Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins MDH2 (from a repository: Sun Dec 4 07:08:41 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 49 The number (and %) of the onco-proteins 15 (30.61 %) The number (and %) of the tumor suppressors 7 (14.29 %) Total number of binary PPIs (saturation %) 235 (19.98 %) The number (and %) of affected PPIs 49 (20.85 %) The number of possible different fusions 11 PPI diameter 2 PPI radius 1 The average degree of PPI 8.735 Assortativity coefficient -0.1562 The network average Clustering coefficient 0.509 The number (and %) of a zero Clustering coefficients 3 (6.12 %) The number (and %) of a zero Betweenness Centrality 7 (14.29 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: MDH2	All fusions : BF794536;
Proteins found in more fusions	CUL7 (see 2 fusions); COPS5 (see 1 fusions); PPME1 (see 1 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); PCNA (see 1 fusions); MDH2 (see 1 fusions); ATP5A1 (see 1 fusions); ATP5A1/HUWE1 (see 2 fusions); U2AF2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	MDH2	parental protein	49	0.147	1250.243	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
2	ATF2	oncoprotein	8	0.333	7.291	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
3	ATP5A1	protein found in more fusions	15	0.451	21.773	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
4	ATP5B	interactor	18	0.340	63.197	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain NACHT (PF05729): NACHT domain
5	CCDC8	interactor	8	0.762	1.869	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
6	CDK2	suppressor	13	0.394	21.377	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
7	CFL1	interactor	17	0.309	67.440	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
8	CLNS1A	interactor	3	0.667	0.250	Voldacs (PF03517): Regulator of volume decrease after cellular swelling
9	COPS5	protein found in more fusions	9	0.464	7.636	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
10	CORO1C	oncoprotein	7	0.381	5.198	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat
11	COTL1	oncoprotein	2	1.000	0	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
12	CRYAB	oncoprotein	5	0.833	0.667	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
13	CUL7	protein found in more fusions	17	0.358	42.913	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14	DAZAP1	interactor	13	0.321	35.729	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
15	FH	suppressor	4	0.500	1.167	Lyase_1 (PF00206, IPR022761): Lyase FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
16	FN1	oncoprotein	14	0.308	38.941	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
17	FUS	suppressor	14	0.505	18.686	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
18	GLRX2	interactor	1	0	0	Glutaredoxin (PF00462, IPR002109): Glutaredoxin
19	GRPEL1	interactor	4	0.667	0.333	GrpE (PF01025, IPR000740): GrpE
20	GRSF1	interactor	3	0.667	0.667	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence VWA_N2 (PF16164, IPR032361): VWA N-terminal
21	HDAC5	protein found in more fusions	7	0.667	1.467	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
22	HUWE1	oncoprotein	15	0.330	41.352	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
23	IDH1	suppressor	5	0.500	2.900	Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
24	IDH3A	interactor	5	0.500	2.750	Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
25	ITGA4	interactor	13	0.439	21.156	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
26	LDHAL6A	interactor	3	1.000	0	Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27	METTL21B	interactor	2	1.000	0	Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
28	MRPS28	interactor	4	0.500	2.000	MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
29	NTRK1	oncoprotein	22	0.267	111.182	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
30	NUDC	interactor	9	0.333	14.677	CS (PF04969, IPR007052): CS domain D5_N (PF08706, IPR014818, SM00885): D5 N terminal like Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc. NuDC (PF16273, IPR032572): Nuclear distribution C domain
31	OBSL1	interactor	12	0.509	10.588	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
32	PARK2	suppressor	9	0.393	9.619	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33	PC	interactor	3	1.000	0	Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain HMGL-like (PF00682, IPR000891): HMGL-like PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
34	PCNA	oncoprotein	15	0.330	33.456	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
35	PPME1	protein found in more fusions	5	0.833	0.333	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
36	PSMA3	interactor	11	0.467	15.086	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
37	PSMD4	interactor	10	0.511	14.519	UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
38	QSOX2	interactor	1	0	0	Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family Thioredoxin (PF00085, IPR013766): Thioredoxin zf-HYPF (PF07503, IPR011125): HypF finger Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
39	RAB10	oncoprotein	6	0.667	2.008	Ras (PF00071, IPR001806, SM00173): Ras family
40	SDHA	suppressor	6	0.600	2.436	FAD_binding_2 (PF00890, IPR003953): FAD binding domain Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
41	SDHB	suppressor	5	0.700	1.200	Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain Fer4_17 (PF13534): 4Fe-4S dicluster domain
42	SERPINH1	interactor	9	0.528	6.910	Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
43	SOD1	interactor	10	0.389	17.400	Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
44	U2AF2	protein found in more fusions	10	0.528	7.808	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
45	UBE2L3	interactor	9	0.393	11.567	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46	UFM1	interactor	4	0.833	0.333	Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
47	VCAM1	interactor	9	0.528	6.977	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
48	WARS	interactor	5	0.800	0.900	tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
49	YKT6	interactor	1	0	0	Synaptobrevin (PF00957, IPR001388): Synaptobrevin Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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