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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins15 (30.61 %)
The number (and %) of the tumor suppressors7 (14.29 %)
Total number of binary PPIs (saturation %)235 (19.98 %)
The number (and %) of affected PPIs49 (20.85 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI8.735
Assortativity coefficient-0.1562
The network average Clustering coefficient0.509
The number (and %) of a zero Clustering coefficients3 (6.12 %)
The number (and %) of a zero Betweenness Centrality7 (14.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MDH2 All fusions
: BF794536;
Proteins found in more fusions CUL7 (see 2 fusions); COPS5 (see 1 fusions); PPME1 (see 1 fusions); HUWE1 (see 2 fusions); HDAC5 (see 1 fusions); PCNA (see 1 fusions); MDH2 (see 1 fusions); ATP5A1 (see 1 fusions); ATP5A1/HUWE1 (see 2 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MDH2parental protein490.1471250.243Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
2 ATF2oncoprotein80.3337.291bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
3 ATP5A1protein found in more fusions150.45121.773ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
4 ATP5Binteractor180.34063.197AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
5 CCDC8interactor80.7621.869Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
6 CDK2suppressor130.39421.377Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
7 CFL1interactor170.30967.440Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
8 CLNS1Ainteractor30.6670.250Voldacs (PF03517): Regulator of volume decrease after cellular swelling
9 COPS5protein found in more fusions90.4647.636JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
10 CORO1Concoprotein70.3815.198DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
11 COTL1oncoprotein21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
12 CRYABoncoprotein50.8330.667Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
13 CUL7protein found in more fusions170.35842.913ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
14 DAZAP1interactor130.32135.729RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
15 FHsuppressor40.5001.167Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
16 FN1oncoprotein140.30838.941fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
17 FUSsuppressor140.50518.686Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 GLRX2interactor100Glutaredoxin (PF00462, IPR002109): Glutaredoxin
19 GRPEL1interactor40.6670.333GrpE (PF01025, IPR000740): GrpE
20 GRSF1interactor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
21 HDAC5protein found in more fusions70.6671.467Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
22 HUWE1oncoprotein150.33041.352BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
23 IDH1suppressor50.5002.900Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
24 IDH3Ainteractor50.5002.750Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
25 ITGA4interactor130.43921.156FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
26 LDHAL6Ainteractor31.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
27 METTL21Binteractor21.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
28 MRPS28interactor40.5002.000MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
29 NTRK1oncoprotein220.267111.182I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
30 NUDCinteractor90.33314.677CS (PF04969, IPR007052): CS domain
D5_N (PF08706, IPR014818, SM00885): D5 N terminal like
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
NuDC (PF16273, IPR032572): Nuclear distribution C domain
31 OBSL1interactor120.50910.588BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
32 PARK2suppressor90.3939.619IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 PCinteractor31.0000Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
34 PCNAoncoprotein150.33033.456PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
35 PPME1protein found in more fusions50.8330.333Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
36 PSMA3interactor110.46715.086Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
37 PSMD4interactor100.51114.519UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
38 QSOX2interactor100Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
Evr1_Alr (PF04777, IPR017905): Erv1 / Alr family
Thioredoxin (PF00085, IPR013766): Thioredoxin
zf-HYPF (PF07503, IPR011125): HypF finger
Thioredoxin_2 (PF13098, IPR012336): Thioredoxin-like domain
39 RAB10oncoprotein60.6672.008Ras (PF00071, IPR001806, SM00173): Ras family
40 SDHAsuppressor60.6002.436FAD_binding_2 (PF00890, IPR003953): FAD binding domain
Succ_DH_flav_C (PF02910, IPR015939): Fumarate reductase flavoprotein C-term
41 SDHBsuppressor50.7001.200Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
42 SERPINH1interactor90.5286.910Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
43 SOD1interactor100.38917.400Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
44 U2AF2protein found in more fusions100.5287.808RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
45 UBE2L3interactor90.39311.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 UFM1interactor40.8330.333Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
47 VCAM1interactor90.5286.977C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
48 WARSinteractor50.8000.900tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
49 YKT6interactor100Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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