Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPN1, MECOM (from a repository: Thu Nov 10 14:59:26 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)169
The number (and %) of the onco-proteins49 (28.99 %)
The number (and %) of the tumor suppressors13 (7.69 %)
Total number of binary PPIs (saturation %)1727 (12.17 %)
The number (and %) of affected PPIs168 (9.73 %)
The number of possible different fusions30
PPI diameter4
PPI radius2
The average degree of PPI19.775
Assortativity coefficient-0.0826
The network average Clustering coefficient0.422
The number (and %) of a zero Clustering coefficients4 (2.37 %)
The number (and %) of a zero Betweenness Centrality9 (5.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MECOM,RPN1 All fusions
: AF310158;
Proteins found in more fusions TUBG1 (see 1 fusions); PSMC2 (see 1 fusions); CTBP1 (see 2 fusions); SMAD4 (see 2 fusions); STAU1 (see 2 fusions); PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); UBQLN1 (see 2 fusions); KAT2B (see 1 fusions); NELFB (see 1 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); OS9 (see 2 fusions); ILK (see 1 fusions); ATP1A1/VDAC3 (see 2 fusions); CRY2 (see 3 fusions); VCP (see 4 fusions); HDAC4 (see 1 fusions); ERBB3 (see 2 fusions); CREBBP (see 5 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); ATP5A1 (see 1 fusions); SUV39H1 (see 1 fusions); PSMC5 (see 2 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MECOMparental protein250.2271205.852SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
2 RPN1parental protein1430.1319434.428Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
3 ABCB7interactor40.5000.847ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
4 ACADMoncoprotein220.45963.354Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
5 ADRB2interactor240.37542.1297tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 AFG3L2interactor140.6159.452AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
7 ASB11interactor30.6670.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
8 ASB5interactor30.6670.200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
9 ATAD3Ainteractor200.34741.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
10 ATAD3Binteractor120.43920.173AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
11 ATF2oncoprotein220.305196.959bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
12 ATP1A1protein found in more fusions510.268457.133Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
13 ATP5A1protein found in more fusions360.309217.448ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
14 ATP5C1interactor350.392143.802ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
15 ATP5Linteractor160.38332.419ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
16 ATP6V0D1interactor180.51024.480vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
17 ATP6V1Ainteractor190.53835.102ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
18 BAG6interactor140.33358.397DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
19 BCAP29interactor40.6672.599Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
ZapB (PF06005, IPR009252): Cell division protein ZapB
20 BMI1oncoprotein170.34279.231zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
21 CANXinteractor450.288353.897Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
22 CCDC47interactor150.24845.152DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
23 CCT3interactor320.419104.780Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
24 CCT6Ainteractor360.400151.633Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
25 CCT7interactor240.55434.096Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
26 CCT8interactor300.43084.633Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
27 CDC5Linteractor360.328180.632OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
28 CDK9protein found in more fusions160.352157.850Pkinase (PF00069, IPR000719): Protein kinase domain
29 CLGNinteractor110.5279.588Calreticulin (PF00262, IPR001580): Calreticulin family
CDC45 (PF02724, IPR003874): CDC45-like protein
S-antigen (PF05756, IPR008825): S-antigen protein
DUF3742 (PF12553, IPR022213): Protein of unknown function (DUF3742)
SieB (PF14163, IPR025982): Super-infection exclusion protein B
30 CLN3interactor160.45025.932CLN3 (PF02487, IPR003492): CLN3 protein
31 CLN5interactor70.5243.721CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
32 CLTConcoprotein430.341221.654Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
33 COPS5protein found in more fusions330.361184.752JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
34 CREBBPsuppressor180.390112.897Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
35 CRY2protein found in more fusions130.30332.331DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
36 CTBP1protein found in more fusions180.265198.0312-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
37 CUL3protein found in more fusions540.266386.550Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
38 CYC1interactor260.37880.003Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
39 DDOSTinteractor390.340239.421DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
40 DDX39Ainteractor120.41835.335DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
41 DDX39Binteractor210.35287.900DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
42 ECT2suppressor110.20061.972BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
43 EEDsuppressor270.271346.874WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
44 EGFRoncoprotein370.243396.524Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
45 EHMT2interactor100.44424.071CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
46 EIF2S1interactor80.5362.865EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
47 EIF3Minteractor41.0000Death (PF00531, IPR000488, SM00005): Death domain
PCI (PF01399, IPR000717, SM00088): PCI domain
48 ELAVL1oncoprotein430.1871418.450RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
49 ERBB3oncoprotein100.38937.932Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
50 ESR1suppressor400.212568.746Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
51 EVC2interactor30.6670.333HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
52 FBXO25suppressor190.33936.054Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
53 FBXO6interactor560.212563.223FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
54 FN1oncoprotein420.202402.251fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
55 FOXJ2interactor30.6674.893SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
56 FOXRED2interactor70.5713.807Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
57 GSTK1interactor80.5713.435DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
58 HDAC1suppressor290.251417.713FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
59 HDAC4oncoprotein130.47047.538Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
60 HDAC5protein found in more fusions390.284370.968Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
61 HIC1suppressor90.46415.396BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
62 HNRNPUinteractor370.288345.125CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
63 HSD17B12interactor250.39768.638adh_short (PF00106, IPR002198): short chain dehydrogenase
64 HSP90B1suppressor360.351181.490CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
65 HSPA5oncoprotein400.270347.002HSP70 (PF00012, IPR013126): Hsp70 protein
66 IDH3Ainteractor160.38330.862Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
67 ILF3oncoprotein310.318159.332dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
68 ILKsuppressor210.44757.141Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
69 INSIG2interactor80.6074.109INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
70 IPO5interactor180.36664.958HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
71 IPO9interactor150.40031.541IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
72 KAT2Bprotein found in more fusions120.38242.565Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
73 KDSRoncoprotein100.60016.1297kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
74 LGR4interactor110.3785.7697tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
75 MBD3interactor70.40018.050DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
76 MCM2oncoprotein400.344140.706AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
77 MED23interactor110.382114.060Med23 (PF11573, IPR021629): Mediator complex subunit 23
78 MMS19interactor160.333134.207DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
79 MT-CO2interactor170.51519.864NA
80 MTCH1interactor150.35232.904YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
81 MTCH2interactor220.48145.911Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
82 MYConcoprotein330.266390.420HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
83 NDUFA12interactor90.6672.372NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
84 NDUFB8interactor130.55110.812NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
85 NDUFB9interactor90.6114.496Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
86 NELFBprotein found in more fusions80.6191.383COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
87 NHSinteractor30.6670.333Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
NHS (PF15273, IPR024845): NHS-like
88 NLRP14interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
89 NOMO1interactor70.4766.218DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
DUF2141 (PF09912, IPR018673): Uncharacterized protein conserved in bacteria (DUF2141)
NikM (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
SdrD_B (PF17210): SdrD B-like domain
90 NOMO2interactor21.0000DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
NikM (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
SdrD_B (PF17210): SdrD B-like domain
91 NTRK1oncoprotein800.1881508.072I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
92 OS9protein found in more fusions130.48541.540DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
93 OST4interactor21.0000Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
94 PCinteractor140.6265.758Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
95 PDIA6interactor150.45714.205FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
96 PIAS4interactor90.61118.161CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
97 PIK3R3interactor40.16733.641SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
98 PKMoncoprotein130.44910.771PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
99 PPIBinteractor160.31750.777Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
100 PPP2R1Aoncoprotein320.337221.561TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
101 PPP2R1Bsuppressor90.5009.035HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
102 PRMT1interactor130.379108.877Methyltransf_25 (PF13649): Methyltransferase domain
103 PRPF19protein found in more fusions160.41931.640Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
104 PSMC1interactor140.47350.555AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
105 PSMC2protein found in more fusions230.39064.969AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
106 PSMC3interactor190.32799.795AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
107 PSMC5protein found in more fusions250.315140.002AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
108 RAB1Aoncoprotein300.303184.934Ras (PF00071, IPR001806, SM00173): Ras family
109 RAB1Boncoprotein200.38452.604Ras (PF00071, IPR001806, SM00173): Ras family
110 RAB2Aoncoprotein200.27986.152Ras (PF00071, IPR001806, SM00173): Ras family
111 RAB5Aoncoprotein70.7625.476Ras (PF00071, IPR001806, SM00173): Ras family
112 RAB5Boncoprotein90.5569.412Ras (PF00071, IPR001806, SM00173): Ras family
113 RAB5Concoprotein150.43822.398Ras (PF00071, IPR001806, SM00173): Ras family
114 RABGAP1Loncoprotein100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3694 (PF12473, IPR022164): Kinesin protein
115 RDH13interactor70.6192.825adh_short (PF00106, IPR002198): short chain dehydrogenase
116 RNF185interactor130.30346.564zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
117 RNF2interactor310.218337.187zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
118 RPL35interactor80.7141.148Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
119 RPN2interactor380.279261.361Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
120 RPS6KB2interactor220.28697.912Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
121 RPSAinteractor220.46831.081Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
122 SCAMP2interactor30.6670.333SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
123 SCARNA22interactor60.7330.765NA
124 SCCPDHinteractor21.0000Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
125 SEL1Loncoprotein90.6116.304fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
126 SGTAinteractor50.7001.374TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
127 SIRT1suppressor130.33386.128DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
128 SLC25A3interactor430.309292.293Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
129 SLC25A5interactor250.303124.012Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
130 SLX4IPinteractor100UPF0492 (PF15744, IPR031479): Uncharacterized protein family UPF0492
131 SMAD1interactor90.7866.298MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
132 SMAD2suppressor210.326237.507MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
133 SMAD3oncoprotein200.345144.444MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
134 SMAD4suppressor130.47059.760MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
135 SND1interactor140.44050.310TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
136 SOX2oncoprotein130.197103.061HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
137 SPDEFinteractor100Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
138 SSR1interactor280.320161.799TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
139 SSR2interactor31.0000TRAP_beta (PF05753, IPR008856): Translocon-associated protein beta (TRAPB)
140 SSR3interactor160.42525.945TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
141 SSR4interactor280.35282.331TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
142 STAU1protein found in more fusions270.36371.874dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
143 STT3Binteractor120.39429.477STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
144 SUCLG2interactor100.48910.426ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
145 SUV39H1protein found in more fusions100.52834.906Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
146 SYNCRIPinteractor230.36496.421RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
147 TCP1interactor280.45081.710Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
148 TCTN1interactor110.4918.942DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
149 TCTN2interactor170.40435.443DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
150 TCTN3interactor200.33756.880DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
151 TECRinteractor280.43961.529Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
152 TMCO1interactor190.46841.618DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
153 TMEM63Binteractor90.6117.622RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
154 TMEM67interactor70.3817.744Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
155 TUBA1Cinteractor260.46251.483Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
156 TUBG1protein found in more fusions180.50047.958Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
157 TUFMinteractor250.31769.335GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
158 U2AF2protein found in more fusions330.385132.855RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
159 UBE2Iinteractor190.281189.572UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
160 UBL4Ainteractor270.276114.593ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
161 UBQLN1protein found in more fusions130.37918.403Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
162 UBQLN4interactor90.39327.849CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
163 UQCRC2oncoprotein510.278393.903Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
164 USP49interactor30.6670.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
165 VCAM1interactor290.25695.792C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
166 VCPprotein found in more fusions420.316377.530AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
167 VDAC1interactor280.42186.246Porin_3 (PF01459, IPR027246): Eukaryotic porin
168 VDAC2interactor400.318303.665Porin_3 (PF01459, IPR027246): Eukaryotic porin
169 VDAC3protein found in more fusions230.54234.410Porin_3 (PF01459, IPR027246): Eukaryotic porin

B a c k    t o    T o p ⇑