (see 1 fusions); HTT (see 1 fusions); POLR2A (see 2 fusions); THRA (see 3 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MED21parental protein630.2921481.540Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
2 BLOC1S6interactor31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
3 BRCA1suppressor160.49522.929BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
4 CCNCsuppressor290.79319.199Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
5 CDK7oncoprotein90.6434.422Pkinase (PF00069, IPR000719): Protein kinase domain
6 CDK8interactor380.61492.816Pkinase (PF00069, IPR000719): Protein kinase domain
7 CREBBPsuppressor200.40445.116Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
8 CSNK2A2interactor60.8000.622Pkinase (PF00069, IPR000719): Protein kinase domain
9 ELAVL1oncoprotein140.42330.131RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 ESR1suppressor280.54467.750Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
11 ESR2suppressor190.8693.880zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ERbeta_N (PF12497, IPR021064): Estrogen receptor beta
12 FBXW7suppressor270.80617.697Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
13 GTF2Binteractor110.47312.363Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
14 GTF2E1interactor100.48916.283DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
15 GTF2F1interactor120.53017.454TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
16 GTF2H4interactor80.7502.350Tfb2 (PF03849, IPR004598): Transcription factor Tfb2
17 HNF4Asuppressor160.64810.038zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18 HTTprotein found in more fusions70.5335.833HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
19 KAT2Bprotein found in more fusions90.7502.900Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
20 MAGEB4interactor100MAGE (PF01454, IPR002190): MAGE family
Pap_E4 (PF02711, IPR003861): E4 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
21 MED1interactor390.64754.321Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
22 MED10interactor310.81312.763Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
23 MED11interactor230.9680.712Med11 (PF10280, IPR019404): Mediator complex protein
24 MED12oncoprotein330.75224.481Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877)
Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain
Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
25 MED13oncoprotein270.8606.780Med13_C (PF06333, IPR009401): Mediator complex subunit 13 C-terminal
Med13_N (PF11597, IPR021643): Mediator complex subunit 13 N-terminal
26 MED14interactor320.75020.840Med14 (PF08638, IPR013947): Mediator complex subunit MED14
27 MED16interactor330.73926.582WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Med16 (PF11635, IPR021665): Mediator complex subunit 16
28 MED17oncoprotein350.70438.952Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
29 MED18interactor260.9322.386Med18 (PF09637, IPR019095): Med18 protein
30 MED19interactor300.8825.576Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
31 MED20interactor330.70840.235Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
32 MED22interactor220.9005.135Med22 (PF06179, IPR009332): Surfeit locus protein 5 subunit 22 of Mediator complex
33 MED23interactor360.65161.071Med23 (PF11573, IPR021629): Mediator complex subunit 23
34 MED24interactor330.75423.636Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
35 MED26interactor290.8557.996Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
36 MED28interactor310.83712.712cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
37 MED29interactor300.8825.576Med29 (PF11568, IPR021018): Mediator complex subunit 29
38 MED30interactor300.82818.274Med30 (PF11315, IPR021019): Mediator complex subunit 30
39 MED4interactor360.64474.491Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
40 MED6interactor340.69549.317Med6 (PF04934, IPR007018): MED6 mediator sub complex component
Peptidase_M15 (PF01427, IPR000755): D-ala-D-ala dipeptidase
41 MED7interactor320.71458.474Med7 (PF05983, IPR009244): MED7 protein
DotU (PF09850, IPR017732): Type VI secretion system protein DotU
42 MED8interactor270.8957.481Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
43 MED9interactor290.8626.623Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
44 PCBD2interactor50.7001.667Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
45 POLR2Aprotein found in more fusions290.442109.719RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
46 POLR2Ginteractor210.71616.304SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
47 PPARGC1Ainteractor150.61017.696Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RSRP (PF17069): Arginine/Serine-Rich protein 1
48 RACGAP1interactor21.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
49 SKP1oncoprotein80.5713.407Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
50 SMARCB1suppressor80.9050.500SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
51 SREBF1interactor160.8293.641HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
52 SSC5Dinteractor100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
53 TARBP2interactor31.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
54 TCERG1interactor40.6671.000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
55 THRAsuppressor100.6395.938C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
56 THRBsuppressor41.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
57 TP53suppressor220.32985.132DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
58 TRIM27oncoprotein50.5002.400IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
59 VAV2oncoprotein30.6671.000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
60 VDRsuppressor170.6509.829zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
61 ZC3H13interactor210.9431.363FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
62 ZNF655interactor21.0000Asr (PF06392, IPR009435): Acid shock protein repeat
Chordopox_RPO7 (PF05864, IPR008448): Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)
zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
63 ZSCAN1interactor40.6670.667SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

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